Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator

Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator

Abstract Chromatin acetylation, a critical regulator of synaptic plasticity and memory processes, is thought to be altered in neurodegenerative diseases. Here, we demonstrate that spatial memory and plasticity (LTD, dendritic spine formation) deficits can be restored in a mouse model of tauopathy fo...

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Main Authors: Snehajyoti Chatterjee, Raphaelle Cassel, Anne Schneider‐Anthony, Karine Merienne, Brigitte Cosquer, Laura Tzeplaeff, Sarmistha Halder Sinha, Manoj Kumar, Piyush Chaturbedy, Muthusamy Eswaramoorthy, Stéphanie Le Gras, Céline Keime, Olivier Bousiges, Patrick Dutar, Petnoi Petsophonsakul, Claire Rampon, Jean‐Christophe Cassel, Luc Buée, David Blum, Tapas K Kundu, Anne‐Laurence Boutillier
Format: Article
Language:English
Published: Springer Nature 2018-10-01
Series:EMBO Molecular Medicine
Subjects:
acetylation
Alzheimer's disease
CREB‐binding protein
learning
transcription
Online Access:https://doi.org/10.15252/emmm.201708587
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