The role of HIV-1 Gag and genomic RNA interactions in virion assembly

The role of HIV-1 Gag and genomic RNA interactions in virion assembly

The virion assembly represents a critical aspect of producing infectious progenies required for HIV-1 replication. Each step in that process, such as Gag-membrane binding, Gag-genomic RNA binding/packaging, Gag multimerization, and viral particle budding, has been extensively analyzed in a stepwise...

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Bibliographic Details
Main Authors: Takaaki Koma, Bao Quoc Le, Khanh Quoc Tran, Naoya Doi, Tomoyuki Kondo, Kei Miyakawa, Akio Adachi, Masako Nomaguchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Microbiology
Subjects:
HIV-1
virion assembly
Gag
RNA
membrane
Gag oligomerization
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1642090/full
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Summary:The virion assembly represents a critical aspect of producing infectious progenies required for HIV-1 replication. Each step in that process, such as Gag-membrane binding, Gag-genomic RNA binding/packaging, Gag multimerization, and viral particle budding, has been extensively analyzed in a stepwise and specific manner. While Gag proteins are the primary drivers of HIV-1 virion assembly, the interactions between Gag and RNA play a significant role in regulating the process. This article provides an updated overview and perspective on HIV-1 virion assembly, with a particular focus on the role of Gag-RNA interactions.
ISSN:1664-302X

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