Motif-guided identification of KRAS-interacting proteins

Abstract Background For decades, KRAS has always been a huge challenge to the field of drug discovery for its significance in cancer progression as well as its difficulties in being targeted as an “undruggable” protein. KRAS regulates downstream signaling pathways through protein–protein interaction...

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Bibliographic Details
Main Authors: Sanan Wu, Xiaoyang Gao, Di Wu, Lu Liu, Han Yao, Xiangjun Meng, Xianglei Zhang, Fang Bai
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Biology
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Online Access:https://doi.org/10.1186/s12915-024-02067-w
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