Successful Treatment With Intravenous Lipid Emulsion of Accidental Amantadine Overdose: A Case Report
ABSTRACT A 2.5‐year‐old, 4.9 kg, Chinese Crested was accidentally administered a dose of 43.5 mg/kg of amantadine, resulting in the rapid onset of tremors, agitation, vertical nystagmus, and lack of pupillary light reflex in one eye. After unsuccessful treatment with methocarbamol, a 1.5 mL/kg bolus...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-05-01
|
| Series: | Veterinary Medicine and Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/vms3.70402 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850256034175647744 |
|---|---|
| author | Brett Hogberg Kristen Marshall Mark Vardanega |
| author_facet | Brett Hogberg Kristen Marshall Mark Vardanega |
| author_sort | Brett Hogberg |
| collection | DOAJ |
| description | ABSTRACT A 2.5‐year‐old, 4.9 kg, Chinese Crested was accidentally administered a dose of 43.5 mg/kg of amantadine, resulting in the rapid onset of tremors, agitation, vertical nystagmus, and lack of pupillary light reflex in one eye. After unsuccessful treatment with methocarbamol, a 1.5 mL/kg bolus of 20% intravenous lipid emulsion therapy was initiated followed by a 0.25 mL/kg/min continuous rate infusion. All clinical signs secondary to the amantadine toxicity resolved following intravenous lipid emulsion therapy and remained normal on 24 h, day 5, day 18, and day 50. This represents the first report of amantadine toxicity in a clinical setting and is the first case showing that intravenous lipid emulsion therapy could be an effective treatment for amantadine toxicity. |
| format | Article |
| id | doaj-art-3efeaadf60e945b087b9d1ea0719a80f |
| institution | OA Journals |
| issn | 2053-1095 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine and Science |
| spelling | doaj-art-3efeaadf60e945b087b9d1ea0719a80f2025-08-20T01:56:45ZengWileyVeterinary Medicine and Science2053-10952025-05-01113n/an/a10.1002/vms3.70402Successful Treatment With Intravenous Lipid Emulsion of Accidental Amantadine Overdose: A Case ReportBrett Hogberg0Kristen Marshall1Mark Vardanega2Ocean State Veterinary Specialist East Greenwich Rhode Island USAUniversity of Tennessee College of Veterinary Medicine Knoxville Tennessee USAOcean State Veterinary Specialist East Greenwich Rhode Island USAABSTRACT A 2.5‐year‐old, 4.9 kg, Chinese Crested was accidentally administered a dose of 43.5 mg/kg of amantadine, resulting in the rapid onset of tremors, agitation, vertical nystagmus, and lack of pupillary light reflex in one eye. After unsuccessful treatment with methocarbamol, a 1.5 mL/kg bolus of 20% intravenous lipid emulsion therapy was initiated followed by a 0.25 mL/kg/min continuous rate infusion. All clinical signs secondary to the amantadine toxicity resolved following intravenous lipid emulsion therapy and remained normal on 24 h, day 5, day 18, and day 50. This represents the first report of amantadine toxicity in a clinical setting and is the first case showing that intravenous lipid emulsion therapy could be an effective treatment for amantadine toxicity.https://doi.org/10.1002/vms3.70402amantadinecanineintoxicationintravenous lipid emulsion therapytremors |
| spellingShingle | Brett Hogberg Kristen Marshall Mark Vardanega Successful Treatment With Intravenous Lipid Emulsion of Accidental Amantadine Overdose: A Case Report Veterinary Medicine and Science amantadine canine intoxication intravenous lipid emulsion therapy tremors |
| title | Successful Treatment With Intravenous Lipid Emulsion of Accidental Amantadine Overdose: A Case Report |
| title_full | Successful Treatment With Intravenous Lipid Emulsion of Accidental Amantadine Overdose: A Case Report |
| title_fullStr | Successful Treatment With Intravenous Lipid Emulsion of Accidental Amantadine Overdose: A Case Report |
| title_full_unstemmed | Successful Treatment With Intravenous Lipid Emulsion of Accidental Amantadine Overdose: A Case Report |
| title_short | Successful Treatment With Intravenous Lipid Emulsion of Accidental Amantadine Overdose: A Case Report |
| title_sort | successful treatment with intravenous lipid emulsion of accidental amantadine overdose a case report |
| topic | amantadine canine intoxication intravenous lipid emulsion therapy tremors |
| url | https://doi.org/10.1002/vms3.70402 |
| work_keys_str_mv | AT bretthogberg successfultreatmentwithintravenouslipidemulsionofaccidentalamantadineoverdoseacasereport AT kristenmarshall successfultreatmentwithintravenouslipidemulsionofaccidentalamantadineoverdoseacasereport AT markvardanega successfultreatmentwithintravenouslipidemulsionofaccidentalamantadineoverdoseacasereport |