The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients
Introduction. Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions tha...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2020/8893653 |
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| author | Ade Yonata Zulkhair Ali Taufik Indrajaya Erial Bahar Ian Effendi Novadian Suhaimi Suprapti Suprapti |
| author_facet | Ade Yonata Zulkhair Ali Taufik Indrajaya Erial Bahar Ian Effendi Novadian Suhaimi Suprapti Suprapti |
| author_sort | Ade Yonata |
| collection | DOAJ |
| description | Introduction. Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process. Ultrasound examination of the carotid intima-media thickness (cIMT) is a noninvasive method to assess vascular calcification. This study aimed to analyze the relationship between the activin A serum level and cIMT in patients with CKD at Mohammad Hoesin Hospital, Palembang, Indonesia. Methods. We conducted a hospital-based, cross-sectional study of consecutive CKD patients at the Department of Internal Medicine, Mohammad Hoesin Hospital, from July to November 2019. The level of activin A was measured by enzyme-linked immunosorbent assay. Meanwhile, cIMT measurements were collected by B-mode ultrasound imaging. Results. A total of 55 patients with CKD were included in this investigation. The median serum activin A level in these patients was 236.17 (116.33–283) pg/mL, while the median cIMT was 0.8 (0.6–1.45) mm. A relationship between the serum activin A level and cIMT (r = 0.449; p=0.001) was observed. During multivariate analysis with linear regression, triglyceride p=0.049, phosphate p=0.005, and activin A p=0.020 serum levels were factors associated with cIMT. Conclusion. In this study, a relationship between the activin A serum level and cIMT in patients with CKD was identified. Vascular calcification should be screened for in all CKD patients by the measurement of cIMT. |
| format | Article |
| id | doaj-art-3e18d005f0ee4ca4bf7a18948d7fcb55 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-3e18d005f0ee4ca4bf7a18948d7fcb552025-02-03T01:25:45ZengWileyInternational Journal of Nephrology2090-214X2090-21582020-01-01202010.1155/2020/88936538893653The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease PatientsAde Yonata0Zulkhair Ali1Taufik Indrajaya2Erial Bahar3Ian Effendi4Novadian Suhaimi5Suprapti Suprapti6Department of Internal Medicine, Faculty of Medicine, Lampung University, Bandar Lampung 35141, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Sriwijaya University, Palembang 30126, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Sriwijaya University, Palembang 30126, IndonesiaDepartment of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang 30126, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Sriwijaya University, Palembang 30126, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Sriwijaya University, Palembang 30126, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Sriwijaya University, Palembang 30126, IndonesiaIntroduction. Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process. Ultrasound examination of the carotid intima-media thickness (cIMT) is a noninvasive method to assess vascular calcification. This study aimed to analyze the relationship between the activin A serum level and cIMT in patients with CKD at Mohammad Hoesin Hospital, Palembang, Indonesia. Methods. We conducted a hospital-based, cross-sectional study of consecutive CKD patients at the Department of Internal Medicine, Mohammad Hoesin Hospital, from July to November 2019. The level of activin A was measured by enzyme-linked immunosorbent assay. Meanwhile, cIMT measurements were collected by B-mode ultrasound imaging. Results. A total of 55 patients with CKD were included in this investigation. The median serum activin A level in these patients was 236.17 (116.33–283) pg/mL, while the median cIMT was 0.8 (0.6–1.45) mm. A relationship between the serum activin A level and cIMT (r = 0.449; p=0.001) was observed. During multivariate analysis with linear regression, triglyceride p=0.049, phosphate p=0.005, and activin A p=0.020 serum levels were factors associated with cIMT. Conclusion. In this study, a relationship between the activin A serum level and cIMT in patients with CKD was identified. Vascular calcification should be screened for in all CKD patients by the measurement of cIMT.http://dx.doi.org/10.1155/2020/8893653 |
| spellingShingle | Ade Yonata Zulkhair Ali Taufik Indrajaya Erial Bahar Ian Effendi Novadian Suhaimi Suprapti Suprapti The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients International Journal of Nephrology |
| title | The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients |
| title_full | The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients |
| title_fullStr | The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients |
| title_full_unstemmed | The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients |
| title_short | The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients |
| title_sort | association between the activin a serum level and carotid intima media thickness in chronic kidney disease patients |
| url | http://dx.doi.org/10.1155/2020/8893653 |
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