A literature review of the network pharmacological mechanism of Sinisan of "different diseases and common treatment"
Objective To explore the pharmacological mechanism of Sinisan when using the same treatment to treat different diseases such as liver cancer, chronic hepatitis, fatty liver and Hashimoto's thy-roiditis, based on the published network pharmacology research.Methods The network pharmacology resear...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of New Medicine
2023-04-01
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| Series: | Yixue xinzhi zazhi |
| Subjects: | |
| Online Access: | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2304/Ddo7AcLeQ2gRsqm2TnSPZ3YigbqmV5NG58RxnzNS.pdf |
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| Summary: | Objective To explore the pharmacological mechanism of Sinisan when using the same treatment to treat different diseases such as liver cancer, chronic hepatitis, fatty liver and Hashimoto's thy-roiditis, based on the published network pharmacology research.Methods The network pharmacology research for Sinisan was retrieved and Sinisan’s active ingredients, targets and pathways corresponding to various diseases were extracted. A Microsoft Excel table was used to draw the Chinese medicine-disease component table, target-disease table, pathway-disease table and carry out descriptive analysis.Results A total of 20 studies on Sinisan's network pharmacology were included. There were 244 active ingredients corresponding to 14 diseases in 4 Chinese herbal medicines. The top 10 active ingredients were kaempferol, isorhamnetin, quercetin, paeoniflorin, formononetin, naringenin, isoflavone, shiitake mushroom, flavo-noids, and solanine. There were 243 corresponding targets and 395 pathways, among which VEGFA, IL-6, EGFR, CCND1, CASP3, STAT3, PPARG, ICAM1, FOS, CYP3A4 and other key targets played a role by reg-ulating important pathways such as the TNF signaling pathway, Tolllike receptor signaling pathway, PI3K-Akt signaling pathway, HIF-1 signaling pathway and membrane rafts pathway.Conclusion The research results show that Sinisan is efficacious for 14 diseases through multiple components, multiple tar-gets and multiple pathways. This study provides new clues for further exploring the mechanism of Sinisan's "Treating Different Diseases with the Same Treatment". |
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| ISSN: | 1004-5511 |