Activation of PPAR𝛾 by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats
Peroxisome proliferator-activated receptor gamma (PPAR𝛾) activation decreased serum testosterone (T) in women with hyperthecosis and/or polycystic ovary syndrome and reduced the conversion of androgens to estradiol (E2) in female rats. This implies modulation of female sex steroid hormones by PPAR𝛾....
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2009/101857 |
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| Summary: | Peroxisome proliferator-activated receptor gamma (PPAR𝛾) activation decreased serum testosterone (T) in women with hyperthecosis and/or polycystic ovary syndrome and reduced the conversion of androgens to estradiol (E2) in female rats. This implies modulation of female sex steroid hormones by PPAR𝛾. It is not clear if PPAR𝛾 modulates sex steroid hormones in diabetic males. Because PPAR𝛾 activation by thiazolidinedione increased insulin sensitivity in type 2 diabetes, understanding the long term impact of PPAR𝛾 activation on steroid sex hormones in males is critical. Our objective was to determine the effect of PPAR𝛾 activation on serum and intratesticular T, luteinizing hormone (LH), follicle stimulating hormone (FSH) and E2 concentrations in male Zucker diabetic fatty (ZDF) rats treated with the PPAR𝛾 agonist rosiglitazone (a thiazolidinedione). Treatment for eight weeks increased PPAR𝛾 mRNA and protein in the testis and elevated serum adiponectin, an adipokine marker for PPAR𝛾 activation. PPAR𝛾 activation did not alter serum or intratesticular T concentrations. In contrast, serum T level but not intratesticular T was reduced by diabetes. Neither diabetes nor PPAR𝛾 activation altered serum E2 or gonadotropins FSH and LH concentrations. The results suggest that activation of PPAR𝛾 by rosiglitazone has no negative impact on sex hormones in male ZDF rats. |
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| ISSN: | 1687-4757 1687-4765 |