Emodin Enhanced Microwave‐Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria‐Infected Osteomyelitis
Abstract Eradication of osteomyelitis caused by bacterial infections is still a major challenge. Microwave therapy has the inherent advantage of deep penetration in curing deep tissue infections. However, the antibacterial efficiency of sensitizers is limited by the weak energy of microwaves. Here,...
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202409979 |
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| author | Tao Xu Hao Cheng Hailiang Pei Jiameng Wang Yiwei Shi Xiangyu Zhang Di Huang |
| author_facet | Tao Xu Hao Cheng Hailiang Pei Jiameng Wang Yiwei Shi Xiangyu Zhang Di Huang |
| author_sort | Tao Xu |
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| description | Abstract Eradication of osteomyelitis caused by bacterial infections is still a major challenge. Microwave therapy has the inherent advantage of deep penetration in curing deep tissue infections. However, the antibacterial efficiency of sensitizers is limited by the weak energy of microwaves. Here, a hybrid heterojunction system (Fe3O4/CuS/Emo) is designed for curing bacterially infected osteomyelitis. As an enhanced microwave sensitizer, it shows supernormal microwave response ability. Specifically, Fe3O4 acts as a matrix to mediate magnetic loss. After CuS loading, the heterogeneous interface forms induce significant interfacial polarization, which increasing dielectric loss. On the basis of the heterojunction formed by the two semiconductors, emodin is innovatively introduced to modify it. This integration not only accelerates the movement of charge carriers but also enhances polarization loss due to the numerous functional groups present on the surface. This further optimizes the microwave thermal and catalytic response. In addition, the unique anti‐inflammatory properties of emodin confer the ability of hybrid heterojunction to regulate the immune microenvironment. In vivo studies reveal that heterojunction modified by emodin programmed elimination of bacteria and regulation of the immune microenvironment. It offers a revolutionary approach to the treatment of bacterial osteomyelitis. |
| format | Article |
| id | doaj-art-3e2ef676fc9945a886579150eaaa66dc |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Advanced Science |
| spelling | doaj-art-3e2ef676fc9945a886579150eaaa66dc2025-01-20T13:04:18ZengWileyAdvanced Science2198-38442025-01-01123n/an/a10.1002/advs.202409979Emodin Enhanced Microwave‐Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria‐Infected OsteomyelitisTao Xu0Hao Cheng1Hailiang Pei2Jiameng Wang3Yiwei Shi4Xiangyu Zhang5Di Huang6Department of Biomedical Engineering Research Center for Nano‐biomaterials & Regenerative Medicine College of Artificial Intelligence Taiyuan University of Technology Taiyuan 030024 ChinaDepartment of Biomedical Engineering Research Center for Nano‐biomaterials & Regenerative Medicine College of Artificial Intelligence Taiyuan University of Technology Taiyuan 030024 ChinaDepartment of Biomedical Engineering Research Center for Nano‐biomaterials & Regenerative Medicine College of Artificial Intelligence Taiyuan University of Technology Taiyuan 030024 ChinaShanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 ChinaNHC Key Laboratory of Pneumoconiosis Department of Pulmonary and Critical Care Medicine First Hospital of Shanxi Medical University Taiyuan 030001 ChinaDepartment of Biomedical Engineering Research Center for Nano‐biomaterials & Regenerative Medicine College of Artificial Intelligence Taiyuan University of Technology Taiyuan 030024 ChinaDepartment of Biomedical Engineering Research Center for Nano‐biomaterials & Regenerative Medicine College of Artificial Intelligence Taiyuan University of Technology Taiyuan 030024 ChinaAbstract Eradication of osteomyelitis caused by bacterial infections is still a major challenge. Microwave therapy has the inherent advantage of deep penetration in curing deep tissue infections. However, the antibacterial efficiency of sensitizers is limited by the weak energy of microwaves. Here, a hybrid heterojunction system (Fe3O4/CuS/Emo) is designed for curing bacterially infected osteomyelitis. As an enhanced microwave sensitizer, it shows supernormal microwave response ability. Specifically, Fe3O4 acts as a matrix to mediate magnetic loss. After CuS loading, the heterogeneous interface forms induce significant interfacial polarization, which increasing dielectric loss. On the basis of the heterojunction formed by the two semiconductors, emodin is innovatively introduced to modify it. This integration not only accelerates the movement of charge carriers but also enhances polarization loss due to the numerous functional groups present on the surface. This further optimizes the microwave thermal and catalytic response. In addition, the unique anti‐inflammatory properties of emodin confer the ability of hybrid heterojunction to regulate the immune microenvironment. In vivo studies reveal that heterojunction modified by emodin programmed elimination of bacteria and regulation of the immune microenvironment. It offers a revolutionary approach to the treatment of bacterial osteomyelitis.https://doi.org/10.1002/advs.202409979antimicrobialdielectric lossesheterogeneous interfacesmicrowave responseosteomyelitis |
| spellingShingle | Tao Xu Hao Cheng Hailiang Pei Jiameng Wang Yiwei Shi Xiangyu Zhang Di Huang Emodin Enhanced Microwave‐Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria‐Infected Osteomyelitis Advanced Science antimicrobial dielectric losses heterogeneous interfaces microwave response osteomyelitis |
| title | Emodin Enhanced Microwave‐Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria‐Infected Osteomyelitis |
| title_full | Emodin Enhanced Microwave‐Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria‐Infected Osteomyelitis |
| title_fullStr | Emodin Enhanced Microwave‐Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria‐Infected Osteomyelitis |
| title_full_unstemmed | Emodin Enhanced Microwave‐Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria‐Infected Osteomyelitis |
| title_short | Emodin Enhanced Microwave‐Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria‐Infected Osteomyelitis |
| title_sort | emodin enhanced microwave responsive heterojunction with powerful bactericidal capacity and immunoregulation for curing bacteria infected osteomyelitis |
| topic | antimicrobial dielectric losses heterogeneous interfaces microwave response osteomyelitis |
| url | https://doi.org/10.1002/advs.202409979 |
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