Malignant Peritoneum Mesothelioma with Hepatic Involvement: A Single Institution Experience in 5 Patients and Review of the Literature
Malignant peritoneal mesothelioma with invasion of the liver is an invariably fatal disease. We aimed to clarify the characteristics of malignant peritoneal mesothelioma cases with liver involvement. The clinical presentation, computed tomography images, and immunohistochemical and histopathological...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/6242149 |
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| author | Shan-shan Su Guo-qi Zheng Ya-gang Liu Yue-feng Chen Zhao-wei Song Shu-jing Yu Ning-ning Sun Yu-xin Yang |
| author_facet | Shan-shan Su Guo-qi Zheng Ya-gang Liu Yue-feng Chen Zhao-wei Song Shu-jing Yu Ning-ning Sun Yu-xin Yang |
| author_sort | Shan-shan Su |
| collection | DOAJ |
| description | Malignant peritoneal mesothelioma with invasion of the liver is an invariably fatal disease. We aimed to clarify the characteristics of malignant peritoneal mesothelioma cases with liver involvement. The clinical presentation, computed tomography images, and immunohistochemical and histopathological features of 5 patients with malignant peritoneal mesothelioma and liver involvement were evaluated. The diagnosis was established by imaging and immune profiles of the tumours. A review of 8 cases with primary or invading malignant mesothelioma in liver is presented. All 5 mesothelioma cases were asbestos-related. CT images of malignant peritoneal mesothelioma with the liver involvement typically showed that the lesion grew inside the liver along the capsule and was possibly accompanied by capsule breakthrough and extrahepatic infiltration. The tumours exhibited a common epithelioid appearance in all 5 patients and most cases revealed positive Cal, CK, and MC with negative CEA and HeP. Different from our findings, the review of literature revealed that most malignant mesothelioma of liver was due to primary intrahepatic malignant mesothelioma. Finally, we concluded that the diagnosis of malignant peritoneal mesothelioma cases with liver invasion is reliably achieved by the history of asbestos exposure, the characteristic CT imaging, and immune profiles of the tumours. |
| format | Article |
| id | doaj-art-3e1df3c3e867446db6d31b9dc6389d3b |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-3e1df3c3e867446db6d31b9dc6389d3b2025-02-03T06:01:15ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/62421496242149Malignant Peritoneum Mesothelioma with Hepatic Involvement: A Single Institution Experience in 5 Patients and Review of the LiteratureShan-shan Su0Guo-qi Zheng1Ya-gang Liu2Yue-feng Chen3Zhao-wei Song4Shu-jing Yu5Ning-ning Sun6Yu-xin Yang7Department of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaDepartment of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaDepartment of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaDepartment of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaDepartment of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaDepartment of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaDepartment of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaDepartment of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, ChinaMalignant peritoneal mesothelioma with invasion of the liver is an invariably fatal disease. We aimed to clarify the characteristics of malignant peritoneal mesothelioma cases with liver involvement. The clinical presentation, computed tomography images, and immunohistochemical and histopathological features of 5 patients with malignant peritoneal mesothelioma and liver involvement were evaluated. The diagnosis was established by imaging and immune profiles of the tumours. A review of 8 cases with primary or invading malignant mesothelioma in liver is presented. All 5 mesothelioma cases were asbestos-related. CT images of malignant peritoneal mesothelioma with the liver involvement typically showed that the lesion grew inside the liver along the capsule and was possibly accompanied by capsule breakthrough and extrahepatic infiltration. The tumours exhibited a common epithelioid appearance in all 5 patients and most cases revealed positive Cal, CK, and MC with negative CEA and HeP. Different from our findings, the review of literature revealed that most malignant mesothelioma of liver was due to primary intrahepatic malignant mesothelioma. Finally, we concluded that the diagnosis of malignant peritoneal mesothelioma cases with liver invasion is reliably achieved by the history of asbestos exposure, the characteristic CT imaging, and immune profiles of the tumours.http://dx.doi.org/10.1155/2016/6242149 |
| spellingShingle | Shan-shan Su Guo-qi Zheng Ya-gang Liu Yue-feng Chen Zhao-wei Song Shu-jing Yu Ning-ning Sun Yu-xin Yang Malignant Peritoneum Mesothelioma with Hepatic Involvement: A Single Institution Experience in 5 Patients and Review of the Literature Gastroenterology Research and Practice |
| title | Malignant Peritoneum Mesothelioma with Hepatic Involvement: A Single Institution Experience in 5 Patients and Review of the Literature |
| title_full | Malignant Peritoneum Mesothelioma with Hepatic Involvement: A Single Institution Experience in 5 Patients and Review of the Literature |
| title_fullStr | Malignant Peritoneum Mesothelioma with Hepatic Involvement: A Single Institution Experience in 5 Patients and Review of the Literature |
| title_full_unstemmed | Malignant Peritoneum Mesothelioma with Hepatic Involvement: A Single Institution Experience in 5 Patients and Review of the Literature |
| title_short | Malignant Peritoneum Mesothelioma with Hepatic Involvement: A Single Institution Experience in 5 Patients and Review of the Literature |
| title_sort | malignant peritoneum mesothelioma with hepatic involvement a single institution experience in 5 patients and review of the literature |
| url | http://dx.doi.org/10.1155/2016/6242149 |
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