Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional Status
Purpose. The purpose of this review was to identify the best solution for rapid and noninvasive diagnosis and long-term monitoring of patients affected by inflammatory gastrointestinal diseases, colon and gastric cancer, obesity in correlation to diet, and breast milk to evaluate exposure to VOCs in...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/7247802 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558307958587392 |
|---|---|
| author | Mariangela Rondanelli Federica Perdoni Vittoria Infantino Milena Anna Faliva Gabriella Peroni Giancarlo Iannello Mara Nichetti Tariq A. Alalwan Simone Perna Clementina Cocuzza |
| author_facet | Mariangela Rondanelli Federica Perdoni Vittoria Infantino Milena Anna Faliva Gabriella Peroni Giancarlo Iannello Mara Nichetti Tariq A. Alalwan Simone Perna Clementina Cocuzza |
| author_sort | Mariangela Rondanelli |
| collection | DOAJ |
| description | Purpose. The purpose of this review was to identify the best solution for rapid and noninvasive diagnosis and long-term monitoring of patients affected by inflammatory gastrointestinal diseases, colon and gastric cancer, obesity in correlation to diet, and breast milk to evaluate exposure to VOCs in women and infants. Methods. This review included 20 previously published eligible studies. VOC analysis has allowed us to highlight differences in lifestyles, intestinal microbiota, and metabolism. New innovative methods have been described that allow the detection and quantification of a broad spectrum of metabolites present in exhaled breath even at very low levels, some of which have been shown to be indicators of pathological conditions. Results. Five studies were analyzed that involved VOC analysis in relation to type of diet. All of them showed that the type of diet can have an impact on metabolites excreted and therefore can be a useful tool in the nutritional studies related to metabolism and health and disease status. Two studies concerned VOC analysis in inflammatory bowel diseases, and the results showed that VOCs can distinguish active disease from remission; VOC profile is clearly different in patients. In particular, C15H30 1-pentadecene, 3-methyl-1-butanal, octane, acetic acid, alpha-pinene, and m-cymene are elevated in active ulcerative colitis. Four studies examined VOCs in gastric and colorectal tumors showing a change in metabolic biomarkers of cancer patients compared to the control group. Finally, the study of VOCs in breast milk has improved the understanding of the potential health risks of exposure of children to chemical pollutants. Conclusions. VOC analysis allowed to highlight differences in behavior, lifestyle, and metabolism of individuals. Analytical methods are continuously developed to allow for better detection and quantification of metabolites, thus enabling the detection of a broader spectrum of pathophysiology and disease biomarkers. |
| format | Article |
| id | doaj-art-3ed1d9672f7d4842bcb2db2aa86d1c99 |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-3ed1d9672f7d4842bcb2db2aa86d1c992025-02-03T01:32:38ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732019-01-01201910.1155/2019/72478027247802Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional StatusMariangela Rondanelli0Federica Perdoni1Vittoria Infantino2Milena Anna Faliva3Gabriella Peroni4Giancarlo Iannello5Mara Nichetti6Tariq A. Alalwan7Simone Perna8Clementina Cocuzza9IRCCS Mondino Foundation, Pavia 27100, ItalyEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, Pavia 27100, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari 70121, ItalyEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, Pavia 27100, ItalyEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, Pavia 27100, ItalyGeneral Management, Azienda di Servizi alla Persona “Istituto Santa Margherita”, Pavia 27100, ItalyEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, Pavia 27100, ItalyDepartment of Biology, College of Science, University of Bahrain, Sakhir Campus P.O. Box 32038, Zallaq, BahrainDepartment of Biology, College of Science, University of Bahrain, Sakhir Campus P.O. Box 32038, Zallaq, BahrainDepartment of Medicine and Surgery, University of Milano-Bicocca, Milano 20126, ItalyPurpose. The purpose of this review was to identify the best solution for rapid and noninvasive diagnosis and long-term monitoring of patients affected by inflammatory gastrointestinal diseases, colon and gastric cancer, obesity in correlation to diet, and breast milk to evaluate exposure to VOCs in women and infants. Methods. This review included 20 previously published eligible studies. VOC analysis has allowed us to highlight differences in lifestyles, intestinal microbiota, and metabolism. New innovative methods have been described that allow the detection and quantification of a broad spectrum of metabolites present in exhaled breath even at very low levels, some of which have been shown to be indicators of pathological conditions. Results. Five studies were analyzed that involved VOC analysis in relation to type of diet. All of them showed that the type of diet can have an impact on metabolites excreted and therefore can be a useful tool in the nutritional studies related to metabolism and health and disease status. Two studies concerned VOC analysis in inflammatory bowel diseases, and the results showed that VOCs can distinguish active disease from remission; VOC profile is clearly different in patients. In particular, C15H30 1-pentadecene, 3-methyl-1-butanal, octane, acetic acid, alpha-pinene, and m-cymene are elevated in active ulcerative colitis. Four studies examined VOCs in gastric and colorectal tumors showing a change in metabolic biomarkers of cancer patients compared to the control group. Finally, the study of VOCs in breast milk has improved the understanding of the potential health risks of exposure of children to chemical pollutants. Conclusions. VOC analysis allowed to highlight differences in behavior, lifestyle, and metabolism of individuals. Analytical methods are continuously developed to allow for better detection and quantification of metabolites, thus enabling the detection of a broader spectrum of pathophysiology and disease biomarkers.http://dx.doi.org/10.1155/2019/7247802 |
| spellingShingle | Mariangela Rondanelli Federica Perdoni Vittoria Infantino Milena Anna Faliva Gabriella Peroni Giancarlo Iannello Mara Nichetti Tariq A. Alalwan Simone Perna Clementina Cocuzza Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional Status Journal of Analytical Methods in Chemistry |
| title | Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional Status |
| title_full | Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional Status |
| title_fullStr | Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional Status |
| title_full_unstemmed | Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional Status |
| title_short | Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional Status |
| title_sort | volatile organic compounds as biomarkers of gastrointestinal diseases and nutritional status |
| url | http://dx.doi.org/10.1155/2019/7247802 |
| work_keys_str_mv | AT mariangelarondanelli volatileorganiccompoundsasbiomarkersofgastrointestinaldiseasesandnutritionalstatus AT federicaperdoni volatileorganiccompoundsasbiomarkersofgastrointestinaldiseasesandnutritionalstatus AT vittoriainfantino volatileorganiccompoundsasbiomarkersofgastrointestinaldiseasesandnutritionalstatus AT milenaannafaliva volatileorganiccompoundsasbiomarkersofgastrointestinaldiseasesandnutritionalstatus AT gabriellaperoni volatileorganiccompoundsasbiomarkersofgastrointestinaldiseasesandnutritionalstatus AT giancarloiannello volatileorganiccompoundsasbiomarkersofgastrointestinaldiseasesandnutritionalstatus AT maranichetti volatileorganiccompoundsasbiomarkersofgastrointestinaldiseasesandnutritionalstatus AT tariqaalalwan volatileorganiccompoundsasbiomarkersofgastrointestinaldiseasesandnutritionalstatus AT simoneperna volatileorganiccompoundsasbiomarkersofgastrointestinaldiseasesandnutritionalstatus AT clementinacocuzza volatileorganiccompoundsasbiomarkersofgastrointestinaldiseasesandnutritionalstatus |