Abnormal Thyroid Function Laboratory Results Caused by Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressant Treatment

Mental health issues, especially depressive disorders, are major burdens to the health care systems. This has been more pronounced since the onset of the COVID-19 pandemic. Selective serotonin reuptake inhibitors (SSRIs) are often prescribed for depression. Uncommonly appreciated, however, are the a...

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Main Authors: Huijuan Liao, David S. Rosenthal, Salini C. Kumar
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Case Reports in Psychiatry
Online Access:http://dx.doi.org/10.1155/2023/7170564
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author Huijuan Liao
David S. Rosenthal
Salini C. Kumar
author_facet Huijuan Liao
David S. Rosenthal
Salini C. Kumar
author_sort Huijuan Liao
collection DOAJ
description Mental health issues, especially depressive disorders, are major burdens to the health care systems. This has been more pronounced since the onset of the COVID-19 pandemic. Selective serotonin reuptake inhibitors (SSRIs) are often prescribed for depression. Uncommonly appreciated, however, are the adverse effects these agents may have on thyroid function laboratory test results as well as the clinical thyroidal functional status of such patients, which may lead to erroneous diagnoses and inappropriate treatments. We report on a depressed woman who developed abnormal thyroid biochemical laboratory reports during fluoxetine therapy. After changing to the serotonin and norepinephrine reuptake inhibitor (SNRI) venlafaxine, the thyroid laboratory reports were normalized. In light of this, we wish to alert treating clinicians to this potential significant adverse effect.
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spelling doaj-art-3e854235cb274f109d9a9c3594dfc3292025-02-03T05:44:20ZengWileyCase Reports in Psychiatry2090-68382023-01-01202310.1155/2023/7170564Abnormal Thyroid Function Laboratory Results Caused by Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressant TreatmentHuijuan Liao0David S. Rosenthal1Salini C. Kumar2Division of EndocrinologyDivision of EndocrinologyDivision of EndocrinologyMental health issues, especially depressive disorders, are major burdens to the health care systems. This has been more pronounced since the onset of the COVID-19 pandemic. Selective serotonin reuptake inhibitors (SSRIs) are often prescribed for depression. Uncommonly appreciated, however, are the adverse effects these agents may have on thyroid function laboratory test results as well as the clinical thyroidal functional status of such patients, which may lead to erroneous diagnoses and inappropriate treatments. We report on a depressed woman who developed abnormal thyroid biochemical laboratory reports during fluoxetine therapy. After changing to the serotonin and norepinephrine reuptake inhibitor (SNRI) venlafaxine, the thyroid laboratory reports were normalized. In light of this, we wish to alert treating clinicians to this potential significant adverse effect.http://dx.doi.org/10.1155/2023/7170564
spellingShingle Huijuan Liao
David S. Rosenthal
Salini C. Kumar
Abnormal Thyroid Function Laboratory Results Caused by Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressant Treatment
Case Reports in Psychiatry
title Abnormal Thyroid Function Laboratory Results Caused by Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressant Treatment
title_full Abnormal Thyroid Function Laboratory Results Caused by Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressant Treatment
title_fullStr Abnormal Thyroid Function Laboratory Results Caused by Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressant Treatment
title_full_unstemmed Abnormal Thyroid Function Laboratory Results Caused by Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressant Treatment
title_short Abnormal Thyroid Function Laboratory Results Caused by Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressant Treatment
title_sort abnormal thyroid function laboratory results caused by selective serotonin reuptake inhibitor ssri antidepressant treatment
url http://dx.doi.org/10.1155/2023/7170564
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AT davidsrosenthal abnormalthyroidfunctionlaboratoryresultscausedbyselectiveserotoninreuptakeinhibitorssriantidepressanttreatment
AT salinickumar abnormalthyroidfunctionlaboratoryresultscausedbyselectiveserotoninreuptakeinhibitorssriantidepressanttreatment