Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil
In Brazil, malaria is prevalent in the Amazon region and these regions coincide with high prevalence of intestinal parasites but few studies explore the interaction between malaria and other parasites. Therefore, the present study evaluates changes in cytokine, chemokine, C-reactive protein, and nit...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/857245 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562727042678784 |
|---|---|
| author | Juan Camilo Sánchez-Arcila Daiana de Souza Perce-da-Silva Mariana Pinheiro Alves Vasconcelos Rodrigo Nunes Rodrigues-da-Silva Virginia Araujo Pereira Cesarino Junior Lima Aprígio Cleoni Alves Mendes Lima Bruna de Paula Fonseca e Fonseca Dalma Maria Banic Josué da Costa Lima-Junior Joseli Oliveira-Ferreira |
| author_facet | Juan Camilo Sánchez-Arcila Daiana de Souza Perce-da-Silva Mariana Pinheiro Alves Vasconcelos Rodrigo Nunes Rodrigues-da-Silva Virginia Araujo Pereira Cesarino Junior Lima Aprígio Cleoni Alves Mendes Lima Bruna de Paula Fonseca e Fonseca Dalma Maria Banic Josué da Costa Lima-Junior Joseli Oliveira-Ferreira |
| author_sort | Juan Camilo Sánchez-Arcila |
| collection | DOAJ |
| description | In Brazil, malaria is prevalent in the Amazon region and these regions coincide with high prevalence of intestinal parasites but few studies explore the interaction between malaria and other parasites. Therefore, the present study evaluates changes in cytokine, chemokine, C-reactive protein, and nitric oxide (NO) concentrations in 264 individuals, comparing plasma from infected individuals with concurrent malaria and intestinal parasites to individuals with either malaria infection alone and uninfected. In the studied population 24% of the individuals were infected with Plasmodium and 18% coinfected with intestinal parasites. Protozoan parasites comprised the bulk of the intestinal parasites infections and subjects infected with intestinal parasites were more likely to have malaria. The use of principal component analysis and cluster analysis associated increased levels of IL-6, TNF-α, IL-10, and CRP and low levels of IL-17A predominantly with individuals with malaria alone and coinfected individuals. In contrast, low levels of almost all inflammatory mediators were associated predominantly with individuals uninfected while increased levels of IL-17A were associated predominantly with individuals with intestinal parasites only. In conclusion, our data suggest that, in our population, the infection with intestinal parasites (mainly protozoan) does not modify the pattern of cytokine production in individuals infected with P. falciparum and P. vivax. |
| format | Article |
| id | doaj-art-3ef25f66b3bc46b887adc2371c12838d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3ef25f66b3bc46b887adc2371c12838d2025-02-03T01:21:58ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/857245857245Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of BrazilJuan Camilo Sánchez-Arcila0Daiana de Souza Perce-da-Silva1Mariana Pinheiro Alves Vasconcelos2Rodrigo Nunes Rodrigues-da-Silva3Virginia Araujo Pereira4Cesarino Junior Lima Aprígio5Cleoni Alves Mendes Lima6Bruna de Paula Fonseca e Fonseca7Dalma Maria Banic8Josué da Costa Lima-Junior9Joseli Oliveira-Ferreira10Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-900 Rio de Janeiro, RJ, BrazilLaboratório de Simulídeos e Oncocercose, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-900 Rio de Janeiro, RJ, BrazilInstituto de Infectologia Emílio Ribas, 01246-900 São Paulo, SP, BrazilLaboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-900 Rio de Janeiro, RJ, BrazilLaboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-900 Rio de Janeiro, RJ, BrazilAgencia de Vigilância em Saúde da Secretaria de Estado da Saúde (AGEVISA), 78900-000 Porto Velho, RO, BrazilCentro Interdepartamental de Biologia Experimental e Biotecnologia, Universidade Federal de Rondonia, 78900-000 Porto Velho, RO, BrazilLaboratório de Tecnologia Diagnóstica, Bio-Manguinhos, Fundação Oswaldo Cruz, 21040-900 Rio de Janeiro, RJ, BrazilLaboratório de Simulídeos e Oncocercose, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-900 Rio de Janeiro, RJ, BrazilLaboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-900 