Health-Related Quality of Life Among Patients Who Have Survived an Episode of Sepsis in the United States: A Systematic Review
Abstract Introduction Sepsis is a serious condition that may lead to death or profoundly affect the well-being of those who survive. The aim of this systematic review was to identify and summarize evidence on the impact of all-cause sepsis on health-related quality of life (HRQoL), physical, cogniti...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2025-01-01
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| Series: | Infectious Diseases and Therapy |
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| Online Access: | https://doi.org/10.1007/s40121-024-01106-x |
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| author | Sanjukta Basu Ziyan J. Wei Atara Laor Liga Bennetts Nina Ahmad Antoine C. El Khoury Jeroen Geurtsen Maureen P. Neary |
| author_facet | Sanjukta Basu Ziyan J. Wei Atara Laor Liga Bennetts Nina Ahmad Antoine C. El Khoury Jeroen Geurtsen Maureen P. Neary |
| author_sort | Sanjukta Basu |
| collection | DOAJ |
| description | Abstract Introduction Sepsis is a serious condition that may lead to death or profoundly affect the well-being of those who survive. The aim of this systematic review was to identify and summarize evidence on the impact of all-cause sepsis on health-related quality of life (HRQoL), physical, cognitive, and psychological outcomes among sepsis survivors in the USA. Methods Studies assessing HRQoL, physical, cognitive, and psychological outcomes in patients who survived an episode of sepsis and published from January 1, 2010, to September 30, 2023, were systematically identified through EMBASE, MEDLINE, and MEDLINE In-Process databases, as well as through gray literature. Results Of 2885 records identified, 7 studies (7 publications; N = 180,592 participants) met the eligibility criteria for inclusion in this review. Studies examined the effects of sepsis on the following outcomes of interest: HRQoL (4 studies), physical functioning (5 studies), cognitive status (3 studies), and psychological well-being (3 studies). After 12 months, sepsis survivors who developed chronic critical illness (N = 63) had significantly poorer HRQoL as measured by EuroQoL 5-dimensional (EQ-5D) questionnaire mean utility index score and Short Form 36-item (SF-36) physical and mental summary scores compared with patients who rapidly recovered (N = 110). Among patients admitted to a skilled nursing facility post-sepsis (N = 66,540), 34% and 72.5% had severe or very severe cognitive impairment and dependence to perform activities of daily living, respectively. Significant increase in moderate-to-severe cognitive impairment among severe sepsis survivors (N = 623) before and after sepsis was reported (median 0.9 [IQR: 0.4, 1.4] years; 6.1% and 16.7%, respectively [P < 0.001]). Substantial depression and anxiety symptoms were frequently observed post-sepsis, but with limited evidence for increased burden as assessed by specific psychological measures. Conclusion These findings underscore the profound negative impacts of sepsis on patients’ HRQoL, ability to perform activities of daily living, and cognitive abilities. |
| format | Article |
| id | doaj-art-3f358a40e70f40e984b36272c04c9ba3 |
| institution | DOAJ |
| issn | 2193-8229 2193-6382 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Infectious Diseases and Therapy |
| spelling | doaj-art-3f358a40e70f40e984b36272c04c9ba32025-08-20T03:00:58ZengAdis, Springer HealthcareInfectious Diseases and Therapy2193-82292193-63822025-01-0114238540010.1007/s40121-024-01106-xHealth-Related Quality of Life Among Patients Who Have Survived an Episode of Sepsis in the United States: A Systematic ReviewSanjukta Basu0Ziyan J. Wei1Atara Laor2Liga Bennetts3Nina Ahmad4Antoine C. El Khoury5Jeroen Geurtsen6Maureen P. Neary7Amaris ConsultingAmaris ConsultingAmaris ConsultingAmaris ConsultingJanssen Global Services, LLCJanssen Global Services, LLCJanssen Vaccines and Prevention BVJanssen Global Services, LLCAbstract Introduction Sepsis is a serious condition that may lead to death or profoundly affect the well-being of those who survive. The aim of this systematic review was to identify and summarize evidence on the impact of all-cause sepsis on health-related quality of life (HRQoL), physical, cognitive, and psychological outcomes among sepsis survivors in the USA. Methods Studies assessing HRQoL, physical, cognitive, and psychological outcomes in patients who survived an episode of sepsis and published from January 1, 2010, to September 30, 2023, were systematically identified through EMBASE, MEDLINE, and MEDLINE In-Process databases, as well as through gray literature. Results Of 2885 records identified, 7 studies (7 publications; N = 180,592 participants) met the eligibility criteria for inclusion in this review. Studies examined the effects of sepsis on the following outcomes of interest: HRQoL (4 studies), physical functioning (5 studies), cognitive status (3 studies), and psychological well-being (3 studies). After 12 months, sepsis survivors who developed chronic critical illness (N = 63) had significantly poorer HRQoL as measured by EuroQoL 5-dimensional (EQ-5D) questionnaire mean utility index score and Short Form 36-item (SF-36) physical and mental summary scores compared with patients who rapidly recovered (N = 110). Among patients admitted to a skilled nursing facility post-sepsis (N = 66,540), 34% and 72.5% had severe or very severe cognitive impairment and dependence to perform activities of daily living, respectively. Significant increase in moderate-to-severe cognitive impairment among severe sepsis survivors (N = 623) before and after sepsis was reported (median 0.9 [IQR: 0.4, 1.4] years; 6.1% and 16.7%, respectively [P < 0.001]). Substantial depression and anxiety symptoms were frequently observed post-sepsis, but with limited evidence for increased burden as assessed by specific psychological measures. Conclusion These findings underscore the profound negative impacts of sepsis on patients’ HRQoL, ability to perform activities of daily living, and cognitive abilities.https://doi.org/10.1007/s40121-024-01106-xHealth-related quality of life (HRQoL)SepsisSystematic literature reviewUnited States |
| spellingShingle | Sanjukta Basu Ziyan J. Wei Atara Laor Liga Bennetts Nina Ahmad Antoine C. El Khoury Jeroen Geurtsen Maureen P. Neary Health-Related Quality of Life Among Patients Who Have Survived an Episode of Sepsis in the United States: A Systematic Review Infectious Diseases and Therapy Health-related quality of life (HRQoL) Sepsis Systematic literature review United States |
| title | Health-Related Quality of Life Among Patients Who Have Survived an Episode of Sepsis in the United States: A Systematic Review |
| title_full | Health-Related Quality of Life Among Patients Who Have Survived an Episode of Sepsis in the United States: A Systematic Review |
| title_fullStr | Health-Related Quality of Life Among Patients Who Have Survived an Episode of Sepsis in the United States: A Systematic Review |
| title_full_unstemmed | Health-Related Quality of Life Among Patients Who Have Survived an Episode of Sepsis in the United States: A Systematic Review |
| title_short | Health-Related Quality of Life Among Patients Who Have Survived an Episode of Sepsis in the United States: A Systematic Review |
| title_sort | health related quality of life among patients who have survived an episode of sepsis in the united states a systematic review |
| topic | Health-related quality of life (HRQoL) Sepsis Systematic literature review United States |
| url | https://doi.org/10.1007/s40121-024-01106-x |
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