Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sld mice
STUDIES were carried out to evaluate the impact of a high-fat dietary regimen on aortic wall thickness, peripheral blood leukocyte profile, and plasma cholesterol and triglyceride levels in the mast cell-deficient Sl/Sld mouse. The results demonstrated that the mean aortic wall thickness of Sl/Sld m...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09629350400008794 |
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| author | Kottarappat N. Dileepan Thomas P. Johnston Yuai Li Ossama Tawfik Daniel J. Stechschulte |
| author_facet | Kottarappat N. Dileepan Thomas P. Johnston Yuai Li Ossama Tawfik Daniel J. Stechschulte |
| author_sort | Kottarappat N. Dileepan |
| collection | DOAJ |
| description | STUDIES were carried out to evaluate the impact of a high-fat dietary regimen on aortic wall thickness, peripheral blood leukocyte profile, and plasma cholesterol and triglyceride levels in the mast cell-deficient Sl/Sld mouse. The results demonstrated that the mean aortic wall thickness of Sl/Sld mice was significantly higher than their normal littermates, and were increased in both genotypes after a 17-day high-fat regimen. In comparison with normal littermates, Sl/Sld genotypes had elevated levels of plasma triglycerides with normal levels of plasma cholesterol, and the high-fat diet markedly lowered the triglyceride levels. Total peripheral blood leukocytes, the monocyte and granulocyte counts, and hemoglobin levels were significantly lower in Sl/Sld mice, although the number of lymphocytes, eosinophils and basophils were the same in both genotypes. Interestingly, the high-fat diet regimen elevated leukocyte counts and the number of monocytes and granulocytes in Sl/Sld mice. |
| format | Article |
| id | doaj-art-3e88824820334023b4487c7791720aca |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3e88824820334023b4487c7791720aca2025-02-03T01:22:44ZengWileyMediators of Inflammation0962-93511466-18612004-01-01135-633534110.1080/09629350400008794Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sld miceKottarappat N. Dileepan0Thomas P. Johnston1Yuai Li2Ossama Tawfik3Daniel J. Stechschulte4Division of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USADivision of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, MO 64110, USADivision of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USADivision of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USASTUDIES were carried out to evaluate the impact of a high-fat dietary regimen on aortic wall thickness, peripheral blood leukocyte profile, and plasma cholesterol and triglyceride levels in the mast cell-deficient Sl/Sld mouse. The results demonstrated that the mean aortic wall thickness of Sl/Sld mice was significantly higher than their normal littermates, and were increased in both genotypes after a 17-day high-fat regimen. In comparison with normal littermates, Sl/Sld genotypes had elevated levels of plasma triglycerides with normal levels of plasma cholesterol, and the high-fat diet markedly lowered the triglyceride levels. Total peripheral blood leukocytes, the monocyte and granulocyte counts, and hemoglobin levels were significantly lower in Sl/Sld mice, although the number of lymphocytes, eosinophils and basophils were the same in both genotypes. Interestingly, the high-fat diet regimen elevated leukocyte counts and the number of monocytes and granulocytes in Sl/Sld mice.http://dx.doi.org/10.1080/09629350400008794High-fat dietStem cell factor deficiencyMast cell deficiencyIntima media thicknessHypertriglyceridemia. |
| spellingShingle | Kottarappat N. Dileepan Thomas P. Johnston Yuai Li Ossama Tawfik Daniel J. Stechschulte Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sld mice Mediators of Inflammation High-fat diet Stem cell factor deficiency Mast cell deficiency Intima media thickness Hypertriglyceridemia. |
| title | Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sld mice |
| title_full | Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sld mice |
| title_fullStr | Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sld mice |
| title_full_unstemmed | Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sld mice |
| title_short | Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sld mice |
| title_sort | deranged aortic intima media thickness plasma triglycerides and granulopoiesis in sl sld mice |
| topic | High-fat diet Stem cell factor deficiency Mast cell deficiency Intima media thickness Hypertriglyceridemia. |
| url | http://dx.doi.org/10.1080/09629350400008794 |
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