Multiple gene-deletion vaccinia virus Tiantan strain against mpox

Multiple gene-deletion vaccinia virus Tiantan strain against mpox

Abstract Monkeypox virus (MPXV) is an important zoonotic pathogenic virus, which poses serious threats to public health. MPXV infection can be prevented by immunization against the variola virus. Because of the safety risks and side effects of vaccination with live vaccinia virus (VACV) strain Tian...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yilong Zhu, Dapeng Li, Renshuang Zhao, Minghua Chen, Yue Li, Xia Yang, Hongyue Mao, Xiao Li, Yiquan Li, Chao Shang, Xianzhu Xia
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Series:	Virology Journal
Subjects:	Attenuated vaccinia virus Monkeypox virus Mouse and rabbit models Immunogenicity and protective efficacy
Online Access:	https://doi.org/10.1186/s12985-025-02629-6
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Mutations in the <i>A34R</i> gene increase the immunogenicity of vaccinia virus
by: S. N. Shchelkunov, et al.
Published: (2021-04-01)

A functional approach to analyze the genetic basis for differences in virulence of monkeypox virus clades
by: Patricia L. Earl, et al.
Published: (2025-12-01)

Smallpox vaccination in a mouse model
by: S. N. Shchelkunov, et al.
Published: (2023-11-01)

Geographic Distribution of Vaccinia Virus, Diagnosis and Demographic Aspects of Affected Populations, Minas Gerais, Brazil, 2000–2023
by: Pedro H. B. e Silva, et al.
Published: (2024-12-01)

A model of the artificial metastasis of human epidermoid carcinoma A431 in nude mice for examination of the oncolytic activity of vaccinia virus
by: G. V. Kochneva, et al.
Published: (2015-12-01)

Chemical cross‐linking facilitates antigen uptake and presentation and provides improved protection from Mpox with a dual‐antigen subunit vaccine
by: Long Chen, et al.
Published: (2025-01-01)

Association of HIV infection and hospitalization among mpox cases: a systematic review and meta-analysis
by: Muhammed Shabil, et al.
Published: (2025-01-01)

Specific Immune Responses and Oncolytic Effects Induced by EBV LMP2A-Armed Modified Ankara-Vaccinia Virus Vectored Vaccines in Nasopharyngeal Cancer
by: Liying Sun, et al.
Published: (2025-01-01)

The immunogenicity of PRV ΔgE/TK/UL49.5 three-gene-deleted vaccine in mice
by: Chenmeng Ding, et al.
Published: (2025-02-01)

Single Dose of Attenuated Vaccinia Viruses Expressing H5 Hemagglutinin Affords Rapid and Long-Term Protection Against Lethal Infection with Highly Pathogenic Avian Influenza A H5N1 Virus in Mice and Monkeys
by: Fumihiko Yasui, et al.
Published: (2025-01-01)

Domestic Dogs Exposed to Orthopoxvirus in Urban Areas of Brazil
by: Débora de Meneses, et al.
Published: (2025-01-01)

A novel isothermal whole genome sequencing approach for Monkeypox Virus
by: Matthias Licheri, et al.
Published: (2024-09-01)

Assessing the effect of beta-propiolactone inactivation on the antigenicity and immunogenicity of cluster 2.1 duck Tembusu virus
by: Kanana Rungprasert, et al.
Published: (2025-03-01)

Genome stability of the vaccine strain VAC∆6
by: R. A. Maksyutov, et al.
Published: (2022-07-01)

Optimizing Microneutralization and IFN-γ ELISPOT Assays to Evaluate Mpox Immunity
by: Yinyi Yu, et al.
Published: (2024-12-01)

Characteristics of the monkeypox virus isolate obtained from the first patient in Russia and its sensitivity to 7-[N-(4-trifluoromethylbenzoyl)-hydrazinocarbonyl]-tricyclo-[3.2.2.0^2,4]non-8-en-6-carboxylic acid
by: Alena S. Ovchinnikova, et al.
Published: (2024-12-01)

Novel drug targets for monkeypox: From viral to host proteins
by: Zhaozhong Zhu, et al.
Published: (2025-03-01)

