Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone)
Background: Bone health begins with maternal health and nutrition, which influences skeletal mass and bone mineral density (BMD) already in utero. Maximization of bone mass during skeletal growth has become the goal of primary prevention of osteopenia and osteoporosis. The amount of bone gained duri...
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Elsevier
2025-09-01
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| Series: | Global Pediatrics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667009725000193 |
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| author | Serafina Perrone Malgorzata Wasniewska Maria-Elisabeth Street Virginia Beretta Elena Scarpa Chiara Petrolini Andrea Dall’Asta Domenico Corica Tommaso Aversa Giorgia Pepe Letteria Morabito Federica Grassi Anna-Mariia Shulhai Valentina Bianco Anna Maria Papini Maria Cristina Albertini Silvia Carloni Giuseppe Maglietta Matteo Puntoni Caterina Caminiti Francesco Conversano Tullio Ghi |
| author_facet | Serafina Perrone Malgorzata Wasniewska Maria-Elisabeth Street Virginia Beretta Elena Scarpa Chiara Petrolini Andrea Dall’Asta Domenico Corica Tommaso Aversa Giorgia Pepe Letteria Morabito Federica Grassi Anna-Mariia Shulhai Valentina Bianco Anna Maria Papini Maria Cristina Albertini Silvia Carloni Giuseppe Maglietta Matteo Puntoni Caterina Caminiti Francesco Conversano Tullio Ghi |
| author_sort | Serafina Perrone |
| collection | DOAJ |
| description | Background: Bone health begins with maternal health and nutrition, which influences skeletal mass and bone mineral density (BMD) already in utero. Maximization of bone mass during skeletal growth has become the goal of primary prevention of osteopenia and osteoporosis. The amount of bone gained during growth and its subsequent rate of loss are closely linked to the final skeletal mass in adulthood. Radiofrequency Echographic Multi Spectrometry (REMS) technology has proven to be useful in the assessment of BMD in pregnant women. However, the feasibility of REMS for the assessment of bone status in newborns remains unknown. This multicenter longitudinal study aims at using REMS to evaluate skeletal status in fetuses, newborns and children until 12 months of age. Methods: Two hundred mother-newborn dyads, with infants born at term of gestation, will be consecutively recruited during the prenatal period and followed up until 12 months of life. BMD will be assessed with REMS technology in mothers, fetuses, newborns and infants at 1, 3 6 and 12 months of life. In all enrolled patients, blood will be collected at specific time points and oxidative stress biomarkers, specific microRNAs, and several bone metabolites will be measured in blood, whereas endocrine disruptors will be measured in urine. Discussion: This study is designed to provide robust data on the best method to identify and evaluate bone status starting from intrauterine life. The associations among BMD, maternal nutrition, early exposure to endocrine disruptors, and other investigated molecules will also be investigated in relationship with subsequent body composition and bone health. Trial registration: The protocol was retrospectively registered on ClinicalTrials.gov on December 3rd, 2024, with the ID number NCT06750523. |
| format | Article |
| id | doaj-art-3ddb266db81c4670a5749e73fbb41881 |
| institution | Kabale University |
| issn | 2667-0097 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Global Pediatrics |
| spelling | doaj-art-3ddb266db81c4670a5749e73fbb418812025-08-20T03:55:17ZengElsevierGlobal Pediatrics2667-00972025-09-011310026110.1016/j.gpeds.2025.100261Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone)Serafina Perrone0Malgorzata Wasniewska1Maria-Elisabeth Street2Virginia Beretta3Elena Scarpa4Chiara Petrolini5Andrea Dall’Asta6Domenico Corica7Tommaso Aversa8Giorgia Pepe9Letteria Morabito10Federica Grassi11Anna-Mariia Shulhai12Valentina Bianco13Anna Maria Papini14Maria Cristina Albertini15Silvia Carloni16Giuseppe Maglietta17Matteo Puntoni18Caterina Caminiti19Francesco Conversano20Tullio Ghi21Neonatology Unit, Department of Medicine and Surgery, University of Parma, Pietro Barilla Children’s Hospital, Parma 43121, Italy; Corresponding author.Department of Human Pathology of Adulthood and Childhood, Unit of Pediatrics, University of Messina, Messina 98124, ItalyPaediatric Clinic, University Hospital of Parma, University of Parma, Parma 43121, ItalyNeonatology Unit, Department of Medicine and Surgery, University of Parma, Pietro Barilla Children’s Hospital, Parma 43121, ItalyNeonatology Unit, Department of Medicine and Surgery, University of Parma, Pietro Barilla Children’s Hospital, Parma 43121, ItalyNeonatology Unit, Department of Medicine and Surgery, University of Parma, Pietro Barilla Children’s Hospital, Parma 43121, ItalyDepartment of Surgical Sciences, Obstetrics and Gynecology Unit, University of Parma, Parma, ItalyDepartment of Human Pathology