Clinical and Imaging Features of Familial and Sporadic Multiple Sclerosis
Background: Multiple sclerosis (MS) is a demyelinating neurodegenerative disease affecting the central nervous system (CNS). While most cases are sporadic, familial MS (FMS) constitutes approximately 12.6% of the MS population and is characterized by affected family members. This study aims to inves...
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| Format: | Article |
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Guilan University of Medical Sciences
2025-01-01
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| Series: | Caspian Journal of Neurological Sciences |
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| Online Access: | http://cjns.gums.ac.ir/article-1-748-en.pdf |
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| author | Kamal AmirAshjei Asalemi Alia Saberi Amirreza Ghayeghran Sima Fallah Arzpeyma Sharareh Eskandarieh Mohammad Ali Sahraian Hamidreza Hatamian Kasra Sarlak Negin Ashoori Nima Broomand Lomer |
| author_facet | Kamal AmirAshjei Asalemi Alia Saberi Amirreza Ghayeghran Sima Fallah Arzpeyma Sharareh Eskandarieh Mohammad Ali Sahraian Hamidreza Hatamian Kasra Sarlak Negin Ashoori Nima Broomand Lomer |
| author_sort | Kamal AmirAshjei Asalemi |
| collection | DOAJ |
| description | Background: Multiple sclerosis (MS) is a demyelinating neurodegenerative disease affecting the central nervous system (CNS). While most cases are sporadic, familial MS (FMS) constitutes approximately 12.6% of the MS population and is characterized by affected family members. This study aims to investigate the difference between clinical and radiological findings of patients with FMS and sporadic MS (SMS) living in Guilan Province, Iran.
Materials & Methods: In this cross-sectional study, by evaluating their medical records, we examined 113 patients with SMS and 79 patients with FMS who registered in the nationwide MS registry of Iran (NMSRI)-Guilan. The radiologic data were analyzed using OsiriX software, version 12.0.
Results: Compared to the FMS group, the SMS group showed significantly higher age at onset (31.48±9.55 vs 28.92±9.46, P=0.034), higher occurrence of diplopia (29.2% vs 16.4%, P=0.042), higher expanded disability status scale (EDSS) score (2.20±2.61 vs 1.09±2.08, P=0.002), more lesions (31.59±25.36 vs 22.83±17.17, P=0.017), higher frequency of lesions in the periventricular region (98.2% vs 89.8%, P=0.017) and the lower average size of the smallest lesions (4.65±2.57 vs 8.12±8.58, P<0.001). EDSS score showed significant associations with type of MS (SMS or FMS) (β=0.78, P=0.016), onset age (β=0.09, P<0.001) and disease duration (β=0.13, P=0.001).
Conclusion: FMS differs from SMS with an earlier onset, predominantly relapsing-remitting phenotype, lower diplopia incidence, lower EDSS scores, fewer periventricular lesions and larger smallest lesions. |
| format | Article |
| id | doaj-art-3ee73c968f974966b0eb776ac199a126 |
| institution | Kabale University |
| issn | 2423-4818 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Neurological Sciences |
| spelling | doaj-art-3ee73c968f974966b0eb776ac199a1262025-02-04T11:29:02ZengGuilan University of Medical SciencesCaspian Journal of Neurological Sciences2423-48182025-01-011111727Clinical and Imaging Features of Familial and Sporadic Multiple SclerosisKamal AmirAshjei Asalemi0Alia Saberi1Amirreza Ghayeghran2Sima Fallah Arzpeyma3Sharareh Eskandarieh4Mohammad Ali Sahraian5Hamidreza Hatamian6Kasra Sarlak7Negin Ashoori8Nima Broomand Lomer9 Department of Neurology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Neurosciences Research Center, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Neurosciences Research Center, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Department of Radiology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran. Neuroscience Institute, Multiple Sclerosis Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Neuroscience Institute, Multiple Sclerosis Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Neurosciences Research Center, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Department of Neurology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Department of Neurology, Faculty of Medicine, Ardabil Branch, Islamic Azad University, Ardabil, Iran. Department of Neurology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Background: Multiple sclerosis (MS) is a demyelinating neurodegenerative disease affecting the central nervous system (CNS). While most cases are sporadic, familial MS (FMS) constitutes approximately 12.6% of the MS population and is characterized by affected family members. This study aims to investigate the difference between clinical and radiological findings of patients with FMS and sporadic MS (SMS) living in Guilan Province, Iran. Materials & Methods: In this cross-sectional study, by evaluating their medical records, we examined 113 patients with SMS and 79 patients with FMS who registered in the nationwide MS registry of Iran (NMSRI)-Guilan. The radiologic data were analyzed using OsiriX software, version 12.0. Results: Compared to the FMS group, the SMS group showed significantly higher age at onset (31.48±9.55 vs 28.92±9.46, P=0.034), higher occurrence of diplopia (29.2% vs 16.4%, P=0.042), higher expanded disability status scale (EDSS) score (2.20±2.61 vs 1.09±2.08, P=0.002), more lesions (31.59±25.36 vs 22.83±17.17, P=0.017), higher frequency of lesions in the periventricular region (98.2% vs 89.8%, P=0.017) and the lower average size of the smallest lesions (4.65±2.57 vs 8.12±8.58, P<0.001). EDSS score showed significant associations with type of MS (SMS or FMS) (β=0.78, P=0.016), onset age (β=0.09, P<0.001) and disease duration (β=0.13, P=0.001). Conclusion: FMS differs from SMS with an earlier onset, predominantly relapsing-remitting phenotype, lower diplopia incidence, lower EDSS scores, fewer periventricular lesions and larger smallest lesions.http://cjns.gums.ac.ir/article-1-748-en.pdfmultiple sclerosismagnetic resonance imagingrelapsing-remittingdisability evaluation |
| spellingShingle | Kamal AmirAshjei Asalemi Alia Saberi Amirreza Ghayeghran Sima Fallah Arzpeyma Sharareh Eskandarieh Mohammad Ali Sahraian Hamidreza Hatamian Kasra Sarlak Negin Ashoori Nima Broomand Lomer Clinical and Imaging Features of Familial and Sporadic Multiple Sclerosis Caspian Journal of Neurological Sciences multiple sclerosis magnetic resonance imaging relapsing-remitting disability evaluation |
| title | Clinical and Imaging Features of Familial and Sporadic Multiple Sclerosis |
| title_full | Clinical and Imaging Features of Familial and Sporadic Multiple Sclerosis |
| title_fullStr | Clinical and Imaging Features of Familial and Sporadic Multiple Sclerosis |
| title_full_unstemmed | Clinical and Imaging Features of Familial and Sporadic Multiple Sclerosis |
| title_short | Clinical and Imaging Features of Familial and Sporadic Multiple Sclerosis |
| title_sort | clinical and imaging features of familial and sporadic multiple sclerosis |
| topic | multiple sclerosis magnetic resonance imaging relapsing-remitting disability evaluation |
| url | http://cjns.gums.ac.ir/article-1-748-en.pdf |
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