Monkeypox: a re-emergent virus with global health implications – a comprehensive review
by: Nourhan G. Naga, et al.
Published: (2025-01-01)

Comprehensive Insights into Monkeypox (mpox): Recent Advances in Epidemiology, Diagnostic Approaches and Therapeutic Strategies
by: Suresh Kumar, et al.
Published: (2024-12-01)

Optimization of RHDV type 1 and 2 inactivation modes
by: E. D. Kunikova, et al.
Published: (2021-03-01)

Sculpting multi-epitope vaccine against Monkeypox viral strains using immunoinformatics
by: Zaira Rehman, et al.
Published: (2025-01-01)

Expert consensus and recommendations on the live attenuated hepatitis A vaccine and immunization practices in India
by: Nitin Shah, et al.
Published: (2025-12-01)

Assessment of MPOX infection-related knowledge levels, concerns, and associated factors: a community-based cross-sectional study
by: Mehmet Emin Arayici, et al.
Published: (2025-01-01)

Facts about Wildlife Diseases: Rabbit Hemorrhagic Disease Virus Serotype 2 (RHDV2)
by: Catherine E. Dixon, et al.
Published: (2022-04-01)

Persistence of the Immune Response to an Intramuscular Bivalent (GI.1/GII.4) Norovirus Vaccine in Adults
by: Geert Leroux-Roels, et al.
Published: (2025-01-01)

Inactivation of Zika Virus with Hydroxypropyl-Beta-Cyclodextrin
by: Cory R. Hewitt, et al.
Published: (2025-01-01)

Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites
by: Ciying Qian, et al.
Published: (2025-01-01)

The role of new hepatitis B vaccines in South Africa
by: G U van Zyl, et al.
Published: (2024-02-01)

Evaluating passive immunity in piglets from sows vaccinated with a PEDV S protein subunit vaccine
by: Jiajia Liu, et al.
Published: (2025-01-01)

Reactogenicity and Immunogenicity Against MPXV of the Intradermal Administration of Modified Vaccinia Ankara Compared to the Standard Subcutaneous Route
by: Valentina Mazzotta, et al.
Published: (2024-12-01)

Preparation and application evaluation of monoclonal antibodies against Monkeypox virus A29 protein
by: Ai Xiangjun, et al.
Published: (2025-01-01)

The Growing Mpox Infections by Clade I Variant in African Countries Is a Public Health Emergency of International Concern: A Narrative Review
by: Taslima Jamal Urmi, et al.
Published: (2025-01-01)

Investigating the reassortment potential and pathogenicity of the S segment in Akabane virus using a reverse genetics system
by: Eun-Jee Na, et al.
Published: (2025-01-01)

A comparative study of replicative properties of antitumor recombinant vaccinia viruses on human glioblastoma cell culture U87 and monkey kidney cell culture CV-1
by: R. A. Maksyutov, et al.
Published: (2017-02-01)

Serum Mpox-specific IgG titers before and after breakthrough Mpox infection in an HIV-infected individual with viral suppression and prior 2-dose Mpox vaccination
by: Wang-Da Liu, et al.
Published: (2025-02-01)

Development and Evaluation of the Immunogenic Potential of an Unmodified Nucleoside mRNA Vaccine for Herpes Zoster
by: Shun Zhang, et al.
Published: (2025-01-01)

Possibility of using a mouse SCID as a model animal to variola virus for evaluating anti-smallpox drug efficacy
by: K. A. Titova, et al.
Published: (2015-12-01)

An mpox quadrivalent mRNA vaccine elicits sustained and protective immunity in mice against lethal vaccinia virus challenge
by: Entao Li, et al.
Published: (2025-12-01)

Targeted Delivery of Nanovaccine to Dendritic Cells via DC-Binding Peptides Induces Potent Antiviral Immunity in vivo [Expression of Concern]
by: Lu Y, et al.
Published: (2025-01-01)

eEF-2K Deficiency Boosts the Virus-Specific Effector CD8<sup>+</sup> T Cell Responses During Viral Infection
by: Liqing Wang, et al.
Published: (2024-12-01)