of Adulthood and Childhood, Unit of Pediatrics, University of Messina, Messina 98124, ItalyDepartment of Human Pathology of Adulthood and Childhood, Unit of Pediatrics, University of Messina, Messina 98124, ItalyDepartment of Human Pathology of Adulthood and Childhood, Unit of Pediatrics, University of Messina, Messina 98124, ItalyDepartment of Human Pathology of Adulthood and Childhood, Unit of Pediatrics, University of Messina, Messina 98124, ItalyNeonatology Unit, Department of Medicine and Surgery, University of Parma, Pietro Barilla Children’s Hospital, Parma 43121, ItalyPaediatric Clinic, University Hospital of Parma, University of Parma, Parma 43121, ItalyPaediatric Clinic, University Hospital of Parma, University of Parma, Parma 43121, ItalyDepartment of Chemistry ''Ugo Schiff'', University of Florence, Via della Lastruccia 13, Sesto Fiorentino 50019, ItalyDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Via Aurelio Saffi 2, Urbino 61029, ItalyDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Via Aurelio Saffi 2, Urbino 61029, ItalyResearch an Innovation Unit, University Hospital of Parma, via Gramsci 14, Parma 43126, ItalyResearch an Innovation Unit, University Hospital of Parma, via Gramsci 14, Parma 43126, ItalyResearch an Innovation Unit, University Hospital of Parma, via Gramsci 14, Parma 43126, ItalyNational Research Council of Italy - Institute of Clinical Physiology, Lecce, ItalyDepartment of Surgical Sciences, Obstetrics and Gynecology Unit, University of Parma, Parma, ItalyBackground: Bone health begins with maternal health and nutrition, which influences skeletal mass and bone mineral density (BMD) already in utero. Maximization of bone mass during skeletal growth has become the goal of primary prevention of osteopenia and osteoporosis. The amount of bone gained during growth and its subsequent rate of loss are closely linked to the final skeletal mass in adulthood. Radiofrequency Echographic Multi Spectrometry (REMS) technology has proven to be useful in the assessment of BMD in pregnant women. However, the feasibility of REMS for the assessment of bone status in newborns remains unknown. This multicenter longitudinal study aims at using REMS to evaluate skeletal status in fetuses, newborns and children until 12 months of age. Methods: Two hundred mother-newborn dyads, with infants born at term of gestation, will be consecutively recruited during the prenatal period and followed up until 12 months of life. BMD will be assessed with REMS technology in mothers, fetuses, newborns and infants at 1, 3 6 and 12 months of life. In all enrolled patients, blood will be collected at specific time points and oxidative stress biomarkers, specific microRNAs, and several bone metabolites will be measured in blood, whereas endocrine disruptors will be measured in urine. Discussion: This study is designed to provide robust data on the best method to identify and evaluate bone status starting from intrauterine life. The associations among BMD, maternal nutrition, early exposure to endocrine disruptors, and other investigated molecules will also be investigated in relationship with subsequent body composition and bone health. Trial registration: The protocol was retrospectively registered on ClinicalTrials.gov on December 3rd, 2024, with the ID number NCT06750523.http://www.sciencedirect.com/science/article/pii/S2667009725000193Bone mineral density (BMD)Radiofrequency echographic multi spectrometry (REMS)Newborn infantsOsteoporosis preventionSkeletal growthEndorcrine disruptors |
| spellingShingle | Serafina Perrone Malgorzata Wasniewska Maria-Elisabeth Street Virginia Beretta Elena Scarpa Chiara Petrolini Andrea Dall’Asta Domenico Corica Tommaso Aversa Giorgia Pepe Letteria Morabito Federica Grassi Anna-Mariia Shulhai Valentina Bianco Anna Maria Papini Maria Cristina Albertini Silvia Carloni Giuseppe Maglietta Matteo Puntoni Caterina Caminiti Francesco Conversano Tullio Ghi Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone) Global Pediatrics Bone mineral density (BMD) Radiofrequency echographic multi spectrometry (REMS) Newborn infants Osteoporosis prevention Skeletal growth Endorcrine disruptors |
| title | Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone) |
| title_full | Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone) |
| title_fullStr | Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone) |
| title_full_unstemmed | Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone) |
| title_short | Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone) |
| title_sort | radiofrequency echographic multi spectrometry for early bone health the rems bone study protocol trial acronym rems bone |
| topic | Bone mineral density (BMD) Radiofrequency echographic multi spectrometry (REMS) Newborn infants Osteoporosis prevention Skeletal growth Endorcrine disruptors |
| url | http://www.sciencedirect.com/science/article/pii/S2667009725000193 |
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