Cough in pulmonary rehabilitation: a retrospective analysis of responders and nonresponders
Background Pulmonary rehabilitation (PR) is essential for people with chronic respiratory diseases (CRDs), yet its impact on cough-related quality of life (CR-QoL) remains unexplored. We assessed the effects of PR on CR-QoL, described the characteristics of responders and nonresponders to PR, and ex...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2025-03-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/11/2/00308-2024.full |
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| Summary: | Background
Pulmonary rehabilitation (PR) is essential for people with chronic respiratory diseases (CRDs), yet its impact on cough-related quality of life (CR-QoL) remains unexplored. We assessed the effects of PR on CR-QoL, described the characteristics of responders and nonresponders to PR, and explored determinants of responsiveness in this health domain in individuals with CRDs.
Methods
A retrospective study was conducted. We assessed CR-QoL using the Leicester Cough Questionnaire (LCQ) and the impact of the disease with the COPD Assessment Test (CAT), before and after PR. Cut-offs of <17.05 in LCQ total score and ≥10 in CAT were used to detect low CR-QoL and medium impact of the disease. Responders were defined as achieving a minimal clinically important difference (MCID) of ≥1.3 on the LCQ total score. Pre- versus post-PR analysis involved the t-test, Wilcoxon test or McNemar test and comparisons between groups included the independent t-test, Mann–Whitney U-test or Fisher's exact test. Logistic regression was employed to investigate factors influencing MCID achievement.
Results
135 participants with CRDs (39% females; age 68±10 years; 61% COPD; forced expiratory volume in 1 s (FEV1) % pred 62.6±23.0%) were included. After PR, significant improvements were observed in all LCQ domains and CAT. 31% of participants were identified as responders in the LCQ (36% females; age 66±10 years; 62% COPD; FEV1 % pred 60.0±22.3%), showcasing significant differences in the LCQ and CAT compared to nonresponders. People with low CR-QoL and medium/high impact of the disease at baseline were 11 and 4 times more likely to respond to PR in CR-QoL, respectively.
Conclusion
PR enhances CR-QoL. Identification of CR-QoL and disease impact traits at baseline offers insights to optimise this outcome responsiveness to PR. |
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| ISSN: | 2312-0541 |