Clomiphene Citrate versus Clomiphene Citrate in combination with other drugs in Ovulation Induction in Patients with Polycystic Ovary Syndrome
Background: Polycystic ovary syndrome (PCOS) is the most prevalent cause of normogonadotrophic anovulation, also classified as World Health Organization group II anovulation. Objectives: The aim of this study was to compare the effectiveness and clinical outcomes of clomiphene citrate alone and wit...
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South Valley University, Faculty of Medicine
2025-07-01
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| Series: | SVU - International Journal of Medical Sciences |
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| Online Access: | https://svuijm.journals.ekb.eg/article_356800.html |
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| author | Mostafa Khodary Yasser Ahmed Abuelwafa Abdellatif Mahmoud Ibrahim Almolakab B- Alrashidy Sayed Ahmed Mohammed Taha |
| author_facet | Mostafa Khodary Yasser Ahmed Abuelwafa Abdellatif Mahmoud Ibrahim Almolakab B- Alrashidy Sayed Ahmed Mohammed Taha |
| author_sort | Mostafa Khodary |
| collection | DOAJ |
| description | Background: Polycystic ovary syndrome (PCOS) is the most prevalent cause of normogonadotrophic anovulation, also classified as World Health Organization group II anovulation.
Objectives: The aim of this study was to compare the effectiveness and clinical outcomes of clomiphene citrate alone and with different combinations (metformin , tamoxifen , letrozole and low dose gonadotrophins ) in induction of ovulation in women with PCOS.
Patients and methods: The Obstetrics and Gynecology department at Qena University Hospital, South Valley University, was the site of this randomized study. The study included 400 infertile cases with PCOS divided on 5 groups . The duration of the study ranged from 12-24 months.
Results: In the studied groups, group 4 (clomiphene and letrozole ) and group 5 (clomiphene and low dose gonadotrophins) had the highest ovulation rate which was 31.3 % , 41.3 % respectively and also the highest pregnancy rate which was 33.8 % for each group .
Conclusion: The combination of clomiphene and letrozole and clomiphene and gonadotrophins had proved to be the most effective , low cost infertility treatment in women with PCOS that offers high ovulation and pregnancy rates. |
| format | Article |
| id | doaj-art-3e39a76e51b44a959546dfea1f37b96d |
| institution | Kabale University |
| issn | 2735-427X 2636-3402 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | South Valley University, Faculty of Medicine |
| record_format | Article |
| series | SVU - International Journal of Medical Sciences |
| spelling | doaj-art-3e39a76e51b44a959546dfea1f37b96d2025-01-23T09:32:10ZengSouth Valley University, Faculty of MedicineSVU - International Journal of Medical Sciences2735-427X2636-34022025-07-017218https://doi.org/10.21608/svuijm.2023.194749.1534Clomiphene Citrate versus Clomiphene Citrate in combination with other drugs in Ovulation Induction in Patients with Polycystic Ovary SyndromeMostafa Khodary 0 Yasser Ahmed Abuelwafa Abdellatif 1 Mahmoud Ibrahim Almolakab B- Alrashidy 2 Sayed Ahmed Mohammed Taha 3Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt.Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt.Obstetrics and Gynecology Department, Faculty of Medicine, Al-Azhar University (Assuit Branch), Assiut, EgyptObstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt.Background: Polycystic ovary syndrome (PCOS) is the most prevalent cause of normogonadotrophic anovulation, also classified as World Health Organization group II anovulation. Objectives: The aim of this study was to compare the effectiveness and clinical outcomes of clomiphene citrate alone and with different combinations (metformin , tamoxifen , letrozole and low dose gonadotrophins ) in induction of ovulation in women with PCOS. Patients and methods: The Obstetrics and Gynecology department at Qena University Hospital, South Valley University, was the site of this randomized study. The study included 400 infertile cases with PCOS divided on 5 groups . The duration of the study ranged from 12-24 months. Results: In the studied groups, group 4 (clomiphene and letrozole ) and group 5 (clomiphene and low dose gonadotrophins) had the highest ovulation rate which was 31.3 % , 41.3 % respectively and also the highest pregnancy rate which was 33.8 % for each group . Conclusion: The combination of clomiphene and letrozole and clomiphene and gonadotrophins had proved to be the most effective , low cost infertility treatment in women with PCOS that offers high ovulation and pregnancy rates.https://svuijm.journals.ekb.eg/article_356800.htmlanovulation pcos clomiphene citrate tamoxifen metforminletrozole gonadotrophins ovulation induction endometrium |
| spellingShingle | Mostafa Khodary Yasser Ahmed Abuelwafa Abdellatif Mahmoud Ibrahim Almolakab B- Alrashidy Sayed Ahmed Mohammed Taha Clomiphene Citrate versus Clomiphene Citrate in combination with other drugs in Ovulation Induction in Patients with Polycystic Ovary Syndrome SVU - International Journal of Medical Sciences anovulation pcos clomiphene citrate tamoxifen metformin letrozole gonadotrophins ovulation induction endometrium |
| title | Clomiphene Citrate versus Clomiphene Citrate in combination with other drugs in Ovulation Induction in Patients with Polycystic Ovary Syndrome |
| title_full | Clomiphene Citrate versus Clomiphene Citrate in combination with other drugs in Ovulation Induction in Patients with Polycystic Ovary Syndrome |
| title_fullStr | Clomiphene Citrate versus Clomiphene Citrate in combination with other drugs in Ovulation Induction in Patients with Polycystic Ovary Syndrome |
| title_full_unstemmed | Clomiphene Citrate versus Clomiphene Citrate in combination with other drugs in Ovulation Induction in Patients with Polycystic Ovary Syndrome |
| title_short | Clomiphene Citrate versus Clomiphene Citrate in combination with other drugs in Ovulation Induction in Patients with Polycystic Ovary Syndrome |
| title_sort | clomiphene citrate versus clomiphene citrate in combination with other drugs in ovulation induction in patients with polycystic ovary syndrome |
| topic | anovulation pcos clomiphene citrate tamoxifen metformin letrozole gonadotrophins ovulation induction endometrium |
| url | https://svuijm.journals.ekb.eg/article_356800.html |
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