Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study
BackgroundThe Atherogenic Index of Plasma (AIP) was originally developed primarily as a marker for assessing atherosclerosis. Consequently, this study investigates the potential association between AIP and type 2 diabetic complications through a cross-sectional design.MethodsThe National Metabolic M...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1537303/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832542365479337984 |
|---|---|
| author | Yue-Yang Zhang Yue-Yang Zhang Yue-Yang Zhang Yue-Yang Zhang Yue-Yang Zhang Xiao-Yu Yang Xiao-Yu Yang Xiao-Yu Yang Xiao-Yu Yang Xiao-Yu Yang Qin Wan Qin Wan Qin Wan Qin Wan Qin Wan |
| author_facet | Yue-Yang Zhang Yue-Yang Zhang Yue-Yang Zhang Yue-Yang Zhang Yue-Yang Zhang Xiao-Yu Yang Xiao-Yu Yang Xiao-Yu Yang Xiao-Yu Yang Xiao-Yu Yang Qin Wan Qin Wan Qin Wan Qin Wan Qin Wan |
| author_sort | Yue-Yang Zhang |
| collection | DOAJ |
| description | BackgroundThe Atherogenic Index of Plasma (AIP) was originally developed primarily as a marker for assessing atherosclerosis. Consequently, this study investigates the potential association between AIP and type 2 diabetic complications through a cross-sectional design.MethodsThe National Metabolic Management Center(MMC) serves as a comprehensive platform dedicated to the establishment of standardized protocols for the diagnosis, treatment, and long-term follow-up of metabolic diseases. Following the relevant inclusion and exclusion criteria, a total of 3,094 patients were enrolled for subsequent analysis. In this study, logistic regression, restricted cubic splines, and subgroup analyses were employed to evaluate the association between the AIP and four major complications of type 2 diabetes, namely, type 2 diabetes with carotid atherosclerosis (DA), diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN).ResultsThe logistic regression results demonstrate that in the fully adjusted model, each SD increase in AIP correlates with an elevated risk of type 2 diabetic kidney disease (DKD), with the risk of kidney damage intensifying alongside higher AIP groupings. The RCS analysis and subgroup analyses similarly revealed a dose-response relationship between AIP levels and the risk of DKD. Furthermore, the AIP was not found to be statistically significantly associated with DA, DR,and DPN.ConclusionsThe AIP may serve as a valuable predictive indicator for evaluating kidney damage in patients with type 2 diabetes, and regular screening of AIP in this population could provide significant benefits in the prevention of DKD. |
| format | Article |
| id | doaj-art-3edc0df4baab4064a0a19d17f0f997f8 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-3edc0df4baab4064a0a19d17f0f997f82025-02-04T05:28:05ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15373031537303Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional studyYue-Yang Zhang0Yue-Yang Zhang1Yue-Yang Zhang2Yue-Yang Zhang3Yue-Yang Zhang4Xiao-Yu Yang5Xiao-Yu Yang6Xiao-Yu Yang7Xiao-Yu Yang8Xiao-Yu Yang9Qin Wan10Qin Wan11Qin Wan12Qin Wan13Qin Wan14Department of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMetabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, ChinaSichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, ChinaCardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, ChinaBackgroundThe Atherogenic Index of Plasma (AIP) was originally developed primarily as a marker for assessing atherosclerosis. Consequently, this study investigates the potential association between AIP and type 2 diabetic complications through a cross-sectional design.MethodsThe National Metabolic Management Center(MMC) serves as a comprehensive platform dedicated to the establishment of standardized protocols for the diagnosis, treatment, and long-term follow-up of metabolic diseases. Following the relevant inclusion and exclusion criteria, a total of 3,094 patients were enrolled for subsequent analysis. In this study, logistic regression, restricted cubic splines, and subgroup analyses were employed to evaluate the association between the AIP and four major complications of type 2 diabetes, namely, type 2 diabetes with carotid atherosclerosis (DA), diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN).ResultsThe logistic regression results demonstrate that in the fully adjusted model, each SD increase in AIP correlates with an elevated risk of type 2 diabetic kidney disease (DKD), with the risk of kidney damage intensifying alongside higher AIP groupings. The RCS analysis and subgroup analyses similarly revealed a dose-response relationship between AIP levels and the risk of DKD. Furthermore, the AIP was not found to be statistically significantly associated with DA, DR,and DPN.ConclusionsThe AIP may serve as a valuable predictive indicator for evaluating kidney damage in patients with type 2 diabetes, and regular screening of AIP in this population could provide significant benefits in the prevention of DKD.https://www.frontiersin.org/articles/10.3389/fendo.2025.1537303/fullatherogenic index of plasmatype 2 diabetesdiabetic complicationsmetabolic management centercross-sectional study |
| spellingShingle | Yue-Yang Zhang Yue-Yang Zhang Yue-Yang Zhang Yue-Yang Zhang Yue-Yang Zhang Xiao-Yu Yang Xiao-Yu Yang Xiao-Yu Yang Xiao-Yu Yang Xiao-Yu Yang Qin Wan Qin Wan Qin Wan Qin Wan Qin Wan Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study Frontiers in Endocrinology atherogenic index of plasma type 2 diabetes diabetic complications metabolic management center cross-sectional study |
| title | Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study |
| title_full | Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study |
| title_fullStr | Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study |
| title_full_unstemmed | Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study |
| title_short | Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study |
| title_sort | association between atherogenic index of plasma and type 2 diabetic complications a cross sectional study |
| topic | atherogenic index of plasma type 2 diabetes diabetic complications metabolic management center cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1537303/full |
| work_keys_str_mv | AT yueyangzhang associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT yueyangzhang associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT yueyangzhang associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT yueyangzhang associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT yueyangzhang associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT xiaoyuyang associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT xiaoyuyang associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT xiaoyuyang associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT xiaoyuyang associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT xiaoyuyang associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT qinwan associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT qinwan associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT qinwan associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT qinwan associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy AT qinwan associationbetweenatherogenicindexofplasmaandtype2diabeticcomplicationsacrosssectionalstudy |