Elevated albumin: a protective factor against mortality in geriatric hip fracture patients
Abstract Introduction To evaluate the association between albumin concentration at admission and mortality in elderly patients with hip fractures. Methods Elderly patients with hip fractures were screened between Jan 2015 and Sep 2019. Demographic and clinical characteristics of the patients were co...
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BMC
2025-05-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-025-05873-2 |
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| author | Hai Huang Yao Liu Bin-Fei Zhang |
| author_facet | Hai Huang Yao Liu Bin-Fei Zhang |
| author_sort | Hai Huang |
| collection | DOAJ |
| description | Abstract Introduction To evaluate the association between albumin concentration at admission and mortality in elderly patients with hip fractures. Methods Elderly patients with hip fractures were screened between Jan 2015 and Sep 2019. Demographic and clinical characteristics of the patients were collected. Linear and nonlinear multivariate Cox regression models were used to identify the association between albumin concentration at admission and mortality. All analyses were performed using EmpowerStats and the R software. Results This retrospective cohort study included 2387 patients who met the study criteria. The mean follow-up was 37.64 months. The albumin concentration was 37.72 ± 4.03 g/L. Multivariate Cox regression showed that albumin concentration was associated with mortality in geriatric patients with hip fracture (Hazard Ratio [HR] = 0.94, 95% confidence intervals [CI]:0.92–0.96, P < 0.0001). Compared to the low albumin group (< 35 g/L), the medium group (≥ 35 g/L and < 40 g/L) decreased mortality risk by 29% (HR = 0.71, 95%CI:0.59–0.86, P = 0.0003), and the high group (≥ 40 g/L) decreased mortality risk by 38% (HR = 0.62, 95%CI:0.49–0.79, P < 0.0001). In addition, the test for a linear trend (P for trend) also showed a linear correlation in the different models. No saturation or threshold effect was observed in the nonlinear association. The sensitivity analysis used propensity score matching, and the results were stable. Conclusion The albumin concentrations at admission were associated with mortality in geriatric hip fractures, and it could be considered a predictor for the risk of mortality. (ChiCTR2200057323) |
| format | Article |
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| institution | OA Journals |
| issn | 1749-799X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
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| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-3dfc7bbc5f0147bbbc8e699fa9caa74d2025-08-20T01:53:25ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2025-05-0120111510.1186/s13018-025-05873-2Elevated albumin: a protective factor against mortality in geriatric hip fracture patientsHai Huang0Yao Liu1Bin-Fei Zhang2Department of Trauma Orthopaedic, Honghui Hospital, Xi’an Jiaotong UniversityDepartment of Anesthesiology, Honghui Hospital, Xi’an Jiaotong UniversityDepartment of Joint Surgery, Honghui Hospital, Xi’an Jiaotong UniversityAbstract Introduction To evaluate the association between albumin concentration at admission and mortality in elderly patients with hip fractures. Methods Elderly patients with hip fractures were screened between Jan 2015 and Sep 2019. Demographic and clinical characteristics of the patients were collected. Linear and nonlinear multivariate Cox regression models were used to identify the association between albumin concentration at admission and mortality. All analyses were performed using EmpowerStats and the R software. Results This retrospective cohort study included 2387 patients who met the study criteria. The mean follow-up was 37.64 months. The albumin concentration was 37.72 ± 4.03 g/L. Multivariate Cox regression showed that albumin concentration was associated with mortality in geriatric patients with hip fracture (Hazard Ratio [HR] = 0.94, 95% confidence intervals [CI]:0.92–0.96, P < 0.0001). Compared to the low albumin group (< 35 g/L), the medium group (≥ 35 g/L and < 40 g/L) decreased mortality risk by 29% (HR = 0.71, 95%CI:0.59–0.86, P = 0.0003), and the high group (≥ 40 g/L) decreased mortality risk by 38% (HR = 0.62, 95%CI:0.49–0.79, P < 0.0001). In addition, the test for a linear trend (P for trend) also showed a linear correlation in the different models. No saturation or threshold effect was observed in the nonlinear association. The sensitivity analysis used propensity score matching, and the results were stable. Conclusion The albumin concentrations at admission were associated with mortality in geriatric hip fractures, and it could be considered a predictor for the risk of mortality. (ChiCTR2200057323)https://doi.org/10.1186/s13018-025-05873-2Albumin concentrationMortalityElderly patientsHip fractureCox regression |
| spellingShingle | Hai Huang Yao Liu Bin-Fei Zhang Elevated albumin: a protective factor against mortality in geriatric hip fracture patients Journal of Orthopaedic Surgery and Research Albumin concentration Mortality Elderly patients Hip fracture Cox regression |
| title | Elevated albumin: a protective factor against mortality in geriatric hip fracture patients |
| title_full | Elevated albumin: a protective factor against mortality in geriatric hip fracture patients |
| title_fullStr | Elevated albumin: a protective factor against mortality in geriatric hip fracture patients |
| title_full_unstemmed | Elevated albumin: a protective factor against mortality in geriatric hip fracture patients |
| title_short | Elevated albumin: a protective factor against mortality in geriatric hip fracture patients |
| title_sort | elevated albumin a protective factor against mortality in geriatric hip fracture patients |
| topic | Albumin concentration Mortality Elderly patients Hip fracture Cox regression |
| url | https://doi.org/10.1186/s13018-025-05873-2 |
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