White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis

Abstract Multiple sclerosis (MS) is a prevalent neurological disorder marked by inflammation and demyelination, with fatigue being one of the most reported and debilitating symptoms. While fatigue occurs across various neurological conditions and even in healthy individuals, the specific mechanisms...

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Main Authors:	Alejandra Figueroa-Vargas, Sebastián Navarrete-Caro, Claudia Cárcamo, Ethel Ciampi, Macarena Vásquez-Torres, Bernardita Soler, Cristian Montalba, Matías Iriarte-Carter, María Paz Martínez-Molina, Patricio Carvajal-Paredes, Mariana Ayala-Ochoa, Víctor Márquez-Rodríguez, Paulo Figueroa-Taiba, Marcela Díaz-Díaz, Joaquín Herrero, Rodrigo Henríquez-Ch, Ximena Stecher, Carla Manterola, Francisco Zamorano, Pamela Guevara, Francisco Aboitiz, Pablo Billeke
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Series:	Scientific Reports
Subjects:	People with relapsing multiple sclerosis (PwRMS) Fatigue Inferior frontal gyrus (IFG) Frontal pole Magnetic resonance imaging (MRI) Diffusion tensor imaging (DTI)
Online Access:	https://doi.org/10.1038/s41598-025-01465-6
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White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis

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