Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS)

Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS)

Background Inflammation and blood-brain barrier disruption may contribute to the pathogenesis of ischaemic stroke. Minocycline was shown to exert anti-inflammatory effects by attenuating microglial activation and protecting blood-brain barrier in preclinical studies. Previous small-scale clinical st...

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Main Authors: Liping Liu, Yongjun Wang, Yilong Wang, Xingquan Zhao, Yao Lu, Philip M Bath, Xiaoling Liao, Yuesong Pan, S Claiborne Johnston, Pierre Amarenco, Ling Guan, Hui Qu, Luyan Wang, Yicong Wang, Meiyang Zhang, Qianqian Yang, Baoshan Qiu, Dongyang Zhou, Xuejiao Zhou
Format: Article
Language:English
Published: BMJ Publishing Group
Series:Stroke and Vascular Neurology
Online Access:https://svn.bmj.com/content/early/2025/03/26/svn-2024-003577.full
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