Association of vancomycin trough levels, AUC and AUC/MIC ratios with clinical outcomes in patients with enterococcal bacteremia: a prospective cohort study

Association of vancomycin trough levels, AUC and AUC/MIC ratios with clinical outcomes in patients with enterococcal bacteremia: a prospective cohort study

Abstract Background The optimal vancomycin pharmacokinetic/pharmacodynamic (PK/PD) targets for successful treatment of enterococcal infections remain controversial. To clarify these targets, this study investigated the association of the vancomycin area under the curve (AUC), the AUC/minimum inhibit...

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Main Authors: Eda Kubra Sel, Berfu Tufan, Gundag Kupra Atagun, Vildan Avkan Oguz, Ozgen Alpay Ozbek, Mukaddes Gumustekin, Serife Reyhan Ucku, Ayse Gelal
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Infectious Diseases
Subjects:
Vancomycin
Enterococcus bacteremia
Serum trough level
Area under the curve/Minimum inhibitory concentration
AUC/MIC
Online Access:https://doi.org/10.1186/s12879-025-11400-9
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