Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy
ABSTRACT Aims Non‐compaction cardiomyopathy (NCM) is a congenital heart disease characterized by an arrest of the myocardial compaction process. Although NCM patients have impaired formation of microvasculature, the functional impact of these changes remains undefined. We sought to analyse a potenti...
Saved in:
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2020-06-01
|
Series: | ESC Heart Failure |
Subjects: | |
Online Access: | https://doi.org/10.1002/ehf2.12631 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
_version_ | 1832544395302273024 |
---|---|
author | Andraz Cerar Martina Jaklic Sabina Frljak Gregor Poglajen Gregor Zemljic Barbara Guzic Salobir Maja Dolenc Novak Monika Stalc Rok Zbacnik Mirta Kozelj |
author_facet | Andraz Cerar Martina Jaklic Sabina Frljak Gregor Poglajen Gregor Zemljic Barbara Guzic Salobir Maja Dolenc Novak Monika Stalc Rok Zbacnik Mirta Kozelj |
author_sort | Andraz Cerar |
collection | DOAJ |
description | ABSTRACT Aims Non‐compaction cardiomyopathy (NCM) is a congenital heart disease characterized by an arrest of the myocardial compaction process. Although NCM patients have impaired formation of microvasculature, the functional impact of these changes remains undefined. We sought to analyse a potential correlation between myocardial ischemia and heart failure severity in NCM patients. Methods and results We enrolled 41 NCM patients (28 male and 13 female), aged 21–70 years. In all patients, we have determined left ventricular end‐diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), and global longitudinal strain (GLS) by echocardiography. At the same time, serum levels of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) have been measured, and myocardial single‐photon emission computed tomography at rest and on stress was used to define significant myocardial ischemia defined as summed difference score ≥ 2. Myocardial ischemia has been demonstrated in 11 patients (27%, Group A), and 30 patients showed no significant ischemic changes (73%, Group B). The groups did not differ in sex, age, kidney, or liver function. When compared with Group B, Group A had significantly lower LVEF (35 ± 15% in Group A vs. 53 ± 11% in Group B, P < 0.001), higher LVEDV (188 ± 52 mL vs. 136 ± 52 mL, P = 0.007), lower GLS (−9.9 ± 5.2% vs. −14.5 ± 4.1%, P = 0.001), and higher NT‐proBNP levels (1691 ± 1883 pg/mL vs. 422 ± 877 pg/mL, P = 0.006). Overall, higher summed difference score was associated with lower LVEF (r = −0.48, P = 0.001), higher LVEDV (r = 0.39, P = 0.012), lower GLS (r = 0.352, P = 0.024), and higher levels of NT‐proBNP (r = 0.66, P < 0.001). Conclusions The presence of myocardial ischemia in patients with NCM is associated with worse left ventricular function, dilation of the left ventricle, and more pronounced neurohumoral activation. |
format | Article |
id | doaj-art-3f0eea0cc3bd4b788e0955c7f1dbb76e |
institution | Kabale University |
issn | 2055-5822 |
language | English |
publishDate | 2020-06-01 |
publisher | Wiley |
record_format | Article |
series | ESC Heart Failure |
spelling | doaj-art-3f0eea0cc3bd4b788e0955c7f1dbb76e2025-02-03T10:25:46ZengWileyESC Heart Failure2055-58222020-06-01731161116710.1002/ehf2.12631Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathyAndraz Cerar0Martina Jaklic1Sabina Frljak2Gregor Poglajen3Gregor Zemljic4Barbara Guzic Salobir5Maja Dolenc Novak6Monika Stalc7Rok Zbacnik8Mirta Kozelj9Advanced Heart Failure and Transplantation Programme, Department of Cardiology, University Medical Centre Ljubljana Zaloska 7 1525 Ljubljana SloveniaAdvanced Heart Failure and Transplantation Programme, Department of Cardiology, University Medical Centre Ljubljana Zaloska 7 1525 Ljubljana SloveniaAdvanced Heart Failure and Transplantation Programme, Department of Cardiology, University Medical Centre Ljubljana Zaloska 7 1525 Ljubljana SloveniaAdvanced Heart Failure and Transplantation Programme, Department of Cardiology, University Medical Centre Ljubljana Zaloska 7 1525 Ljubljana SloveniaAdvanced Heart Failure and Transplantation Programme, Department of Cardiology, University Medical Centre Ljubljana Zaloska 7 1525 Ljubljana SloveniaDepartment of Nuclear Medicine University Medical Centre Ljubljana Zaloska 7 1525 Ljubljana SloveniaDepartment of Nuclear Medicine University Medical Centre Ljubljana Zaloska 7 1525 Ljubljana SloveniaDepartment