Macrophage pyroptosis in atherosclerosis: therapeutic potential

Macrophage pyroptosis in atherosclerosis: therapeutic potential

Atherosclerosis (AS) is a chronic inflammatory disease characterized by the accumulation of lipid-rich plaques in arterial walls, leading to cardiovascular events such as myocardial infarction and stroke. Macrophage pyroptosis, a form of programmed cell death driven by the NLRP3 inflammasome and cas...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ma Jianying, Wang Yixian, Xu Wenna, Wang Hanjing, Wan Zhengdong, Guo Jiawei
Format:	Article
Language:	English
Published:	China Science Publishing & Media Ltd. 2025-02-01
Series:	Acta Biochimica et Biophysica Sinica
Subjects:	atherosclerosis macrophage pyroptosis
Online Access:	https://www.sciengine.com/doi/10.3724/abbs.2025004
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Clusterin ameliorates diabetic atherosclerosis by suppressing macrophage pyroptosis and activation
by: Lingling Xuan, et al.
Published: (2025-04-01)

Atractylenolide I Inhibits Nicotine-Induced Macrophage Pyroptosis and Alleviates Atherogenesis by Suppressing the TLR4/ROS/TXNIP/NLRP3 Pathway
by: Huan-Huan Li, et al.
Published: (2025-05-01)

The novel GSDMD inhibitor GI‐Y2 exerts antipyroptotic effects to reduce atherosclerosis
by: Xiaoxi Fan, et al.
Published: (2025-03-01)

Shared pyroptosis pathways and crosstalk genes underpin inflammatory links between periodontitis and atherosclerosis
by: Pinxin Zhan, et al.
Published: (2025-03-01)

DENV-1 Infection of Macrophages Induces Pyroptosis and Causes Changes in MicroRNA Expression Profiles
by: Qinyi Zhang, et al.
Published: (2024-11-01)

Gut microbial Nordihydroguaiaretic acid suppresses macrophage pyroptosis to regulate epithelial homeostasis and inflammation
by: Jun Wang, et al.
Published: (2025-12-01)

Differences in macrophage pyroptosis and polarization induced by nano-/micro-calcium oxalate crystals
by: Xin-Yi Tong, et al.
Published: (2025-07-01)

FSCN1 is a Potential Therapeutic Target for Atherosclerosis Revealed by Single-Cell and Bulk RNA Sequencing
by: Zhang L, et al.
Published: (2024-11-01)

Dexmedetomidine Mitigates Acute Lung Injury by Enhancing M2 Macrophage Polarization and Inhibiting RAGE/Caspase-11-Mediated Pyroptosis
by: Yisi Zhao, et al.
Published: (2024-12-01)

Identification of pyroptosis related genes and subtypes in atherosclerosis using multiomic and single cell analysis
by: Kaisheng Jiang, et al.
Published: (2025-07-01)

LPS-induced extracellular AREG triggers macrophage pyroptosis through the EGFR/TLR4 signaling pathway
by: Gang Yuan, et al.
Published: (2025-04-01)

Cyclodextrin attenuates atherosclerosis by diminishing gasdermin D (GSDMD)-mediated pyroptosis
by: Mohammad Ismail Hajary Sagor, et al.
Published: (2025-07-01)

Macrophage pyroptosis mediates hyperoxia-induced inflammatory lung injury in neonates
by: Zikun Tu, et al.
Published: (2025-05-01)

Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque
by: Yuwu Chen, et al.
Published: (2025-03-01)

Scutellarin mitigates high glucose-induced pyroptosis in diabetic atherosclerosis: Role of Nrf2-FBXL2-mediated NLRP3 degradation
by: Qingxin Meng, et al.
Published: (2025-05-01)

Peptide-modified mesoporous silica nanoparticles for the coordinated regulation of macrophage polarization and pyroptosis in the treatment of implant-related infections
by: Zhi Li, et al.
Published: (2025-04-01)

Citrulline inhibits LPS‐induced pyroptosis of RAW264.7 macrophages through NF‐κB signaling pathway
by: Li Yin, et al.
Published: (2023-04-01)

Single cell analysis and bioinformatics reveal pyroptosis mechanisms in hepatocellular carcinoma
by: Wei Luo, et al.
Published: (2025-06-01)

T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing
by: Xiong Y, et al.
Published: (2024-11-01)

Melatonin as a treatment for atherosclerosis: focus on programmed cell death, inflammation and oxidative stress
by: Reza Asemi, et al.
Published: (2025-04-01)

The double-edged role and therapeutic potential of TREM2 in atherosclerosis
by: Botao Zhu, et al.
Published: (2024-11-01)

Metformin Inhibited GSDME to Suppress M2 Macrophage Pyroptosis and Maintain M2 Phenotype to Mitigate Cisplatin-Induced Intestinal Inflammation
by: Ke Jiang, et al.
Published: (2024-11-01)

Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis
by: Qimeng Liu, et al.
Published: (2024-12-01)

Regulatory T cells and macrophages in atherosclerosis: from mechanisms to clinical significance
by: Xin Ouyang, et al.
Published: (2024-11-01)

Pyroptosis and its therapeutic potential
by: I. A. Odintsova, et al.
Published: (2024-07-01)

ELABELA Ameliorates Atherosclerosis Through Restoring the M1/M2 Macrophage Balance in ApoE−/− Mice
by: Le Tang, et al.
Published: (2025-07-01)

Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses
by: Zhuqi Huang, et al.
Published: (2023-03-01)

Proline/serine-rich coiled-coil protein 1 alleviates pyroptosis in murine bone marrow-derived macrophages
by: Wu Qiao, et al.
Published: (2025-02-01)

Advancing Roles and Therapeutic Potentials of Pyroptosis in Host Immune Defenses against Tuberculosis
by: Jiayi Yang, et al.
Published: (2024-10-01)

Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: Molecular mechanisms and targeted therapies
by: Pinglian Yang, et al.
Published: (2025-02-01)

CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation
by: Donghua Cai, et al.
Published: (2024-12-01)

A bibliometric analysis of macrophage-associated immune regulation in atherosclerosis: advances in the mechanisms of pathogenesis
by: Meiling Jiang, et al.
Published: (2025-06-01)

Therapeutic approaches for liver fibrosis/cirrhosis by targeting pyroptosis
by: Qiao Guanen, et al.
Published: (2025-07-01)

TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway
by: Xia L, et al.
Published: (2025-07-01)

Golden Tandem of Photothermal Ablation and Simultaneous Anti-Inflammation in One Nanoparticle for Activated Macrophage-Targeted Atherosclerosis Treatment
by: Lu Y, et al.
Published: (2025-02-01)

Kukoamine B regulates pyroptosis mediated by NLRP3/Caspase-1/GSDMD pathway to alleviate lipopolysaccharide-induced macrophage inflammation
by: NING Pu, et al.
Published: (2024-07-01)

LncRNA29RIK in macrophages promotes LPS-mediated sensitivity to obesity
by: Rong Wang, et al.
Published: (2025-04-01)

Foamy macrophages in atherosclerosis: unraveling the balance between pro- and anti-inflammatory roles in disease progression
by: Adil Ijaz, et al.
Published: (2025-05-01)

Regulation of pyroptosis by natural products in ulcerative colitis: mechanisms and therapeutic potential
by: Xiaobei Lu, et al.
Published: (2025-04-01)

Polysaccharide of Atractylodes macrocephala Koidz alleviate LPS-induced inflammatory liver injury by reducing pyroptosis of macrophage via regulating LncRNA GAS5/miR-223-3p/NLRP3 axis
by: Xiaoxiao Chen, et al.
Published: (2025-07-01)