Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila
Abstract The Drosophila visual system is a powerful model to study the development of neural circuits. Lobula columnar neurons-LCNs are visual output neurons that encode visual features relevant to natural behavior. There are ~20 classes of LCNs forming non-overlapping synaptic optic glomeruli in th...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56059-7 |
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| author | Rana Naja El-Danaf Katarina Kapuralin Raghuvanshi Rajesh Félix Simon Nizar Drou Filipe Pinto-Teixeira Mehmet Neset Özel Claude Desplan |
| author_facet | Rana Naja El-Danaf Katarina Kapuralin Raghuvanshi Rajesh Félix Simon Nizar Drou Filipe Pinto-Teixeira Mehmet Neset Özel Claude Desplan |
| author_sort | Rana Naja El-Danaf |
| collection | DOAJ |
| description | Abstract The Drosophila visual system is a powerful model to study the development of neural circuits. Lobula columnar neurons-LCNs are visual output neurons that encode visual features relevant to natural behavior. There are ~20 classes of LCNs forming non-overlapping synaptic optic glomeruli in the brain. To address their origin, we used single-cell mRNA sequencing to define the transcriptome of LCN subtypes and identified lines that are expressed throughout their development. We show that LCNs originate from stem cells in four distinct brain regions exhibiting different modes of neurogenesis, including the ventral and dorsal tips of the outer proliferation center, the ventral superficial inner proliferation center and the central brain. We show that this convergence of similar neurons illustrates the complexity of generating neuronal diversity, and likely reflects the evolutionary origin of each subtype that detects a specific visual feature and might influence behaviors specific to each species. |
| format | Article |
| id | doaj-art-3eb4cb836b1747cdb0ddbf44bcbacaf9 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-3eb4cb836b1747cdb0ddbf44bcbacaf92025-01-19T12:32:11ZengNature PortfolioNature Communications2041-17232025-01-0116111510.1038/s41467-025-56059-7Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in DrosophilaRana Naja El-Danaf0Katarina Kapuralin1Raghuvanshi Rajesh2Félix Simon3Nizar Drou4Filipe Pinto-Teixeira5Mehmet Neset Özel6Claude Desplan7Center for Genomics and Systems Biology (CGSB), New York University Abu DhabiCenter for Genomics and Systems Biology (CGSB), New York University Abu DhabiCenter for Genomics and Systems Biology (CGSB), New York University Abu DhabiDepartment of Biology, New York UniversityCenter for Genomics and Systems Biology (CGSB), New York University Abu DhabiCenter for Genomics and Systems Biology (CGSB), New York University Abu DhabiDepartment of Biology, New York UniversityCenter for Genomics and Systems Biology (CGSB), New York University Abu DhabiAbstract The Drosophila visual system is a powerful model to study the development of neural circuits. Lobula columnar neurons-LCNs are visual output neurons that encode visual features relevant to natural behavior. There are ~20 classes of LCNs forming non-overlapping synaptic optic glomeruli in the brain. To address their origin, we used single-cell mRNA sequencing to define the transcriptome of LCN subtypes and identified lines that are expressed throughout their development. We show that LCNs originate from stem cells in four distinct brain regions exhibiting different modes of neurogenesis, including the ventral and dorsal tips of the outer proliferation center, the ventral superficial inner proliferation center and the central brain. We show that this convergence of similar neurons illustrates the complexity of generating neuronal diversity, and likely reflects the evolutionary origin of each subtype that detects a specific visual feature and might influence behaviors specific to each species.https://doi.org/10.1038/s41467-025-56059-7 |
| spellingShingle | Rana Naja El-Danaf Katarina Kapuralin Raghuvanshi Rajesh Félix Simon Nizar Drou Filipe Pinto-Teixeira Mehmet Neset Özel Claude Desplan Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila Nature Communications |
| title | Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila |
| title_full | Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila |
| title_fullStr | Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila |
| title_full_unstemmed | Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila |
| title_short | Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila |
| title_sort | morphological and functional convergence of visual projection neurons from diverse neurogenic origins in drosophila |
| url | https://doi.org/10.1038/s41467-025-56059-7 |
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