Rio de Janeiro, RJ, BrazilLaboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-900 Rio de Janeiro, RJ, BrazilIn Brazil, malaria is prevalent in the Amazon region and these regions coincide with high prevalence of intestinal parasites but few studies explore the interaction between malaria and other parasites. Therefore, the present study evaluates changes in cytokine, chemokine, C-reactive protein, and nitric oxide (NO) concentrations in 264 individuals, comparing plasma from infected individuals with concurrent malaria and intestinal parasites to individuals with either malaria infection alone and uninfected. In the studied population 24% of the individuals were infected with Plasmodium and 18% coinfected with intestinal parasites. Protozoan parasites comprised the bulk of the intestinal parasites infections and subjects infected with intestinal parasites were more likely to have malaria. The use of principal component analysis and cluster analysis associated increased levels of IL-6, TNF-α, IL-10, and CRP and low levels of IL-17A predominantly with individuals with malaria alone and coinfected individuals. In contrast, low levels of almost all inflammatory mediators were associated predominantly with individuals uninfected while increased levels of IL-17A were associated predominantly with individuals with intestinal parasites only. In conclusion, our data suggest that, in our population, the infection with intestinal parasites (mainly protozoan) does not modify the pattern of cytokine production in individuals infected with P. falciparum and P. vivax.http://dx.doi.org/10.1155/2014/857245 |
| spellingShingle | Juan Camilo Sánchez-Arcila Daiana de Souza Perce-da-Silva Mariana Pinheiro Alves Vasconcelos Rodrigo Nunes Rodrigues-da-Silva Virginia Araujo Pereira Cesarino Junior Lima Aprígio Cleoni Alves Mendes Lima Bruna de Paula Fonseca e Fonseca Dalma Maria Banic Josué da Costa Lima-Junior Joseli Oliveira-Ferreira Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil Mediators of Inflammation |
| title | Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil |
| title_full | Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil |
| title_fullStr | Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil |
| title_full_unstemmed | Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil |
| title_short | Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil |
| title_sort | intestinal parasites coinfection does not alter plasma cytokines profile elicited in acute malaria in subjects from endemic area of brazil |
| url | http://dx.doi.org/10.1155/2014/857245 |
| work_keys_str_mv | AT juancamilosanchezarcila intestinalparasitescoinfectiondoesnotalterplasmacytokinesprofileelicitedinacutemalariainsubjectsfromendemicareaofbrazil AT daianadesouzapercedasilva intestinalparasitescoinfectiondoesnotalterplasmacytokinesprofileelicitedinacutemalariainsubjectsfromendemicareaofbrazil AT marianapinheiroalvesvasconcelos intestinalparasitescoinfectiondoesnotalterplasmacytokinesprofileelicitedinacutemalariainsubjectsfromendemicareaofbrazil AT rodrigonunesrodriguesdasilva intestinalparasitescoinfectiondoesnotalterplasmacytokinesprofileelicitedinacutemalariainsubjectsfromendemicareaofbrazil AT virginiaaraujopereira intestinalparasitescoinfectiondoesnotalterplasmacytokinesprofileelicitedinacutemalariainsubjectsfromendemicareaofbrazil AT cesarinojuniorlimaaprigio intestinalparasitescoinfectiondoesnotalterplasmacytokinesprofileelicitedinacutemalariainsubjectsfromendemicareaofbrazil AT cleonialvesmendeslima intestinalparasitescoinfectiondoesnotalterplasmacytokinesprofileelicitedinacutemalariainsubjectsfromendemicareaofbrazil AT brunadepaulafonsecaefonseca intestinalparasitescoinfectiondoesnotalterplasmacytokinesprofileelicitedinacutemalariainsubjectsfromendemicareaofbrazil AT dalmamariabanic intestinalparasitescoinfectiondoesnotalterplasmacytokinesprofileelicitedinacutemalariainsubjectsfromendemicareaofbrazil AT josuedacostalimajunior intestinalparasitescoinfectiondoesnotalterplasmacytokinesprofileelicitedinacutemalariainsubjectsfromendemicareaofbrazil AT joselioliveiraferreira intestinalparasitescoinfectiondoesnotalterplasmacytokinesprofileelicitedinacutemalariainsubjectsfromendemicareaofbrazil |