Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes
Objective. To compare the serum concentration of IL-6, IL-10, TNF, IL-8, resistin, and adiponectin in type 1 diabetic patients with and without metabolic syndrome and to determine the cut-off point of the estimated glucose disposal rate that accurately differentiated these groups. Design. We conduct...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/972073 |
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| author | Aldo Ferreira-Hermosillo Mario Molina-Ayala Claudia Ramírez-Rentería Guadalupe Vargas Baldomero Gonzalez Armando Isibasi Irma Archundia-Riveros Victoria Mendoza |
| author_facet | Aldo Ferreira-Hermosillo Mario Molina-Ayala Claudia Ramírez-Rentería Guadalupe Vargas Baldomero Gonzalez Armando Isibasi Irma Archundia-Riveros Victoria Mendoza |
| author_sort | Aldo Ferreira-Hermosillo |
| collection | DOAJ |
| description | Objective. To compare the serum concentration of IL-6, IL-10, TNF, IL-8, resistin, and adiponectin in type 1 diabetic patients with and without metabolic syndrome and to determine the cut-off point of the estimated glucose disposal rate that accurately differentiated these groups. Design. We conducted a cross-sectional evaluation of all patients in our type 1 diabetes clinic from January 2012 to January 2013. Patients were considered to have metabolic syndrome when they fulfilled the joint statement criteria and were evaluated for clinical, biochemical, and immunological features. Methods. We determined serum IL-6, IL-8, IL-10, and TNF with flow cytometry and adiponectin and resistin concentrations with enzyme linked immunosorbent assay in patients with and without metabolic syndrome. We also compared estimated glucose disposal rate between groups. Results. We tested 140 patients. Forty-four percent fulfilled the metabolic syndrome criteria (n=61), 54% had central obesity, 30% had hypertriglyceridemia, 29% had hypoalphalipoproteinemia, and 19% had hypertension. We observed that resistin concentrations were higher in patients with MS. Conclusion. We found a high prevalence of MS in Mexican patients with T1D. The increased level of resistin may be related to the increased fat mass and could be involved in the development of insulin resistance. |
| format | Article |
| id | doaj-art-3efe229403e9472588e4d766bd9f2040 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-3efe229403e9472588e4d766bd9f20402025-02-03T01:32:08ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/972073972073Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 DiabetesAldo Ferreira-Hermosillo0Mario Molina-Ayala1Claudia Ramírez-Rentería2Guadalupe Vargas3Baldomero Gonzalez4Armando Isibasi5Irma Archundia-Riveros6Victoria Mendoza7Endocrinology Department, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Cuauhtémoc 330, Colonia Doctores, 06720 Mexico City, MEX, MexicoEndocrinology Department, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Cuauhtémoc 330, Colonia Doctores, 06720 Mexico City, MEX, MexicoExperimental Endocrinology Investigation Unit, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Cuauhtémoc 330, Colonia Doctores, 06720 Mexico City, MEX, MexicoEndocrinology Department, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Cuauhtémoc 330, Colonia Doctores, 06720 Mexico City, MEX, MexicoEndocrinology Department, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Cuauhtémoc 330, Colonia Doctores, 06720 Mexico City, MEX, MexicoImmunochemistry Medical Investigation Unit, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Cuauhtémoc 330, Colonia Doctores, 06720 Mexico City, MEX, MexicoImmunochemistry Medical Investigation Unit, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Cuauhtémoc 330, Colonia Doctores, 06720 Mexico City, MEX, MexicoEndocrinology Department, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Cuauhtémoc 330, Colonia Doctores, 06720 Mexico City, MEX, MexicoObjective. To compare the serum concentration of IL-6, IL-10, TNF, IL-8, resistin, and adiponectin in type 1 diabetic patients with and without metabolic syndrome and to determine the cut-off point of the estimated glucose disposal rate that accurately differentiated these groups. Design. We conducted a cross-sectional evaluation of all patients in our type 1 diabetes clinic from January 2012 to January 2013. Patients were considered to have metabolic syndrome when they fulfilled the joint statement criteria and were evaluated for clinical, biochemical, and immunological features. Methods. We determined serum IL-6, IL-8, IL-10, and TNF with flow cytometry and adiponectin and resistin concentrations with enzyme linked immunosorbent assay in patients with and without metabolic syndrome. We also compared estimated glucose disposal rate between groups. Results. We tested 140 patients. Forty-four percent fulfilled the metabolic syndrome criteria (n=61), 54% had central obesity, 30% had hypertriglyceridemia, 29% had hypoalphalipoproteinemia, and 19% had hypertension. We observed that resistin concentrations were higher in patients with MS. Conclusion. We found a high prevalence of MS in Mexican patients with T1D. The increased level of resistin may be related to the increased fat mass and could be involved in the development of insulin resistance.http://dx.doi.org/10.1155/2015/972073 |
| spellingShingle | Aldo Ferreira-Hermosillo Mario Molina-Ayala Claudia Ramírez-Rentería Guadalupe Vargas Baldomero Gonzalez Armando Isibasi Irma Archundia-Riveros Victoria Mendoza Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes Journal of Diabetes Research |
| title | Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes |
| title_full | Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes |
| title_fullStr | Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes |
| title_full_unstemmed | Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes |
| title_short | Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes |
| title_sort | inflammatory cytokine profile associated with metabolic syndrome in adult patients with type 1 diabetes |
| url | http://dx.doi.org/10.1155/2015/972073 |
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