Metronidazole and Vancomycin Have a Synergic Effect, with Plant Extracts as Helpful Tools to Combat <i>Clostridioides difficile</i> Infections
<b>Background/Objectives:</b> The prolonged use of antibiotics is closely related to increased infections caused by <i>Clostridioides difficile</i> (Cdiff). Plant-origin compounds have been expanding in recent years as the best opportunity to identify new synergic therapies t...
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MDPI AG
2025-01-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/1/54 |
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| author | Nancy C. Ruiz-Pérez Yuli Bayona-Pérez Silvia Laura Guzmán-Gutiérrez Ricardo Reyes-Chilpa Víctor M. Luna-Pineda Javier Torres Mariana Romo-Castillo |
| author_facet | Nancy C. Ruiz-Pérez Yuli Bayona-Pérez Silvia Laura Guzmán-Gutiérrez Ricardo Reyes-Chilpa Víctor M. Luna-Pineda Javier Torres Mariana Romo-Castillo |
| author_sort | Nancy C. Ruiz-Pérez |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> The prolonged use of antibiotics is closely related to increased infections caused by <i>Clostridioides difficile</i> (Cdiff). Plant-origin compounds have been expanding in recent years as the best opportunity to identify new synergic therapies to combat antibiotic-associated diseases. Mexico has incredible plant biodiversity; natural compounds with antibacterial properties are an alternative treatment. The main objective of this study was to analyze the effect of medicinal plants with an antibacterial action against toxigenic clinical Cdiff strains that have a synergic effect on the antibiotics commonly used to combat this disease. <b>Methods:</b> The plants were selected for plants that were previously used in research, and their extracts were tested against Cdiff strains. The antibacterial activity, synergy, and antagonism between the extracts and their synergic effect with antibiotics were evaluated. <b>Results:</b> Our results demonstrated that some extracts have effective antimicrobial activity and synergic effects with vancomycin and metronidazole. <b>Conclusions:</b> This study suggests that plant extracts and plant compounds derived from these extracts could be used as synergic-antibiotic therapy to combat Cdiff infections. |
| format | Article |
| id | doaj-art-3e12026bb0fc4c5987ca9ff9a711e489 |
| institution | Kabale University |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-3e12026bb0fc4c5987ca9ff9a711e4892025-01-24T13:18:45ZengMDPI AGAntibiotics2079-63822025-01-011415410.3390/antibiotics14010054Metronidazole and Vancomycin Have a Synergic Effect, with Plant Extracts as Helpful Tools to Combat <i>Clostridioides difficile</i> InfectionsNancy C. Ruiz-Pérez0Yuli Bayona-Pérez1Silvia Laura Guzmán-Gutiérrez2Ricardo Reyes-Chilpa3Víctor M. Luna-Pineda4Javier Torres5Mariana Romo-Castillo6División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa 86025, MexicoDivisión Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa 86025, MexicoColegio de Ciencias y Humanidades, Casa Libertad, Universidad Autónoma de la Ciudad de México, Mexico City 09620, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoLaboratorio de Investigación en Patógenos Respiratorios y Producción de Biológicos, Hospital Infantil de México Federico Gómez, Mexico City 06720, MexicoUnidad de Investigación Médica en EnfermedadesInfecciosas y Parasitarias, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, Mexico City 06720, MexicoInvestigadora e Investigadores por México, Consejo Nacional de Humanidades, Ciencia y Tecnología, Mexico City 03940, Mexico<b>Background/Objectives:</b> The prolonged use of antibiotics is closely related to increased infections caused by <i>Clostridioides difficile</i> (Cdiff). Plant-origin compounds have been expanding in recent years as the best opportunity to identify new synergic therapies to combat antibiotic-associated diseases. Mexico has incredible plant biodiversity; natural compounds with antibacterial properties are an alternative treatment. The main objective of this study was to analyze the effect of medicinal plants with an antibacterial action against toxigenic clinical Cdiff strains that have a synergic effect on the antibiotics commonly used to combat this disease. <b>Methods:</b> The plants were selected for plants that were previously used in research, and their extracts were tested against Cdiff strains. The antibacterial activity, synergy, and antagonism between the extracts and their synergic effect with antibiotics were evaluated. <b>Results:</b> Our results demonstrated that some extracts have effective antimicrobial activity and synergic effects with vancomycin and metronidazole. <b>Conclusions:</b> This study suggests that plant extracts and plant compounds derived from these extracts could be used as synergic-antibiotic therapy to combat Cdiff infections.https://www.mdpi.com/2079-6382/14/1/54<i>Clostridioides difficile</i> infectionmetronidazolevancomycinplant extractsynergic therapyantibiotic |
| spellingShingle | Nancy C. Ruiz-Pérez Yuli Bayona-Pérez Silvia Laura Guzmán-Gutiérrez Ricardo Reyes-Chilpa Víctor M. Luna-Pineda Javier Torres Mariana Romo-Castillo Metronidazole and Vancomycin Have a Synergic Effect, with Plant Extracts as Helpful Tools to Combat <i>Clostridioides difficile</i> Infections Antibiotics <i>Clostridioides difficile</i> infection metronidazole vancomycin plant extract synergic therapy antibiotic |
| title | Metronidazole and Vancomycin Have a Synergic Effect, with Plant Extracts as Helpful Tools to Combat <i>Clostridioides difficile</i> Infections |
| title_full | Metronidazole and Vancomycin Have a Synergic Effect, with Plant Extracts as Helpful Tools to Combat <i>Clostridioides difficile</i> Infections |
| title_fullStr | Metronidazole and Vancomycin Have a Synergic Effect, with Plant Extracts as Helpful Tools to Combat <i>Clostridioides difficile</i> Infections |
| title_full_unstemmed | Metronidazole and Vancomycin Have a Synergic Effect, with Plant Extracts as Helpful Tools to Combat <i>Clostridioides difficile</i> Infections |
| title_short | Metronidazole and Vancomycin Have a Synergic Effect, with Plant Extracts as Helpful Tools to Combat <i>Clostridioides difficile</i> Infections |
| title_sort | metronidazole and vancomycin have a synergic effect with plant extracts as helpful tools to combat i clostridioides difficile i infections |
| topic | <i>Clostridioides difficile</i> infection metronidazole vancomycin plant extract synergic therapy antibiotic |
| url | https://www.mdpi.com/2079-6382/14/1/54 |
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