Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis

Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis

Abstract Fibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Little is known about what regulates the homeostatic functions of fibroblasts. Here, we perform RNA sequencing and identify a gene expression progra...

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Bibliographic Details
Main Authors: Heather J. Faust, Tan-Yun Cheng, Ilya Korsunsky, Gerald F. M. Watts, Shani T. Gal-Oz, William V. Trim, Suppawat Kongthong, Anna Helena Jonsson, Daimon P. Simmons, Fan Zhang, Robert Padera, Susan Chubinskaya, Accelerating Medicines Partnership: RA/SLE Network, Kevin Wei, Soumya Raychaudhuri, Lydia Lynch, D. Branch Moody, Michael B. Brenner
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-52586-x
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