Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics
Gynecological cancers present significant treatment challenges due to drug resistance and adverse side effects. This review explores advancements in lysosomal escape mechanisms, essential for enhancing nano-therapeutic efficacy. Strategies such as pH-sensitive linkers and membrane fusion are examine...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Pharmaceutical Analysis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177924002168 |
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| author | Heng Wei Yingying Hao Jin Zhang Yue Qi Chong Feng Chen Zhang |
| author_facet | Heng Wei Yingying Hao Jin Zhang Yue Qi Chong Feng Chen Zhang |
| author_sort | Heng Wei |
| collection | DOAJ |
| description | Gynecological cancers present significant treatment challenges due to drug resistance and adverse side effects. This review explores advancements in lysosomal escape mechanisms, essential for enhancing nano-therapeutic efficacy. Strategies such as pH-sensitive linkers and membrane fusion are examined, showcasing their potential to improve therapeutic outcomes in ovarian, cervical, and uterine cancers. We delve into novel materials and strategies developed to bypass the lysosomal barrier, including pH-sensitive linkers, fusogenic lipids, and nanoparticles (NPs) engineered for endosomal disruption. Mechanisms such as the proton sponge effect, where NPs induce osmotic swelling and rupture of the lysosomal membrane, and membrane fusion, which facilitates the release of therapeutic agents directly into the cytoplasm, are explored in detail. These innovations not only promise to improve therapeutic outcomes but also minimize side effects, marking a significant step forward in the treatment of ovarian, cervical, and uterine cancers. By providing a comprehensive analysis of current advancements and their implications for clinical applications, this review sheds light on the potential of lysosomal escape strategies to revolutionize gynecological cancer treatment, setting the stage for future research and development in this vital area. |
| format | Article |
| id | doaj-art-3e4ba47201cf49a59806d74a42daab6e |
| institution | Kabale University |
| issn | 2095-1779 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj-art-3e4ba47201cf49a59806d74a42daab6e2025-01-30T05:13:59ZengElsevierJournal of Pharmaceutical Analysis2095-17792024-12-011412101119Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeuticsHeng Wei0Yingying Hao1Jin Zhang2Yue Qi3Chong Feng4Chen Zhang5Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 117004, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 117004, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 117004, ChinaCorresponding author.; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 117004, ChinaCorresponding author.; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 117004, ChinaCorresponding author.; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 117004, ChinaGynecological cancers present significant treatment challenges due to drug resistance and adverse side effects. This review explores advancements in lysosomal escape mechanisms, essential for enhancing nano-therapeutic efficacy. Strategies such as pH-sensitive linkers and membrane fusion are examined, showcasing their potential to improve therapeutic outcomes in ovarian, cervical, and uterine cancers. We delve into novel materials and strategies developed to bypass the lysosomal barrier, including pH-sensitive linkers, fusogenic lipids, and nanoparticles (NPs) engineered for endosomal disruption. Mechanisms such as the proton sponge effect, where NPs induce osmotic swelling and rupture of the lysosomal membrane, and membrane fusion, which facilitates the release of therapeutic agents directly into the cytoplasm, are explored in detail. These innovations not only promise to improve therapeutic outcomes but also minimize side effects, marking a significant step forward in the treatment of ovarian, cervical, and uterine cancers. By providing a comprehensive analysis of current advancements and their implications for clinical applications, this review sheds light on the potential of lysosomal escape strategies to revolutionize gynecological cancer treatment, setting the stage for future research and development in this vital area.http://www.sciencedirect.com/science/article/pii/S2095177924002168Gynecological cancersNano-therapeuticsLysosomal escapeEndosomal escapepH-sensitive nanoparticlesCancer nanotechnology |
| spellingShingle | Heng Wei Yingying Hao Jin Zhang Yue Qi Chong Feng Chen Zhang Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics Journal of Pharmaceutical Analysis Gynecological cancers Nano-therapeutics Lysosomal escape Endosomal escape pH-sensitive nanoparticles Cancer nanotechnology |
| title | Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics |
| title_full | Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics |
| title_fullStr | Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics |
| title_full_unstemmed | Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics |
| title_short | Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics |
| title_sort | advances in lysosomal escape mechanisms for gynecological cancer nano therapeutics |
| topic | Gynecological cancers Nano-therapeutics Lysosomal escape Endosomal escape pH-sensitive nanoparticles Cancer nanotechnology |
| url | http://www.sciencedirect.com/science/article/pii/S2095177924002168 |
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