The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia
Background/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumor necrosis factor-alpha (TNF-𝛼) and interleukin-6 (IL-6) are among the sensitive markers of systemic inflammation. The aim of this study was to evaluate the plasma levels of the cytokines; TNF-𝛼 and IL-...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/106145 |
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| Summary: | Background/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumor necrosis
factor-alpha (TNF-𝛼) and interleukin-6 (IL-6) are among the sensitive
markers of systemic inflammation. The aim of this study was to
evaluate the plasma levels of the cytokines; TNF-𝛼 and IL-6 in CAE patients. Methods. Plasma
concentrations of TNF-𝛼 and IL-6 were measured in 36 patients with CAE (28
males, mean age: 58.2±12 years), and results were compared with age and
sex-matched controls (n=32) without coronary artery ectasia. TNF-𝛼 and IL-6 concentrations in blood were assesed by
enzyme-linked immunosorbent assay (ELISA). Results.
Baseline characteristics of the two groups were similar.
TNF-𝛼 and IL-6 levels were significantly higher in CAE group
than controls (15.6±11.2 pg/mL versus 7.8±3.7 pg/mL, 𝑃<.001, and 17.2±12.6 versus 7.6±2.1 𝑃<.0001, resp.). Conclusion. CAE patients showed
increases in TNF-𝛼 and IL-6 levels compared to the controls. This study
provides evidence for alterations in the proinflamatory cytokines
which suggest the involvement of the immune system in the
pathophysiology of CAE. Further placebo-controlled studies are
needed to evaluate the clinical significance of this increase in
TNF-𝛼 and IL-6 levels. |
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| ISSN: | 0962-9351 1466-1861 |