Irisin mitigates osteoporotic-associated bone loss and gut dysbiosis in ovariectomized mice by modulating microbiota, metabolites, and intestinal barrier integrity

Irisin mitigates osteoporotic-associated bone loss and gut dysbiosis in ovariectomized mice by modulating microbiota, metabolites, and intestinal barrier integrity

Abstract Background Osteoporotic bone defects significantly affect patient health and quality of life. The gut-bone axis plays a crucial role in osteoporosis, and disruptions in gut microbiota are linked to systemic inflammation and compromised bone metabolism. Irisin, a myokine, has shown potential...

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Bibliographic Details
Main Authors: Yiran Wang, Huimin Deng, Zhihui Zhang, Hongbo Wu, Xiaofeng Wang, Zhiwen Zhang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Musculoskeletal Disorders
Subjects:
Irisin
Osteoporosis
Gut microbiota
Bone repair
Intestinal barrier integrity
Metabolomics
Online Access:https://doi.org/10.1186/s12891-025-08622-y
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