of Nuclear Medicine University Medical Centre Ljubljana Zaloska 7 1525 Ljubljana SloveniaDepartment of Radiology University Medical Centre Ljubljana Zaloska 7 1525 Ljubljana SloveniaFaculty of Medicine University of Ljubljana Vrazov trg 2 1000 Ljubljana SloveniaABSTRACT Aims Non‐compaction cardiomyopathy (NCM) is a congenital heart disease characterized by an arrest of the myocardial compaction process. Although NCM patients have impaired formation of microvasculature, the functional impact of these changes remains undefined. We sought to analyse a potential correlation between myocardial ischemia and heart failure severity in NCM patients. Methods and results We enrolled 41 NCM patients (28 male and 13 female), aged 21–70 years. In all patients, we have determined left ventricular end‐diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), and global longitudinal strain (GLS) by echocardiography. At the same time, serum levels of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) have been measured, and myocardial single‐photon emission computed tomography at rest and on stress was used to define significant myocardial ischemia defined as summed difference score ≥ 2. Myocardial ischemia has been demonstrated in 11 patients (27%, Group A), and 30 patients showed no significant ischemic changes (73%, Group B). The groups did not differ in sex, age, kidney, or liver function. When compared with Group B, Group A had significantly lower LVEF (35 ± 15% in Group A vs. 53 ± 11% in Group B, P < 0.001), higher LVEDV (188 ± 52 mL vs. 136 ± 52 mL, P = 0.007), lower GLS (−9.9 ± 5.2% vs. −14.5 ± 4.1%, P = 0.001), and higher NT‐proBNP levels (1691 ± 1883 pg/mL vs. 422 ± 877 pg/mL, P = 0.006). Overall, higher summed difference score was associated with lower LVEF (r = −0.48, P = 0.001), higher LVEDV (r = 0.39, P = 0.012), lower GLS (r = 0.352, P = 0.024), and higher levels of NT‐proBNP (r = 0.66, P < 0.001). Conclusions The presence of myocardial ischemia in patients with NCM is associated with worse left ventricular function, dilation of the left ventricle, and more pronounced neurohumoral activation.https://doi.org/10.1002/ehf2.12631Heart failure progressionMyocardial ischemiaNon‐compaction cardiomyopathy |
spellingShingle | Andraz Cerar Martina Jaklic Sabina Frljak Gregor Poglajen Gregor Zemljic Barbara Guzic Salobir Maja Dolenc Novak Monika Stalc Rok Zbacnik Mirta Kozelj Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy ESC Heart Failure Heart failure progression Myocardial ischemia Non‐compaction cardiomyopathy |
title | Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy |
title_full | Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy |
title_fullStr | Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy |
title_full_unstemmed | Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy |
title_short | Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy |
title_sort | impairment of myocardial perfusion correlates with heart failure severity in patients with non compaction cardiomyopathy |
topic | Heart failure progression Myocardial ischemia Non‐compaction cardiomyopathy |
url | https://doi.org/10.1002/ehf2.12631 |
work_keys_str_mv | AT andrazcerar impairmentofmyocardialperfusioncorrelateswithheartfailureseverityinpatientswithnoncompactioncardiomyopathy AT martinajaklic impairmentofmyocardialperfusioncorrelateswithheartfailureseverityinpatientswithnoncompactioncardiomyopathy AT sabinafrljak impairmentofmyocardialperfusioncorrelateswithheartfailureseverityinpatientswithnoncompactioncardiomyopathy AT gregorpoglajen impairmentofmyocardialperfusioncorrelateswithheartfailureseverityinpatientswithnoncompactioncardiomyopathy AT gregorzemljic impairmentofmyocardialperfusioncorrelateswithheartfailureseverityinpatientswithnoncompactioncardiomyopathy AT barbaraguzicsalobir impairmentofmyocardialperfusioncorrelateswithheartfailureseverityinpatientswithnoncompactioncardiomyopathy AT majadolencnovak impairmentofmyocardialperfusioncorrelateswithheartfailureseverityinpatientswithnoncompactioncardiomyopathy AT monikastalc impairmentofmyocardialperfusioncorrelateswithheartfailureseverityinpatientswithnoncompactioncardiomyopathy AT rokzbacnik impairmentofmyocardialperfusioncorrelateswithheartfailureseverityinpatientswithnoncompactioncardiomyopathy AT mirtakozelj impairmentofmyocardialperfusioncorrelateswithheartfailureseverityinpatientswithnoncompactioncardiomyopathy |