Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans
The Gram-positive organism Filifactor alocis is implicated in multiple oral diseases including periodontitis, and approximately 50% of known strains encode and produce a recently identified repeat-in-toxin (RTX) protein, FtxA, partly homologous to the Aggregatibacter actinomycetemcomitans leukotoxin...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1501028/full |
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| author | Zeinab Razooqi Nabil Khzam Nabil Khzam Mahina L’Hostis Georgios N. Belibasakis Anders Johansson Jan Oscarsson |
| author_facet | Zeinab Razooqi Nabil Khzam Nabil Khzam Mahina L’Hostis Georgios N. Belibasakis Anders Johansson Jan Oscarsson |
| author_sort | Zeinab Razooqi |
| collection | DOAJ |
| description | The Gram-positive organism Filifactor alocis is implicated in multiple oral diseases including periodontitis, and approximately 50% of known strains encode and produce a recently identified repeat-in-toxin (RTX) protein, FtxA, partly homologous to the Aggregatibacter actinomycetemcomitans leukotoxin. By assessing a longitudinal Ghanaian study population of adolescents, we recently identified a possible correlation between F. alocis levels, ftxA gene carriage, and progression of clinical attachment loss (CAL). To extend knowledge on the possible significance of F. alocis and its FtxA in periodontal disease, we have in the present work analyzed saliva samples in an independent cohort of periodontitis (n=156), collected at two private periodontal specialist practices in Perth, Western Australia. The present results corroborate that high loads of F. alocis and the presence of its ftxA gene together are associated with parameters of periodontal tissue destruction and severity. Moreover, among the individuals carrying A. actinomycetemcomitans, a majority also exhibited an ftxA-positive F. alocis, supporting the notion of the synergistic behavior of these two species. This emphasizes that F. alocis and its ftxA are involved in the pathogenesis of periodontitis and may have ecological roles, with diagnostic and prognostic implications for the disease. |
| format | Article |
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| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-3e837047f9234ca99d565952fc64d50e2025-01-22T07:12:00ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-01-011410.3389/fcimb.2024.15010281501028Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitansZeinab Razooqi0Nabil Khzam1Nabil Khzam2Mahina L’Hostis3Georgios N. Belibasakis4Anders Johansson5Jan Oscarsson6Department of Odontology, Umeå University, Umea, SwedenOral Health Centre of Western Australia, Dental School, The University of Western Australia, Perth, WA, AustraliaNK Periodontics, Perth, WA, AustraliaDepartment of Odontology, Umeå University, Umea, SwedenDivision of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, SwedenDepartment of Odontology, Umeå University, Umea, SwedenDepartment of Odontology, Umeå University, Umea, SwedenThe Gram-positive organism Filifactor alocis is implicated in multiple oral diseases including periodontitis, and approximately 50% of known strains encode and produce a recently identified repeat-in-toxin (RTX) protein, FtxA, partly homologous to the Aggregatibacter actinomycetemcomitans leukotoxin. By assessing a longitudinal Ghanaian study population of adolescents, we recently identified a possible correlation between F. alocis levels, ftxA gene carriage, and progression of clinical attachment loss (CAL). To extend knowledge on the possible significance of F. alocis and its FtxA in periodontal disease, we have in the present work analyzed saliva samples in an independent cohort of periodontitis (n=156), collected at two private periodontal specialist practices in Perth, Western Australia. The present results corroborate that high loads of F. alocis and the presence of its ftxA gene together are associated with parameters of periodontal tissue destruction and severity. Moreover, among the individuals carrying A. actinomycetemcomitans, a majority also exhibited an ftxA-positive F. alocis, supporting the notion of the synergistic behavior of these two species. This emphasizes that F. alocis and its ftxA are involved in the pathogenesis of periodontitis and may have ecological roles, with diagnostic and prognostic implications for the disease.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1501028/fullFilifactor alocisftxARTX toxinAggregatibacter actinomycetemcomitansperiodontitisclinical attachment loss (CAL) |
| spellingShingle | Zeinab Razooqi Nabil Khzam Nabil Khzam Mahina L’Hostis Georgios N. Belibasakis Anders Johansson Jan Oscarsson Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans Frontiers in Cellular and Infection Microbiology Filifactor alocis ftxA RTX toxin Aggregatibacter actinomycetemcomitans periodontitis clinical attachment loss (CAL) |
| title | Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans |
| title_full | Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans |
| title_fullStr | Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans |
| title_full_unstemmed | Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans |
| title_short | Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans |
| title_sort | prevalence of the oral pathogen filifactor alocis and its ftxa toxin related to clinical parameters and presence of aggregatibacter actinomycetemcomitans |
| topic | Filifactor alocis ftxA RTX toxin Aggregatibacter actinomycetemcomitans periodontitis clinical attachment loss (CAL) |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1501028/full |
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