Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy?
Background. Tenascin-C (TN-C) is an extracellular matrix glycoprotein that appears at sites of inflammation in cardiac pathologies. Aim of the Work. To evaluate the role of TN-C as a marker for active inflammation in children with dilated cardiomyopathy (DCM). Subjects and Methods. 24 consecutive pa...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2013/608563 |
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| author | Alyaa A. Kotby Manal M. Abdel Aziz Waleed M. El Guindy Amira N. Moneer |
| author_facet | Alyaa A. Kotby Manal M. Abdel Aziz Waleed M. El Guindy Amira N. Moneer |
| author_sort | Alyaa A. Kotby |
| collection | DOAJ |
| description | Background. Tenascin-C (TN-C) is an extracellular matrix glycoprotein that appears at sites of inflammation in cardiac pathologies. Aim of the Work. To evaluate the role of TN-C as a marker for active inflammation in children with dilated cardiomyopathy (DCM). Subjects and Methods. 24 consecutive patients with primary nonfamilial DCM aged 6–72 months (mean 45.19±11.03) were divided into group I, twelve patients with acute onset DCM (<6 months duration), and group II, twelve patients with chronic DCM (>6 months duration), and compared to 20 healthy age- and sex-matched controls. Investigations included estimation of serum TN-C and echocardiographic evaluation using M-mode and 2D speckle tracking echocardiography (STE). Results. Serum TN-C showed a higher significant statistical elevation among patients than controls (P<0.001) and in group I than group II (P<0.001). EF was significantly decreased, and LVEDD and EDV increased in patients than controls and in GI than GII. STE showed a statistically significant difference in global peak strain longitudinal (GPSL) average in patients than controls (P<0.05) and between GI and GII (P<0.001). STE wall motion scoring showed normokinesia (33.5%), hypokinesia (8.33%), and akinesia (50%) in GI and hypokinesia (100%) in GII. There was a statistically significant positive correlation between serum TN-C and GPSL average. Conclusions. Increased serum TN-C can be used as a marker of inflammation in DCM and is associated with the severity of heart failure and LV dysfunction as detected by STE. |
| format | Article |
| id | doaj-art-3e1749bc76464a9fb128bec315ff8c0a |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-3e1749bc76464a9fb128bec315ff8c0a2025-02-03T05:59:01ZengWileyInternational Journal of Pediatrics1687-97401687-97592013-01-01201310.1155/2013/608563608563Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy?Alyaa A. Kotby0Manal M. Abdel Aziz1Waleed M. El Guindy2Amira N. Moneer3Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo 11231, EgyptDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, EgyptDepartment of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo 11231, EgyptDepartment of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo 11231, EgyptBackground. Tenascin-C (TN-C) is an extracellular matrix glycoprotein that appears at sites of inflammation in cardiac pathologies. Aim of the Work. To evaluate the role of TN-C as a marker for active inflammation in children with dilated cardiomyopathy (DCM). Subjects and Methods. 24 consecutive patients with primary nonfamilial DCM aged 6–72 months (mean 45.19±11.03) were divided into group I, twelve patients with acute onset DCM (<6 months duration), and group II, twelve patients with chronic DCM (>6 months duration), and compared to 20 healthy age- and sex-matched controls. Investigations included estimation of serum TN-C and echocardiographic evaluation using M-mode and 2D speckle tracking echocardiography (STE). Results. Serum TN-C showed a higher significant statistical elevation among patients than controls (P<0.001) and in group I than group II (P<0.001). EF was significantly decreased, and LVEDD and EDV increased in patients than controls and in GI than GII. STE showed a statistically significant difference in global peak strain longitudinal (GPSL) average in patients than controls (P<0.05) and between GI and GII (P<0.001). STE wall motion scoring showed normokinesia (33.5%), hypokinesia (8.33%), and akinesia (50%) in GI and hypokinesia (100%) in GII. There was a statistically significant positive correlation between serum TN-C and GPSL average. Conclusions. Increased serum TN-C can be used as a marker of inflammation in DCM and is associated with the severity of heart failure and LV dysfunction as detected by STE.http://dx.doi.org/10.1155/2013/608563 |
| spellingShingle | Alyaa A. Kotby Manal M. Abdel Aziz Waleed M. El Guindy Amira N. Moneer Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy? International Journal of Pediatrics |
| title | Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy? |
| title_full | Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy? |
| title_fullStr | Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy? |
| title_full_unstemmed | Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy? |
| title_short | Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy? |
| title_sort | can serum tenascin c be used as a marker of inflammation in patients with dilated cardiomyopathy |
| url | http://dx.doi.org/10.1155/2013/608563 |
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