ASSESSMENT OF CYTOKINE LEVEL IN BLOOD SERUM IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION IN THE FIRST TRIMESTER OF PREGNANCY
Purpose of the study – to assess the content of cytokines IL-8, IL-1b and MCP-1 in the first trimester of pregnancy in women with chronic arterial hypertension. Materials and methods. The study included patients aged 18-45 years at 10-13 weeks of pregnancy. The main group – 46 pregnant women with c...
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| Format: | Article |
| Language: | Russian |
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The Publishing House Medicine and Enlightenment
2024-11-01
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| Series: | Мать и дитя в Кузбассе |
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| Online Access: | https://mednauki.ru/index.php/MD/article/view/1147 |
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| author | Лариса Дмитриевна Андосова Анна Алексеевна Дмитриева Людмила Васильевна Боровкова Светлана Олеговна Колобова Ксения Андреевна Шахова Юлия Рудольфовна Тихомирова Александр Алексеевич Туличев Людмила Александровна Чичкова |
| author_facet | Лариса Дмитриевна Андосова Анна Алексеевна Дмитриева Людмила Васильевна Боровкова Светлана Олеговна Колобова Ксения Андреевна Шахова Юлия Рудольфовна Тихомирова Александр Алексеевич Туличев Людмила Александровна Чичкова |
| author_sort | Лариса Дмитриевна Андосова |
| collection | DOAJ |
| description | Purpose of the study – to assess the content of cytokines IL-8, IL-1b and MCP-1 in the first trimester of pregnancy in women with chronic arterial hypertension.
Materials and methods. The study included patients aged 18-45 years at 10-13 weeks of pregnancy. The main group – 46 pregnant women with chronic arterial hypertension (stage I hypertension), the control group – 30 healthy pregnant women. Cytokine levels were determined by enzyme-linked immunosorbent assay.
Results. The results of the study revealed that women with chronic arterial hypertension had statistically significantly lower levels of IL-8 and MCP-1. It has been established that in order to maintain trophoblast function, inflammatory processes in the intervillous space are weakened.
Conclusion. The cytokine MCP-1 can be considered as a marker of the development of preeclampsia. Further study of its significance is necessary in a larger sample of patients and in correlation with other markers. |
| format | Article |
| id | doaj-art-3eb41a806e2d407d97c52432f5f2bbd4 |
| institution | Kabale University |
| issn | 1991-010X 2542-0968 |
| language | Russian |
| publishDate | 2024-11-01 |
| publisher | The Publishing House Medicine and Enlightenment |
| record_format | Article |
| series | Мать и дитя в Кузбассе |
| spelling | doaj-art-3eb41a806e2d407d97c52432f5f2bbd42025-02-03T15:55:08ZrusThe Publishing House Medicine and EnlightenmentМать и дитя в Кузбассе1991-010X2542-09682024-11-012541217983ASSESSMENT OF CYTOKINE LEVEL IN BLOOD SERUM IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION IN THE FIRST TRIMESTER OF PREGNANCYЛариса Дмитриевна Андосова0Анна Алексеевна Дмитриева1Людмила Васильевна Боровкова2Светлана Олеговна Колобова3Ксения Андреевна Шахова4Юлия Рудольфовна Тихомирова5Александр Алексеевич Туличев6Людмила Александровна Чичкова7ФГБОУ ВО ПИМУ Минздрава России, г. Нижний НовгородФГБОУ ВО ПИМУ Минздрава России, г. Нижний НовгородФГБОУ ВО ПИМУ Минздрава России, г. Нижний НовгородФГБОУ ВО ПИМУ Минздрава России, г. Нижний НовгородФГБОУ ВО ПИМУ Минздрава России, г. Нижний НовгородФГБОУ ВО ПИМУ Минздрава России, г. Нижний НовгородФГБОУ ВО ПИМУ Минздрава России, г. Нижний НовгородФГБОУ ВО ПИМУ Минздрава России, г. Нижний НовгородPurpose of the study – to assess the content of cytokines IL-8, IL-1b and MCP-1 in the first trimester of pregnancy in women with chronic arterial hypertension. Materials and methods. The study included patients aged 18-45 years at 10-13 weeks of pregnancy. The main group – 46 pregnant women with chronic arterial hypertension (stage I hypertension), the control group – 30 healthy pregnant women. Cytokine levels were determined by enzyme-linked immunosorbent assay. Results. The results of the study revealed that women with chronic arterial hypertension had statistically significantly lower levels of IL-8 and MCP-1. It has been established that in order to maintain trophoblast function, inflammatory processes in the intervillous space are weakened. Conclusion. The cytokine MCP-1 can be considered as a marker of the development of preeclampsia. Further study of its significance is necessary in a larger sample of patients and in correlation with other markers.https://mednauki.ru/index.php/MD/article/view/1147гипертензивные расстройствахроническая артериальная гипертензияинтерлейкин-8моноцитарный хемотаксический пептид-1 |
| spellingShingle | Лариса Дмитриевна Андосова Анна Алексеевна Дмитриева Людмила Васильевна Боровкова Светлана Олеговна Колобова Ксения Андреевна Шахова Юлия Рудольфовна Тихомирова Александр Алексеевич Туличев Людмила Александровна Чичкова ASSESSMENT OF CYTOKINE LEVEL IN BLOOD SERUM IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION IN THE FIRST TRIMESTER OF PREGNANCY Мать и дитя в Кузбассе гипертензивные расстройства хроническая артериальная гипертензия интерлейкин-8 моноцитарный хемотаксический пептид-1 |
| title | ASSESSMENT OF CYTOKINE LEVEL IN BLOOD SERUM IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION IN THE FIRST TRIMESTER OF PREGNANCY |
| title_full | ASSESSMENT OF CYTOKINE LEVEL IN BLOOD SERUM IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION IN THE FIRST TRIMESTER OF PREGNANCY |
| title_fullStr | ASSESSMENT OF CYTOKINE LEVEL IN BLOOD SERUM IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION IN THE FIRST TRIMESTER OF PREGNANCY |
| title_full_unstemmed | ASSESSMENT OF CYTOKINE LEVEL IN BLOOD SERUM IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION IN THE FIRST TRIMESTER OF PREGNANCY |
| title_short | ASSESSMENT OF CYTOKINE LEVEL IN BLOOD SERUM IN PREGNANT WOMEN WITH CHRONIC ARTERIAL HYPERTENSION IN THE FIRST TRIMESTER OF PREGNANCY |
| title_sort | assessment of cytokine level in blood serum in pregnant women with chronic arterial hypertension in the first trimester of pregnancy |
| topic | гипертензивные расстройства хроническая артериальная гипертензия интерлейкин-8 моноцитарный хемотаксический пептид-1 |
| url | https://mednauki.ru/index.php/MD/article/view/1147 |
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