Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205
The filamentous bacteriophage fd, codisplaying antigenic determinants and a single chain antibody fragment directed against the dendritic cell receptor DEC-205, is a promising vaccine candidate for its safety and its ability to elicit innate and adaptive immune response in absence of adjuvants. By u...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/585078 |
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| _version_ | 1832557088118669312 |
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| author | Luciana D’Apice Valerio Costa Rossella Sartorius Maria Trovato Marianna Aprile Piergiuseppe De Berardinis |
| author_facet | Luciana D’Apice Valerio Costa Rossella Sartorius Maria Trovato Marianna Aprile Piergiuseppe De Berardinis |
| author_sort | Luciana D’Apice |
| collection | DOAJ |
| description | The filamentous bacteriophage fd, codisplaying antigenic determinants and a single chain antibody fragment directed against the dendritic cell receptor DEC-205, is a promising vaccine candidate for its safety and its ability to elicit innate and adaptive immune response in absence of adjuvants. By using a system vaccinology approach based on RNA-Sequencing (RNA-Seq) analysis, we describe a relevant gene modulation in dendritic cells pulsed with anti-DEC-205 bacteriophages fd. RNA-Seq data analysis indicates that the bacteriophage fd virions are sensed as a pathogen by dendritic cells; they activate the danger receptors that trigger an innate immune response and thus confer a strong adjuvanticity that is needed to obtain a long-lasting adaptive immune response. |
| format | Article |
| id | doaj-art-3f288813b6de4957a73e8a8f04ca5c9b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-3f288813b6de4957a73e8a8f04ca5c9b2025-02-03T05:43:38ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/585078585078Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205Luciana D’Apice0Valerio Costa1Rossella Sartorius2Maria Trovato3Marianna Aprile4Piergiuseppe De Berardinis5Institute of Protein Biochemistry (IBP), National Council of Research, 80131 Naples, ItalyInstitute of Genetics and Biophysics “A. Buzzati-Traverso” (IGB), National Council of Research, 80131 Naples, ItalyInstitute of Protein Biochemistry (IBP), National Council of Research, 80131 Naples, ItalyInstitute of Protein Biochemistry (IBP), National Council of Research, 80131 Naples, ItalyInstitute of Genetics and Biophysics “A. Buzzati-Traverso” (IGB), National Council of Research, 80131 Naples, ItalyInstitute of Protein Biochemistry (IBP), National Council of Research, 80131 Naples, ItalyThe filamentous bacteriophage fd, codisplaying antigenic determinants and a single chain antibody fragment directed against the dendritic cell receptor DEC-205, is a promising vaccine candidate for its safety and its ability to elicit innate and adaptive immune response in absence of adjuvants. By using a system vaccinology approach based on RNA-Sequencing (RNA-Seq) analysis, we describe a relevant gene modulation in dendritic cells pulsed with anti-DEC-205 bacteriophages fd. RNA-Seq data analysis indicates that the bacteriophage fd virions are sensed as a pathogen by dendritic cells; they activate the danger receptors that trigger an innate immune response and thus confer a strong adjuvanticity that is needed to obtain a long-lasting adaptive immune response.http://dx.doi.org/10.1155/2015/585078 |
| spellingShingle | Luciana D’Apice Valerio Costa Rossella Sartorius Maria Trovato Marianna Aprile Piergiuseppe De Berardinis Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205 Journal of Immunology Research |
| title | Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205 |
| title_full | Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205 |
| title_fullStr | Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205 |
| title_full_unstemmed | Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205 |
| title_short | Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205 |
| title_sort | stimulation of innate and adaptive immunity by using filamentous bacteriophage fd targeted to dec 205 |
| url | http://dx.doi.org/10.1155/2015/585078 |
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