A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects
Rose hip powder (RHP) alleviates osteoarthritis (OA) due to its anti-inflammatory and cartilage-protective properties. Substances contained in RHP might contribute to its clinical efficacy. The activity of two RHP (i.e., RH-A, from the whole fruit, RH-B, from fruits without seeds) was investigated i...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/105710 |
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| author | Joseph Schwager Nathalie Richard Rotraut Schoop Swen Wolfram |
| author_facet | Joseph Schwager Nathalie Richard Rotraut Schoop Swen Wolfram |
| author_sort | Joseph Schwager |
| collection | DOAJ |
| description | Rose hip powder (RHP) alleviates osteoarthritis (OA) due to its anti-inflammatory and cartilage-protective properties. Substances contained in RHP might contribute to its clinical efficacy. The activity of two RHP (i.e., RH-A, from the whole fruit, RH-B, from fruits without seeds) was investigated in human peripheral blood leukocytes (PBL) and primary chondrocytes (NHAC-kn). RH-A and RH-B diminished the secretion of chemokines and cytokines in LPS/IFN-γ-activated PBL, including CCL5/RANTES, CXCL10/IP-10, interleukin- (IL-) 6, and IL-12. Most effects were transcriptional, since gene expression levels were significantly influenced by RH-A and RH-B. In IL-1β treated normal chondrocytes (NHAC-kn), both RH preparations reduced the expression of matrix metalloproteinase- (MMP-) 1, MMP-3, and MMP-13 and ADAMTS-4. These changes are associated with diminished inflammatory damage or cartilage erosion. Principal component analysis revealed that (1) RH-A and RH-B modified a large pattern of biomarkers, and (2) RH-B outperformed RH-A. Furthermore, RH-B contained more chondroprotective and anti-inflammatory constituents than RH-A. Thus, RHP contributed to restore cellular homeostasis in PBL and chondrocytes. RH preparations from fruits without seeds are thus expected to have an improved OA-preventive or OA-therapeutic profile, as subsequently shown in a related clinical trial. |
| format | Article |
| id | doaj-art-3e031ecc47d348e49ea981675d3fa06e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3e031ecc47d348e49ea981675d3fa06e2025-02-03T05:50:43ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/105710105710A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective EffectsJoseph Schwager0Nathalie Richard1Rotraut Schoop2Swen Wolfram3DSM Nutritional Products Ltd., Department of Human Nutrition & Health, P.O. Box 2676, 4002 Basel, SwitzerlandDSM Nutritional Products Ltd., Department of Human Nutrition & Health, P.O. Box 2676, 4002 Basel, SwitzerlandDSM Nutritional Products Ltd., Department of Human Nutrition & Health, P.O. Box 2676, 4002 Basel, SwitzerlandDSM Nutritional Products Ltd., Department of Human Nutrition & Health, P.O. Box 2676, 4002 Basel, SwitzerlandRose hip powder (RHP) alleviates osteoarthritis (OA) due to its anti-inflammatory and cartilage-protective properties. Substances contained in RHP might contribute to its clinical efficacy. The activity of two RHP (i.e., RH-A, from the whole fruit, RH-B, from fruits without seeds) was investigated in human peripheral blood leukocytes (PBL) and primary chondrocytes (NHAC-kn). RH-A and RH-B diminished the secretion of chemokines and cytokines in LPS/IFN-γ-activated PBL, including CCL5/RANTES, CXCL10/IP-10, interleukin- (IL-) 6, and IL-12. Most effects were transcriptional, since gene expression levels were significantly influenced by RH-A and RH-B. In IL-1β treated normal chondrocytes (NHAC-kn), both RH preparations reduced the expression of matrix metalloproteinase- (MMP-) 1, MMP-3, and MMP-13 and ADAMTS-4. These changes are associated with diminished inflammatory damage or cartilage erosion. Principal component analysis revealed that (1) RH-A and RH-B modified a large pattern of biomarkers, and (2) RH-B outperformed RH-A. Furthermore, RH-B contained more chondroprotective and anti-inflammatory constituents than RH-A. Thus, RHP contributed to restore cellular homeostasis in PBL and chondrocytes. RH preparations from fruits without seeds are thus expected to have an improved OA-preventive or OA-therapeutic profile, as subsequently shown in a related clinical trial.http://dx.doi.org/10.1155/2014/105710 |
| spellingShingle | Joseph Schwager Nathalie Richard Rotraut Schoop Swen Wolfram A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects Mediators of Inflammation |
| title | A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects |
| title_full | A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects |
| title_fullStr | A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects |
| title_full_unstemmed | A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects |
| title_short | A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects |
| title_sort | novel rose hip preparation with enhanced anti inflammatory and chondroprotective effects |
| url | http://dx.doi.org/10.1155/2014/105710 |
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