Peptides developed against receptor binding sites of the E glycoprotein neutralize tick-borne encephalitis virus

Peptides developed against receptor binding sites of the E glycoprotein neutralize tick-borne encephalitis virus

Abstract Infection caused by tick-borne encephalitis virus (TBEV) often manifests with meningitis or encephalitis. Domain III (DIII) of the envelope (E) glycoprotein on the TBEV surface facilitates virion attachment to the cell receptor and initiates cell entry. As a result, this research focused on...

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Main Authors: Patrícia Petroušková, Katarína Bhide, Evelína Mochnáčová, Amod Kulkarni, Jana Jozefiaková, Zuzana Tkáčová, Tomáš Maľarik, Katarína Kucková, Lea Talpašová, Jakub Víglaský, Ádám Kevély, Kamila Koči, Eva Nováková, Juraj Koči, Mangesh Bhide
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Tick-borne encephalitis virus
Domain III
Blocking peptides
Phage display
hBMECs
PRNT
Online Access:https://doi.org/10.1038/s41598-025-95449-1
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