Exploiting CRISPR/Cas system in controlling antibiotic resistance of bacteria
The emergence and spread of antimicrobial resistance is a threat to human health, therefore there is a need to explore new strategies to combat antibiotic-resistant bacteria. Antimicrobial resistance genes are mainly transmitted through horizontal gene transfer (HGT) mediated by transposable element...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tabriz: Hamid Allahverdipour, 2024-
2024-07-01
|
| Series: | BioSocial Health Journal |
| Subjects: | |
| Online Access: | https://biosocialhealthjournal.com/PDF/bshj-1-61.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The emergence and spread of antimicrobial resistance is a threat to human health, therefore there is a need to explore new strategies to combat antibiotic-resistant bacteria. Antimicrobial resistance genes are mainly transmitted through horizontal gene transfer (HGT) mediated by transposable elements, phages, and plasmids, which leads to the emergence of multidrug-resistant bacteria. Clustered Regularly interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated proteins (Cas) protect archaebacteria and eubacteria from potentially harmful foreign DNA such as plasmids, transposable elements, and phages. Several studies have introduced the CRISPR/Cas system as an innovative and effective strategy to trigger antibiotic resistance and virulent genes in bacteria. Therefore, this study aimed to introduce the CRISPR-Cas system in controlling antibiotic resistance of bacteria. We hope exploiting CRISPR/Cas could provide a bright future for the treatment of disastrous infections with resistant and virulent organisms. |
|---|---|
| ISSN: | 3060-6268 |