Risk factors for non-responsiveness to 5-aminosalicylic acid in patients with ulcerative colitis identified using retrospective clinical study and Mendelian randomization

Risk factors for non-responsiveness to 5-aminosalicylic acid in patients with ulcerative colitis identified using retrospective clinical study and Mendelian randomization

Abstract This study aimed to identify risk factors and potential targets associated with non-responsiveness to 5-Aminosalicylic acid (5-ASA) in patients with ulcerative colitis (UC). Patients with mild to moderate UC were grouped based on their responsiveness to 5-ASA. Regression analysis was conduc...

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Bibliographic Details
Main Authors: Zhi-Ning Ye, Xin-Tian Liu, Yue-Ming Gu, Shu-Xian Mao, Dan-Hong Liang, Kai Zhan, Hao-Qiang Lei, Shao-Gang Huang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Ulcerative colitis
5-Aminosalicylic acid
Responsiveness
Allergy
Aspartate aminotransferase-to-alanine aminotransferase ratio
Inhibitor of nuclear factor kappa-B kinase subunit alpha
Online Access:https://doi.org/10.1038/s41598-025-89620-x
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https://doi.org/10.1038/s41598-025-89620-x

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