Role of Microglia in CNS Autoimmunity
Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world. The disease is characterized histologically by the infiltration of encephalitogenic TH1/TH17-polarized CD4+ T cells, B cells, and a plethora of myeloid cells, resulting in severe d...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/208093 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550613652602880 |
|---|---|
| author | Tobias Goldmann Marco Prinz |
| author_facet | Tobias Goldmann Marco Prinz |
| author_sort | Tobias Goldmann |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world. The disease is characterized histologically by the infiltration of encephalitogenic TH1/TH17-polarized CD4+ T cells, B cells, and a plethora of myeloid cells, resulting in severe demyelination ultimately leading to a degeneration of neuronal structures. These pathological processes are substantially modulated by microglia, the resident immune competent cells of the CNS. In this overview, we summarize the current knowledge regarding the highly diverse and complex function of microglia during CNS autoimmunity in either promoting tissue injury or tissue repair. Hence, understanding microglia involvement in MS offers new exciting paths for therapeutic intervention. |
| format | Article |
| id | doaj-art-3eca93bb406e4e53b1774242afe84cac |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-3eca93bb406e4e53b1774242afe84cac2025-02-03T06:06:13ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/208093208093Role of Microglia in CNS AutoimmunityTobias Goldmann0Marco Prinz1Institute of Neuropathology, University of Freiburg, Breisacher Straße 64, 79106 Freiburg, GermanyInstitute of Neuropathology, University of Freiburg, Breisacher Straße 64, 79106 Freiburg, GermanyMultiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world. The disease is characterized histologically by the infiltration of encephalitogenic TH1/TH17-polarized CD4+ T cells, B cells, and a plethora of myeloid cells, resulting in severe demyelination ultimately leading to a degeneration of neuronal structures. These pathological processes are substantially modulated by microglia, the resident immune competent cells of the CNS. In this overview, we summarize the current knowledge regarding the highly diverse and complex function of microglia during CNS autoimmunity in either promoting tissue injury or tissue repair. Hence, understanding microglia involvement in MS offers new exciting paths for therapeutic intervention.http://dx.doi.org/10.1155/2013/208093 |
| spellingShingle | Tobias Goldmann Marco Prinz Role of Microglia in CNS Autoimmunity Clinical and Developmental Immunology |
| title | Role of Microglia in CNS Autoimmunity |
| title_full | Role of Microglia in CNS Autoimmunity |
| title_fullStr | Role of Microglia in CNS Autoimmunity |
| title_full_unstemmed | Role of Microglia in CNS Autoimmunity |
| title_short | Role of Microglia in CNS Autoimmunity |
| title_sort | role of microglia in cns autoimmunity |
| url | http://dx.doi.org/10.1155/2013/208093 |
| work_keys_str_mv | AT tobiasgoldmann roleofmicrogliaincnsautoimmunity AT marcoprinz roleofmicrogliaincnsautoimmunity |