Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota
Background. Recently, the importance of the gut microbiota in the pathogenesis of several disorders has gained clinical interests. Among exogenous factors affecting gut microbiome, diet appears to have the largest effect. Fatty acids, especially omega-3 polyunsaturated, ameliorate a range of several...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/3089303 |
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| author | Blanca S. Noriega Marcos A. Sanchez-Gonzalez Daria Salyakina Jonathan Coffman |
| author_facet | Blanca S. Noriega Marcos A. Sanchez-Gonzalez Daria Salyakina Jonathan Coffman |
| author_sort | Blanca S. Noriega |
| collection | DOAJ |
| description | Background. Recently, the importance of the gut microbiota in the pathogenesis of several disorders has gained clinical interests. Among exogenous factors affecting gut microbiome, diet appears to have the largest effect. Fatty acids, especially omega-3 polyunsaturated, ameliorate a range of several diseases, including cardiometabolic and inflammatory and cancer. Fatty acids associated beneficial effects may be mediated, to an important extent, through changes in gut microbiota composition. We sought to understand the changes of the gut microbiota in response to an omega-3 rich diet. Case Presentation. This case study investigated changes of gut microbiota with an omega-3 rich diet. Fecal samples were collected from a 45-year-old male who consumed 600 mg of omega-3 daily for 14 days. After the intervention, species diversity was decreased, but several butyrate-producing bacteria increased. There was an important decrease in Faecalibacterium prausnitzii and Akkermansia spp. Gut microbiota changes were reverted after the 14-day washout. Conclusion. Some of the health-related benefits of omega-3 may be due, in part, to increases in butyrate-producing bacteria. These findings may shed light on the mechanisms explaining the effects of omega-3 in several chronic diseases and may also serve as an existing foundation for tailoring personalized medical treatments. |
| format | Article |
| id | doaj-art-3de1d44afe3f48f3895211966cf3046c |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-3de1d44afe3f48f3895211966cf3046c2025-02-03T01:29:16ZengWileyCase Reports in Medicine1687-96271687-96352016-01-01201610.1155/2016/30893033089303Understanding the Impact of Omega-3 Rich Diet on the Gut MicrobiotaBlanca S. Noriega0Marcos A. Sanchez-Gonzalez1Daria Salyakina2Jonathan Coffman3Division of Clinical & Translational Research, Larkin Community Hospital, South Miami, FL 33143, USADivision of Clinical & Translational Research, Larkin Community Hospital, South Miami, FL 33143, USAComputational Biology and Bioinformatics, University of Miami, Coral Gables, FL, USADepartment of Infectious Disease and Response, Saba University School of Medicine, Saba, Dutch Caribbean, NetherlandsBackground. Recently, the importance of the gut microbiota in the pathogenesis of several disorders has gained clinical interests. Among exogenous factors affecting gut microbiome, diet appears to have the largest effect. Fatty acids, especially omega-3 polyunsaturated, ameliorate a range of several diseases, including cardiometabolic and inflammatory and cancer. Fatty acids associated beneficial effects may be mediated, to an important extent, through changes in gut microbiota composition. We sought to understand the changes of the gut microbiota in response to an omega-3 rich diet. Case Presentation. This case study investigated changes of gut microbiota with an omega-3 rich diet. Fecal samples were collected from a 45-year-old male who consumed 600 mg of omega-3 daily for 14 days. After the intervention, species diversity was decreased, but several butyrate-producing bacteria increased. There was an important decrease in Faecalibacterium prausnitzii and Akkermansia spp. Gut microbiota changes were reverted after the 14-day washout. Conclusion. Some of the health-related benefits of omega-3 may be due, in part, to increases in butyrate-producing bacteria. These findings may shed light on the mechanisms explaining the effects of omega-3 in several chronic diseases and may also serve as an existing foundation for tailoring personalized medical treatments.http://dx.doi.org/10.1155/2016/3089303 |
| spellingShingle | Blanca S. Noriega Marcos A. Sanchez-Gonzalez Daria Salyakina Jonathan Coffman Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota Case Reports in Medicine |
| title | Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota |
| title_full | Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota |
| title_fullStr | Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota |
| title_full_unstemmed | Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota |
| title_short | Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota |
| title_sort | understanding the impact of omega 3 rich diet on the gut microbiota |
| url | http://dx.doi.org/10.1155/2016/3089303 |
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