Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategies
Primary sarcopenia is characterized by a progressive loss of skeletal muscle mass, strength, and physical function that occurs with aging. Despite the related adverse or even serious health outcomes, no medications are currently available for treating primary sarcopenia. Here, we discuss recent adva...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1526764/full |
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| author | Wei Yang Si-Cong Si Wei-Hua Wang Jing Li Yi-Xin Ma Huan Zhao Jia Liu |
| author_facet | Wei Yang Si-Cong Si Wei-Hua Wang Jing Li Yi-Xin Ma Huan Zhao Jia Liu |
| author_sort | Wei Yang |
| collection | DOAJ |
| description | Primary sarcopenia is characterized by a progressive loss of skeletal muscle mass, strength, and physical function that occurs with aging. Despite the related adverse or even serious health outcomes, no medications are currently available for treating primary sarcopenia. Here, we discuss recent advancements in understanding the mechanistic role of gut microbiota-muscle cross-talk in primary sarcopenia, and the therapeutic implications. The mechanistic insights encompass a causal role of gut dysbiosis in primary sarcopenia, potentially mediated through gut microbiota-derived bioactive metabolites, such as short-chain fatty acids (SCFAs), secondary bile acids, and their associated signaling pathways, which may be translated into the development of new microbiome-based treatment and diagnostic approaches. Furthermore, we identify challenges that need addressing in future studies to facilitate the translation into potential novel treatment and differential diagnosis for older individuals with sarcopenia. |
| format | Article |
| id | doaj-art-3f0aaee2b6aa483aa0c708b7a1a56a18 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-3f0aaee2b6aa483aa0c708b7a1a56a182025-01-28T06:41:01ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011610.3389/fmicb.2025.15267641526764Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategiesWei YangSi-Cong SiWei-Hua WangJing LiYi-Xin MaHuan ZhaoJia LiuPrimary sarcopenia is characterized by a progressive loss of skeletal muscle mass, strength, and physical function that occurs with aging. Despite the related adverse or even serious health outcomes, no medications are currently available for treating primary sarcopenia. Here, we discuss recent advancements in understanding the mechanistic role of gut microbiota-muscle cross-talk in primary sarcopenia, and the therapeutic implications. The mechanistic insights encompass a causal role of gut dysbiosis in primary sarcopenia, potentially mediated through gut microbiota-derived bioactive metabolites, such as short-chain fatty acids (SCFAs), secondary bile acids, and their associated signaling pathways, which may be translated into the development of new microbiome-based treatment and diagnostic approaches. Furthermore, we identify challenges that need addressing in future studies to facilitate the translation into potential novel treatment and differential diagnosis for older individuals with sarcopenia.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1526764/fullsarcopeniaprimary sarcopeniamuscle massgut microbiotaprobioticshort-chain fatty acids |
| spellingShingle | Wei Yang Si-Cong Si Wei-Hua Wang Jing Li Yi-Xin Ma Huan Zhao Jia Liu Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategies Frontiers in Microbiology sarcopenia primary sarcopenia muscle mass gut microbiota probiotic short-chain fatty acids |
| title | Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategies |
| title_full | Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategies |
| title_fullStr | Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategies |
| title_full_unstemmed | Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategies |
| title_short | Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategies |
| title_sort | gut dysbiosis in primary sarcopenia potential mechanisms and implications for novel microbiome based therapeutic strategies |
| topic | sarcopenia primary sarcopenia muscle mass gut microbiota probiotic short-chain fatty acids |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1526764/full |
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