Association of the number of minor hallucinations and well-structured visual hallucinations in Parkinson’s disease
Abstract Minor hallucinations (MH), comprising three subtypes (presence hallucinations, passage hallucinations, and visual illusions), typically emerge during the early stages of Parkinson’s disease (PD) and precede the onset of well-structured visual hallucinations (VH). Whether the number of MH is...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01106-9 |
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| author | Haiying Zhang Yang Zhao Yi Chen Yuanyuan Feng Bo Shen Shuangshuang Dong Jun Zhu Xu Jiang Dongfeng Li Yaning Chen Feng Han Li Zhang |
| author_facet | Haiying Zhang Yang Zhao Yi Chen Yuanyuan Feng Bo Shen Shuangshuang Dong Jun Zhu Xu Jiang Dongfeng Li Yaning Chen Feng Han Li Zhang |
| author_sort | Haiying Zhang |
| collection | DOAJ |
| description | Abstract Minor hallucinations (MH), comprising three subtypes (presence hallucinations, passage hallucinations, and visual illusions), typically emerge during the early stages of Parkinson’s disease (PD) and precede the onset of well-structured visual hallucinations (VH). Whether the number of MH is associated with VH in PD patients remains unclear. We investigated the association between the number of MH and VH in 372 PD patients. Log-binomial regressions showed that individuals with multiple MH had a significantly higher prevalence of VH (RR = 2.08, 95% CI: 1.11–3.90 for 2 MH; RR = 6.20, 95% CI: 3.40–11.31 for 3 MH), while those with only one MH had a similar VH prevalence compared to those without MH (RR = 1.08, 95% CI: 0.53–2.21). Women exhibited stronger associations than men. These findings emphasize the importance of quantifying MH subtypes when assessing hallucinations, though their potential utility as predictive markers of disease progression and targets for early intervention requires validation through longitudinal studies. |
| format | Article |
| id | doaj-art-3e6aa8d64b334057a65a79f5ae583672 |
| institution | DOAJ |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-3e6aa8d64b334057a65a79f5ae5836722025-08-20T03:07:26ZengNature Portfolionpj Parkinson's Disease2373-80572025-08-011111710.1038/s41531-025-01106-9Association of the number of minor hallucinations and well-structured visual hallucinations in Parkinson’s diseaseHaiying Zhang0Yang Zhao1Yi Chen2Yuanyuan Feng3Bo Shen4Shuangshuang Dong5Jun Zhu6Xu Jiang7Dongfeng Li8Yaning Chen9Feng Han10Li Zhang11Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical UniversitySchool of Pharmacy, Nanjing Medical UniversityDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityAbstract Minor hallucinations (MH), comprising three subtypes (presence hallucinations, passage hallucinations, and visual illusions), typically emerge during the early stages of Parkinson’s disease (PD) and precede the onset of well-structured visual hallucinations (VH). Whether the number of MH is associated with VH in PD patients remains unclear. We investigated the association between the number of MH and VH in 372 PD patients. Log-binomial regressions showed that individuals with multiple MH had a significantly higher prevalence of VH (RR = 2.08, 95% CI: 1.11–3.90 for 2 MH; RR = 6.20, 95% CI: 3.40–11.31 for 3 MH), while those with only one MH had a similar VH prevalence compared to those without MH (RR = 1.08, 95% CI: 0.53–2.21). Women exhibited stronger associations than men. These findings emphasize the importance of quantifying MH subtypes when assessing hallucinations, though their potential utility as predictive markers of disease progression and targets for early intervention requires validation through longitudinal studies.https://doi.org/10.1038/s41531-025-01106-9 |
| spellingShingle | Haiying Zhang Yang Zhao Yi Chen Yuanyuan Feng Bo Shen Shuangshuang Dong Jun Zhu Xu Jiang Dongfeng Li Yaning Chen Feng Han Li Zhang Association of the number of minor hallucinations and well-structured visual hallucinations in Parkinson’s disease npj Parkinson's Disease |
| title | Association of the number of minor hallucinations and well-structured visual hallucinations in Parkinson’s disease |
| title_full | Association of the number of minor hallucinations and well-structured visual hallucinations in Parkinson’s disease |
| title_fullStr | Association of the number of minor hallucinations and well-structured visual hallucinations in Parkinson’s disease |
| title_full_unstemmed | Association of the number of minor hallucinations and well-structured visual hallucinations in Parkinson’s disease |
| title_short | Association of the number of minor hallucinations and well-structured visual hallucinations in Parkinson’s disease |
| title_sort | association of the number of minor hallucinations and well structured visual hallucinations in parkinson s disease |
| url | https://doi.org/10.1038/s41531-025-01106-9 |
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