The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999–2018
Background Renal impairment has been previously linked to peripheral eosinophil count (PEC), prompting an investigation into its potential relationship with chronic kidney disease (CKD). This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES 1999–2...
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2319324 |
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| author | Shisheng Han Meng Jia Wenli Yuan Yi Wang Yan Lu Yanqiu Xu Li Shang |
| author_facet | Shisheng Han Meng Jia Wenli Yuan Yi Wang Yan Lu Yanqiu Xu Li Shang |
| author_sort | Shisheng Han |
| collection | DOAJ |
| description | Background Renal impairment has been previously linked to peripheral eosinophil count (PEC), prompting an investigation into its potential relationship with chronic kidney disease (CKD). This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES 1999–2018) to comprehensively explore the association between PEC and CKD.Methods Survey-weighted generalized multivariate linear regression was employed to evaluate the associations between PEC, urinary albumin-to-creatinine ratio (UACR), and estimated glomerular filtration rate (eGFR), with meticulous adjustment for potential covariates. To assess non-linear correlations, a restricted cubic spline analysis was conducted. Sensitivity analysis was performed to test the stability of results.Results The study included a total of 9224 participants with non-dialysis CKD. In the multivariate linear regression model, after comprehensive adjustment for potential covariates, PEC showed a negative association with eGFR (β per 100 cells/uL increase in PEC, −0.71; 95% CI, −1.04, −0.37), while demonstrating a positive trend with UACR (β per 100 cells/uL increase in PEC, 10.21; 95% CI, 1.37, 19.06). The restrictive cubic spline curve analysis suggested that these associations occurred within the range of 0 to 400 cells/uL for PEC. Sensitivity analysis supported the stability of the observed results.Conclusions Circulating eosinophil levels are negatively correlated with eGFR and demonstrate a positive trend with UACR, when PEC falls within the range of less than 400 cells/uL among adults with CKD. Further research is warranted to validate these findings. |
| format | Article |
| id | doaj-art-3def932cae304ec182641400a353c3e2 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | Renal Failure |
| spelling | doaj-art-3def932cae304ec182641400a353c3e22025-01-23T04:17:47ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2319324The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999–2018Shisheng Han0Meng Jia1Wenli Yuan2Yi Wang3Yan Lu4Yanqiu Xu5Li Shang6Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Science, Technology and Humanities, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaBackground Renal impairment has been previously linked to peripheral eosinophil count (PEC), prompting an investigation into its potential relationship with chronic kidney disease (CKD). This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES 1999–2018) to comprehensively explore the association between PEC and CKD.Methods Survey-weighted generalized multivariate linear regression was employed to evaluate the associations between PEC, urinary albumin-to-creatinine ratio (UACR), and estimated glomerular filtration rate (eGFR), with meticulous adjustment for potential covariates. To assess non-linear correlations, a restricted cubic spline analysis was conducted. Sensitivity analysis was performed to test the stability of results.Results The study included a total of 9224 participants with non-dialysis CKD. In the multivariate linear regression model, after comprehensive adjustment for potential covariates, PEC showed a negative association with eGFR (β per 100 cells/uL increase in PEC, −0.71; 95% CI, −1.04, −0.37), while demonstrating a positive trend with UACR (β per 100 cells/uL increase in PEC, 10.21; 95% CI, 1.37, 19.06). The restrictive cubic spline curve analysis suggested that these associations occurred within the range of 0 to 400 cells/uL for PEC. Sensitivity analysis supported the stability of the observed results.Conclusions Circulating eosinophil levels are negatively correlated with eGFR and demonstrate a positive trend with UACR, when PEC falls within the range of less than 400 cells/uL among adults with CKD. Further research is warranted to validate these findings.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2319324Eosinophilschronic kidney diseasealbuminuriaNHANEScross-sectional study |
| spellingShingle | Shisheng Han Meng Jia Wenli Yuan Yi Wang Yan Lu Yanqiu Xu Li Shang The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999–2018 Renal Failure Eosinophils chronic kidney disease albuminuria NHANES cross-sectional study |
| title | The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999–2018 |
| title_full | The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999–2018 |
| title_fullStr | The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999–2018 |
| title_full_unstemmed | The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999–2018 |
| title_short | The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999–2018 |
| title_sort | association between peripheral eosinophil count and chronic kidney disease evidence from nhanes 1999 2018 |
| topic | Eosinophils chronic kidney disease albuminuria NHANES cross-sectional study |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2319324 |
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