Effect of <i>FABP4</i> Gene Polymorphisms on Fatty Acid Composition, Chemical Composition, and Carcass Traits in Sonid Sheep
Fatty acids (FAs) are a group of organic compounds that are regulated by polygenic and environmental factors and affect the taste, nutritional value, and quality of meat. Lamb meat is rich in FAs required by the human body, which has directed more attention to sheep research and meat production. The...
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2025-01-01
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| author | Jiada Xiang Haofan Li Zhaoxin Guo Terigele Li Takahisa Yamada Xihe Li Siqin Bao Lai Da Gerelt Borjigin Ming Cang Bin Tong |
| author_facet | Jiada Xiang Haofan Li Zhaoxin Guo Terigele Li Takahisa Yamada Xihe Li Siqin Bao Lai Da Gerelt Borjigin Ming Cang Bin Tong |
| author_sort | Jiada Xiang |
| collection | DOAJ |
| description | Fatty acids (FAs) are a group of organic compounds that are regulated by polygenic and environmental factors and affect the taste, nutritional value, and quality of meat. Lamb meat is rich in FAs required by the human body, which has directed more attention to sheep research and meat production. The fatty acid-binding protein 4 (<i>FABP4</i>) gene is considered a candidate gene that can affect FA composition in livestock. Therefore, the aim of this study was to screen for genetic polymorphisms of <i>FABP4</i> and confirm the association between these polymorphisms and FAs, chemical composition, and carcass traits in Sonid lambs. The results of the association study showed that g.57764667T>C, g.57764436T>G, g.57764242G>A, and g.57757988A>G were associated with the composition of certain long-chain FAs, and g.57764242G>A, g.57764436T>G, and g.57758026G>A were associated with free amino acid levels. In addition, g.57764667T>C and g.57757988A>G were associated with carcass weight and live weight in Sonid lambs. Therefore, the polymorphisms of the <i>FABP4</i> gene are expected to be a genetic selection marker for superior traits in Sonid sheep breeding, which also provides new insights into how the ovine <i>FABP4</i> gene affects traits of lamb quality. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-3e0ef9128f1b45fa925f4f32ab227b452025-01-24T13:18:10ZengMDPI AGAnimals2076-26152025-01-0115222610.3390/ani15020226Effect of <i>FABP4</i> Gene Polymorphisms on Fatty Acid Composition, Chemical Composition, and Carcass Traits in Sonid SheepJiada Xiang0Haofan Li1Zhaoxin Guo2Terigele Li3Takahisa Yamada4Xihe Li5Siqin Bao6Lai Da7Gerelt Borjigin8Ming Cang9Bin Tong10The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, ChinaThe State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, ChinaThe State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, ChinaInner Mongolia Agriculture Animal Husbandry Fishery and Biology Experiment Research Centre, Inner Mongolia Agricultural University, Hohhot 010010, ChinaDepartment of Agrobiology, Faculty of Agriculture, Niigata University, Niigata 950-2181, JapanThe State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, ChinaThe State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, ChinaInstitute of Animal Science, Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, ChinaCollege of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010010, ChinaThe State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, ChinaThe State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, ChinaFatty acids (FAs) are a group of organic compounds that are regulated by polygenic and environmental factors and affect the taste, nutritional value, and quality of meat. Lamb meat is rich in FAs required by the human body, which has directed more attention to sheep research and meat production. The fatty acid-binding protein 4 (<i>FABP4</i>) gene is considered a candidate gene that can affect FA composition in livestock. Therefore, the aim of this study was to screen for genetic polymorphisms of <i>FABP4</i> and confirm the association between these polymorphisms and FAs, chemical composition, and carcass traits in Sonid lambs. The results of the association study showed that g.57764667T>C, g.57764436T>G, g.57764242G>A, and g.57757988A>G were associated with the composition of certain long-chain FAs, and g.57764242G>A, g.57764436T>G, and g.57758026G>A were associated with free amino acid levels. In addition, g.57764667T>C and g.57757988A>G were associated with carcass weight and live weight in Sonid lambs. Therefore, the polymorphisms of the <i>FABP4</i> gene are expected to be a genetic selection marker for superior traits in Sonid sheep breeding, which also provides new insights into how the ovine <i>FABP4</i> gene affects traits of lamb quality.https://www.mdpi.com/2076-2615/15/2/226association<i>FABP4</i> genefatty acidsgenetic variantsSonid sheep |
| spellingShingle | Jiada Xiang Haofan Li Zhaoxin Guo Terigele Li Takahisa Yamada Xihe Li Siqin Bao Lai Da Gerelt Borjigin Ming Cang Bin Tong Effect of <i>FABP4</i> Gene Polymorphisms on Fatty Acid Composition, Chemical Composition, and Carcass Traits in Sonid Sheep Animals association <i>FABP4</i> gene fatty acids genetic variants Sonid sheep |
| title | Effect of <i>FABP4</i> Gene Polymorphisms on Fatty Acid Composition, Chemical Composition, and Carcass Traits in Sonid Sheep |
| title_full | Effect of <i>FABP4</i> Gene Polymorphisms on Fatty Acid Composition, Chemical Composition, and Carcass Traits in Sonid Sheep |
| title_fullStr | Effect of <i>FABP4</i> Gene Polymorphisms on Fatty Acid Composition, Chemical Composition, and Carcass Traits in Sonid Sheep |
| title_full_unstemmed | Effect of <i>FABP4</i> Gene Polymorphisms on Fatty Acid Composition, Chemical Composition, and Carcass Traits in Sonid Sheep |
| title_short | Effect of <i>FABP4</i> Gene Polymorphisms on Fatty Acid Composition, Chemical Composition, and Carcass Traits in Sonid Sheep |
| title_sort | effect of i fabp4 i gene polymorphisms on fatty acid composition chemical composition and carcass traits in sonid sheep |
| topic | association <i>FABP4</i> gene fatty acids genetic variants Sonid sheep |
| url | https://www.mdpi.com/2076-2615/15/2/226 |
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