Structure-Induced Dynamics of Erythrocyte Aggregates by Microscale Simulation
Erythrocyte aggregation and dissociation play an important role in the determination of hemodynamical properties of blood flow in microcirculation. This paper intends to investigate the adhesion and dissociation kinetics of erythrocytes through computational modeling. The technique of immersed bound...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Applied Mathematics |
| Online Access: | http://dx.doi.org/10.1155/2013/409387 |
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| author | Tong Wang Zhongwen Xing Dingyu Xing |
| author_facet | Tong Wang Zhongwen Xing Dingyu Xing |
| author_sort | Tong Wang |
| collection | DOAJ |
| description | Erythrocyte aggregation and dissociation play an important role in the determination of hemodynamical properties of blood flow in microcirculation. This paper intends to investigate the adhesion and dissociation kinetics of erythrocytes through computational
modeling. The technique of immersed boundary-fictitious domain method has been applied to the study of erythrocyte aggregates traversing modeled stenotic microchannels. The effects of stenosis geometry, cell membrane stiffness, and intercellular interaction strength on aggregate hemodynamics including transit velocity are studied. It is found that the width of the stenosis throat and shape of stenosis have a significant influence on the dissociation of the aggregates. Moreover, horizontally orientated erythrocyte aggregates are observed to dissociate much easier than their vertical counterparts under the same simulation conditions. Results from this study contribute to the fundamental understanding and knowledge on the biophysical characteristics of erythrocyte aggregates in microscopic blood flow, which will provide pathological insights into some human diseases, such as malaria. |
| format | Article |
| id | doaj-art-3f2cf87f53d04d7ea8f15a35716b072e |
| institution | Kabale University |
| issn | 1110-757X 1687-0042 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Applied Mathematics |
| spelling | doaj-art-3f2cf87f53d04d7ea8f15a35716b072e2025-02-03T01:12:13ZengWileyJournal of Applied Mathematics1110-757X1687-00422013-01-01201310.1155/2013/409387409387Structure-Induced Dynamics of Erythrocyte Aggregates by Microscale SimulationTong Wang0Zhongwen Xing1Dingyu Xing2Department of Mathematics, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, ChinaDepartment of Materials Science and Engineering, Nanjing University, Nanjing 210093, ChinaDepartment of Physics, Nanjing University, Nanjing 210093, ChinaErythrocyte aggregation and dissociation play an important role in the determination of hemodynamical properties of blood flow in microcirculation. This paper intends to investigate the adhesion and dissociation kinetics of erythrocytes through computational modeling. The technique of immersed boundary-fictitious domain method has been applied to the study of erythrocyte aggregates traversing modeled stenotic microchannels. The effects of stenosis geometry, cell membrane stiffness, and intercellular interaction strength on aggregate hemodynamics including transit velocity are studied. It is found that the width of the stenosis throat and shape of stenosis have a significant influence on the dissociation of the aggregates. Moreover, horizontally orientated erythrocyte aggregates are observed to dissociate much easier than their vertical counterparts under the same simulation conditions. Results from this study contribute to the fundamental understanding and knowledge on the biophysical characteristics of erythrocyte aggregates in microscopic blood flow, which will provide pathological insights into some human diseases, such as malaria.http://dx.doi.org/10.1155/2013/409387 |
| spellingShingle | Tong Wang Zhongwen Xing Dingyu Xing Structure-Induced Dynamics of Erythrocyte Aggregates by Microscale Simulation Journal of Applied Mathematics |
| title | Structure-Induced Dynamics of Erythrocyte Aggregates by Microscale Simulation |
| title_full | Structure-Induced Dynamics of Erythrocyte Aggregates by Microscale Simulation |
| title_fullStr | Structure-Induced Dynamics of Erythrocyte Aggregates by Microscale Simulation |
| title_full_unstemmed | Structure-Induced Dynamics of Erythrocyte Aggregates by Microscale Simulation |
| title_short | Structure-Induced Dynamics of Erythrocyte Aggregates by Microscale Simulation |
| title_sort | structure induced dynamics of erythrocyte aggregates by microscale simulation |
| url | http://dx.doi.org/10.1155/2013/409387 |
| work_keys_str_mv | AT tongwang structureinduceddynamicsoferythrocyteaggregatesbymicroscalesimulation AT zhongwenxing structureinduceddynamicsoferythrocyteaggregatesbymicroscalesimulation AT dingyuxing structureinduceddynamicsoferythrocyteaggregatesbymicroscalesimulation |