Lack of association between the TMPRSS6 gene polymorphism (rs855791) and anemia: a comprehensive meta-analysis
Background: Anemia affects around 1.6 billion people worldwide and presents a significant challenge for healthcare providers. Despite the hemoglobin concentration being commonly used for diagnosis, identifying underlying causes remains challenging, particularly in vulnerable groups like children und...
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| Format: | Article |
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Elsevier
2025-04-01
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| Series: | Hematology, Transfusion and Cell Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137925000057 |
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| author | Jethendra Kumar Muruganantham Ramakrishnan Veerabathiran |
| author_facet | Jethendra Kumar Muruganantham Ramakrishnan Veerabathiran |
| author_sort | Jethendra Kumar Muruganantham |
| collection | DOAJ |
| description | Background: Anemia affects around 1.6 billion people worldwide and presents a significant challenge for healthcare providers. Despite the hemoglobin concentration being commonly used for diagnosis, identifying underlying causes remains challenging, particularly in vulnerable groups like children under five and pregnant women. Genetic factors, notably variations in the TMPRSS6 gene, are implicated in iron deficiency anemia, yet the precise relationship with anemia remains unclear. Methods: A thorough literature search was conducted across databases, including Embase, Google Scholar, and PubMed, focusing on studies investigating TMPRSS6 gene polymorphisms and anemia. Thirteen eligible studies, comprising 2082 cases and 2684 controls, underwent meta-analysis using Review Manager 5.4 software. Various genetic models were assessed, including allelic, homozygous, heterozygous, dominant, and recessive, with no significant relationship found between the TMPRSS6 rs855791 polymorphism and anemia. Conclusion: This meta-analysis provides robust evidence suggesting no significant association between the TMPRSS6 rs855791gene polymorphism and anemia. These findings underscore the complexity of genetic factors contributing to anemia and emphasize the importance of the further investigation to unravel the mechanisms underlying this relationship for improved diagnostic and therapeutic approaches. |
| format | Article |
| id | doaj-art-3ee378b9e9ad4a7e911d2f45df609a1b |
| institution | OA Journals |
| issn | 2531-1379 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj-art-3ee378b9e9ad4a7e911d2f45df609a1b2025-08-20T01:52:22ZengElsevierHematology, Transfusion and Cell Therapy2531-13792025-04-0147210373710.1016/j.htct.2025.103737Lack of association between the TMPRSS6 gene polymorphism (rs855791) and anemia: a comprehensive meta-analysisJethendra Kumar Muruganantham0Ramakrishnan Veerabathiran1Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamilnadu 603103, IndiaCorresponding author at: Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, 603103 Tamilnadu, India.; Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamilnadu 603103, IndiaBackground: Anemia affects around 1.6 billion people worldwide and presents a significant challenge for healthcare providers. Despite the hemoglobin concentration being commonly used for diagnosis, identifying underlying causes remains challenging, particularly in vulnerable groups like children under five and pregnant women. Genetic factors, notably variations in the TMPRSS6 gene, are implicated in iron deficiency anemia, yet the precise relationship with anemia remains unclear. Methods: A thorough literature search was conducted across databases, including Embase, Google Scholar, and PubMed, focusing on studies investigating TMPRSS6 gene polymorphisms and anemia. Thirteen eligible studies, comprising 2082 cases and 2684 controls, underwent meta-analysis using Review Manager 5.4 software. Various genetic models were assessed, including allelic, homozygous, heterozygous, dominant, and recessive, with no significant relationship found between the TMPRSS6 rs855791 polymorphism and anemia. Conclusion: This meta-analysis provides robust evidence suggesting no significant association between the TMPRSS6 rs855791gene polymorphism and anemia. These findings underscore the complexity of genetic factors contributing to anemia and emphasize the importance of the further investigation to unravel the mechanisms underlying this relationship for improved diagnostic and therapeutic approaches.http://www.sciencedirect.com/science/article/pii/S2531137925000057GeneticsAnemiaPolymorphismsTMPRSS6 geneIron deficiency |
| spellingShingle | Jethendra Kumar Muruganantham Ramakrishnan Veerabathiran Lack of association between the TMPRSS6 gene polymorphism (rs855791) and anemia: a comprehensive meta-analysis Hematology, Transfusion and Cell Therapy Genetics Anemia Polymorphisms TMPRSS6 gene Iron deficiency |
| title | Lack of association between the TMPRSS6 gene polymorphism (rs855791) and anemia: a comprehensive meta-analysis |
| title_full | Lack of association between the TMPRSS6 gene polymorphism (rs855791) and anemia: a comprehensive meta-analysis |
| title_fullStr | Lack of association between the TMPRSS6 gene polymorphism (rs855791) and anemia: a comprehensive meta-analysis |
| title_full_unstemmed | Lack of association between the TMPRSS6 gene polymorphism (rs855791) and anemia: a comprehensive meta-analysis |
| title_short | Lack of association between the TMPRSS6 gene polymorphism (rs855791) and anemia: a comprehensive meta-analysis |
| title_sort | lack of association between the tmprss6 gene polymorphism rs855791 and anemia a comprehensive meta analysis |
| topic | Genetics Anemia Polymorphisms TMPRSS6 gene Iron deficiency |
| url | http://www.sciencedirect.com/science/article/pii/S2531137925000057 |
| work_keys_str_mv | AT jethendrakumarmuruganantham lackofassociationbetweenthetmprss6genepolymorphismrs855791andanemiaacomprehensivemetaanalysis AT ramakrishnanveerabathiran lackofassociationbetweenthetmprss6genepolymorphismrs855791andanemiaacomprehensivemetaanalysis |