The Health‐Related Quality of Life Impact of the COVID‐19 Pandemic on People Living with Multiple Sclerosis and the General Population: A Comparative Study Utilizing the EQ‐5D‐5L with Psychosocial Bolt‐Ons
ABSTRACT Objectives Studies have shown that people living with multiple sclerosis (PwMS) were substantially impacted by the COVID‐19 pandemic. However, no study has compared the overall health‐related quality of life impact of the COVID‐19 pandemic on PwMS and the general population. Differences wou...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70210 |
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| author | Glen J. Henson Ingrid van derMei Bruce V. Taylor Suzi B. Claflin Andrew J. Palmer Gang Chen Julie A. Campbell |
| author_facet | Glen J. Henson Ingrid van derMei Bruce V. Taylor Suzi B. Claflin Andrew J. Palmer Gang Chen Julie A. Campbell |
| author_sort | Glen J. Henson |
| collection | DOAJ |
| description | ABSTRACT Objectives Studies have shown that people living with multiple sclerosis (PwMS) were substantially impacted by the COVID‐19 pandemic. However, no study has compared the overall health‐related quality of life impact of the COVID‐19 pandemic on PwMS and the general population. Differences would have implications for crises/pandemic management policies. This study aimed to compare the prevalence and health‐related quality of life impact of COVID‐19‐related adversity (such as deteriorations in mental or physical health) in PwMS and the general population. Methods Cross‐sectional data were obtained from the How Is Your Life Australian general population study (comprising subsamples with and without chronic disease) and the Australian MS Longitudinal Study from August to October 2020. Health‐related quality of life was measured using health state utilities (HSUs; represented on a 0 [death] to 1 [full health] scale) generated by the EQ‐5D‐5L‐Psychosocial. COVID‐19‐related adversity was measured via specialized survey items. Descriptive and multivariable regression analyses were conducted. Results A total of 1020 general population individuals and 1635 MS participants entered the study (mean age 52.4 and 58.4; female 52.4% and 80.2%, respectively). COVID‐19‐related adversity prevalence was higher among PwMS compared to the general population with and without chronic diseases (PR: 1.430 [CI: 1.153, 1.774] and PR: 1.90 [CI: 1.56, 2.32], respectively). However, the HSU impact of COVID‐19‐related adversity was not dependent on disease status (p > 0.20, test for interaction). Conclusion This study found that PwMS were more likely to experience COVID‐19‐related adversity compared to the general population, though the health‐related quality‐of‐life impact was similar. This demonstrates that PwMS require additional support during national and global crises. |
| format | Article |
| id | doaj-art-3ddfce22806a48a780923831805d6010 |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-3ddfce22806a48a780923831805d60102025-01-29T13:36:39ZengWileyBrain and Behavior2162-32792025-01-01151n/an/a10.1002/brb3.70210The Health‐Related Quality of Life Impact of the COVID‐19 Pandemic on People Living with Multiple Sclerosis and the General Population: A Comparative Study Utilizing the EQ‐5D‐5L with Psychosocial Bolt‐OnsGlen J. Henson0Ingrid van derMei1Bruce V. Taylor2Suzi B. Claflin3Andrew J. Palmer4Gang Chen5Julie A. Campbell6Menzies Institute for Medical Research University of Tasmania Hobart Tasmania AustraliaMenzies Institute for Medical Research University of Tasmania Hobart Tasmania AustraliaMenzies Institute for Medical Research University of Tasmania Hobart Tasmania AustraliaMenzies Institute for Medical Research University of Tasmania Hobart Tasmania AustraliaMenzies Institute for Medical Research University of Tasmania Hobart Tasmania AustraliaCentre for Health Economics Monash University Caulfield East Victoria AustraliaMenzies Institute for Medical Research University of Tasmania Hobart Tasmania AustraliaABSTRACT Objectives Studies have shown that people living with multiple sclerosis (PwMS) were substantially impacted by the COVID‐19 pandemic. However, no study has compared the overall health‐related quality of life impact of the COVID‐19 pandemic on PwMS and the general population. Differences would have implications for crises/pandemic management policies. This study aimed to compare the prevalence and health‐related quality of life impact of COVID‐19‐related adversity (such as deteriorations in mental or physical health) in PwMS and the general population. Methods Cross‐sectional data were obtained from the How Is Your Life Australian general population study (comprising subsamples with and without chronic disease) and the Australian MS Longitudinal Study from August to October 2020. Health‐related quality of life was measured using health state utilities (HSUs; represented on a 0 [death] to 1 [full health] scale) generated by the EQ‐5D‐5L‐Psychosocial. COVID‐19‐related adversity was measured via specialized survey items. Descriptive and multivariable regression analyses were conducted. Results A total of 1020 general population individuals and 1635 MS participants entered the study (mean age 52.4 and 58.4; female 52.4% and 80.2%, respectively). COVID‐19‐related adversity prevalence was higher among PwMS compared to the general population with and without chronic diseases (PR: 1.430 [CI: 1.153, 1.774] and PR: 1.90 [CI: 1.56, 2.32], respectively). However, the HSU impact of COVID‐19‐related adversity was not dependent on disease status (p > 0.20, test for interaction). Conclusion This study found that PwMS were more likely to experience COVID‐19‐related adversity compared to the general population, though the health‐related quality‐of‐life impact was similar. This demonstrates that PwMS require additional support during national and global crises.https://doi.org/10.1002/brb3.70210COVID‐19health state utilitymultiple sclerosisoutcome measurementquality of life |
| spellingShingle | Glen J. Henson Ingrid van derMei Bruce V. Taylor Suzi B. Claflin Andrew J. Palmer Gang Chen Julie A. Campbell The Health‐Related Quality of Life Impact of the COVID‐19 Pandemic on People Living with Multiple Sclerosis and the General Population: A Comparative Study Utilizing the EQ‐5D‐5L with Psychosocial Bolt‐Ons Brain and Behavior COVID‐19 health state utility multiple sclerosis outcome measurement quality of life |
| title | The Health‐Related Quality of Life Impact of the COVID‐19 Pandemic on People Living with Multiple Sclerosis and the General Population: A Comparative Study Utilizing the EQ‐5D‐5L with Psychosocial Bolt‐Ons |
| title_full | The Health‐Related Quality of Life Impact of the COVID‐19 Pandemic on People Living with Multiple Sclerosis and the General Population: A Comparative Study Utilizing the EQ‐5D‐5L with Psychosocial Bolt‐Ons |
| title_fullStr | The Health‐Related Quality of Life Impact of the COVID‐19 Pandemic on People Living with Multiple Sclerosis and the General Population: A Comparative Study Utilizing the EQ‐5D‐5L with Psychosocial Bolt‐Ons |
| title_full_unstemmed | The Health‐Related Quality of Life Impact of the COVID‐19 Pandemic on People Living with Multiple Sclerosis and the General Population: A Comparative Study Utilizing the EQ‐5D‐5L with Psychosocial Bolt‐Ons |
| title_short | The Health‐Related Quality of Life Impact of the COVID‐19 Pandemic on People Living with Multiple Sclerosis and the General Population: A Comparative Study Utilizing the EQ‐5D‐5L with Psychosocial Bolt‐Ons |
| title_sort | health related quality of life impact of the covid 19 pandemic on people living with multiple sclerosis and the general population a comparative study utilizing the eq 5d 5l with psychosocial bolt ons |
| topic | COVID‐19 health state utility multiple sclerosis outcome measurement quality of life |
| url | https://doi.org/10.1002/brb3.70210 |
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